2018
DOI: 10.1159/000485734
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Old and New Gut Hormone, Gastrin and Acid Suppressive Therapy

Abstract: Gastrin acts physiologically as a gut hormone to stimulate acid secretion after meal and as a cell-growth factor of oxyntic mucosa. Increase in serum gastrin level happens under various conditions including Zollinger-Ellison syndrome, antral G cell hyperplasia, autoimmune gastritis, atrophic gastritis, renal failure, vagotomy, Helicobacter pylori infection and acid suppressive therapy. As acid suppressive therapy causes hypergastrinemia, the association between acid suppressive therapy and gastric neuroendocri… Show more

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Cited by 16 publications
(16 citation statements)
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“…Recently, several reports have demonstrated the development of gastric hyperplastic polyps as well as fundic gland polyps in patients with long-term PPI use [5]. The polyps are suspected to be associated to hypergastrinemia induced by the prolonged use of PPI [3, 12, 13]. In our case, HP infection was negative, and the endoscopy found no hypergastrinemia-related gastric mucosa atrophy (776 pg/dL).…”
Section: Discussion/conclusionmentioning
confidence: 51%
“…Recently, several reports have demonstrated the development of gastric hyperplastic polyps as well as fundic gland polyps in patients with long-term PPI use [5]. The polyps are suspected to be associated to hypergastrinemia induced by the prolonged use of PPI [3, 12, 13]. In our case, HP infection was negative, and the endoscopy found no hypergastrinemia-related gastric mucosa atrophy (776 pg/dL).…”
Section: Discussion/conclusionmentioning
confidence: 51%
“…Chronic hypergastrinemia, which has both long-fascinated investigators/clinicians, as well as being a constant source of contention and puzzlement, has recently been receiving increased attention [10,37,38,39,40,41]. It has long fascinated investigators/clinicians because of its multiple causes including diseases such as pancreatic neuroendocrine tumors (panNET) and other neuroendocrine tumors (NETs) causing fasting gastrin levels >100-fold increased, associated with such florid acid hypersecretion that if untreated (i.e., ZES), it frequently leads to a fatal outcome [24,28,29,42].…”
Section: Chronic Hypergastrinemia: Generalmentioning
confidence: 99%
“…Since the development of sensitive gastrin radio-immunoassays in the 1960s, it has become clear that chronic hypergastrinemia is not an infrequent finding and that it has both physiologic and pathophysiological causes [10,37,38,39,40,41]. The physiological causes can be a response to anything that results in prolonged hypo/achlorhydria, which can include processes as varied as the chronic use of potent acid suppressive drugs, gastric infections such as Helicobacter pylori, and postsurgical procedures such as vagotomy or other gastric acid-reducing surgeries [10,37,38,39,40,41].…”
Section: Chronic Hypergastrinemia: Generalmentioning
confidence: 99%
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“…Gastrin secretion is inhibited by increased acidity of the stomach (pH 3 or below), low-level gastric distension and somatostatin [8]. Gastrin works on the parietal cells to stimulate acid secretion and has a trophic effect on the oxyntic mucosa [9]. The precursor of gastrin is progastrin which is synthesized and stored in the secretory granules of antral G cells.…”
Section: Gastrinmentioning
confidence: 99%