Old habits die hard: retrospective analysis of outcomes with use of corticosteroids and antibiotics before embryo transfer

Kaye, Leah; Bartels, Chantal; Bartolucci, Alison; Engmann, Lawrence; Nulsen, John; Benadiva, Claudio

doi:10.1016/j.fertnstert.2017.04.003

Cited by 20 publications

(10 citation statements)

References 11 publications

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“…A similar conclusion was obtained using 16S rRNA gene sequencing of endometrial biopsy samples taken prior to IVF cycles (Moreno et al, 2016). Despite this, the ability to modify FGT microbiota to improve IVF outcomes is less clear, as there are conflicting data as to whether antibiotic treatment during IVF improves pregnancy rates (Kaye et al, 2017). Nonetheless, Lactobacillus-dominant communities appear beneficial for a number of obstetric outcomes.…”

Section: Obstetric Outcomesmentioning

confidence: 52%

“…Of note, although some BV-associated species demonstrate resistance to common antibiotics like metronidazole in vitro (De Backer et al, 2006), vaginal colonization is dramatically reduced with antibiotic administration in a clinical setting (Fredricks et al, 2009). Although effective in decreasing colonization by pathogenic species, antibiotic treatment has not successfully altered clinical outcomes associated with non-Lactobacillus-dominant vaginal microbiota such as PTB (reviewed in Thinkhamrop et al, 2015) or pregnancy rates with IVF treatment (reviewed in Kaye et al, 2017).…”

Section: Modulation Of the Female Genital Tract Microenvironment Bymentioning

confidence: 99%

See 1 more Smart Citation

Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity

Anahtar

Gootenberg

Mitchell

et al. 2018

Cell Host & Microbe

207

172

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Cervicovaginal microbiota play a critical role in women's health and reproductive outcomes. Despite being one of the simplest commensal bacterial communities in the human body, we are only beginning to appreciate its complex dynamic nature and important role in host immune modulation. In this review, we discuss the "optimal" cervicovaginal bacterial community composition, the impact of microbiota on gynecologic and obstetric outcomes, and the hurdles to developing a deeper mechanistic understanding of the function of the cervicovaginal microbiome. We then describe efforts to durably alter microbial composition in this compartment by promotion of Lactobacillus colonization with probiotics, modulation of vaginal pH, hormonal administration, and the eradication of pathogenic bacteria with antibiotics. Finally, we draw on lessons learned from the deeply investigated gut microbiome to suggest future avenues of research into host-pathogen interactions in the female genital tract.

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Section: Obstetric Outcomesmentioning

confidence: 52%

Section: Modulation Of the Female Genital Tract Microenvironment Bymentioning

confidence: 99%

Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity

Anahtar

Gootenberg

Mitchell

et al. 2018

Cell Host & Microbe

207

172

View full text Add to dashboard Cite

show abstract

“…Oocyte retrieval was performed transvaginally 36 hours later. Even if the benefits of the prophylaxis with antibiotics remains debated (Bhandari et al, 2015;Kaye et al, 2017), the policy of our unit was to systematically administer Ceftriaxone 2 g intravenously (Clarithromycin 500 mg for women who were allergic) at the time of the retrieval.…”

Section: Methodsmentioning

confidence: 99%

Oocyte retrieval difficulties in women with ovarian endometriomas

Benaglia

Busnelli

Biancardi

et al. 2018

Reproductive BioMedicine Online

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“…In a national study on birth anomalies, there was no significant association between exposure to tetracyclines during the first months of pregnancy (46 mothers) and the presence of orofacial clefts [adjusted odds ratio (AOR) of 2.0, 95% CI 0.6–6.7] [46]. Additionally, the recommendation for the use of doxycycline in combination with steroids in in vitro fecundation as per-implantation prophylaxis to protect the embryo is favoured by its very weak toxicity against embryo [47, 48]. The overall evidence suggests that the risk of congenital malformations in infants whose mother received doxycycline is very low [31, 41, 43–46, 49–51].…”

Section: Potential Teratogenicity Of Doxycyclinementioning

confidence: 99%

Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

Gaillard¹,

Madamet²,

Pradines³

2018

Malar J

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According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child. The administration of intermittent preventive treatment (IPTp) with sulfadoxine–pyrimethamine (SP) at each antenatal care visit as early as 13 weeks of gestation until the time of delivery is a strategy that is currently recommended by WHO for the prevention of malaria in pregnancy. However, the emergence and the spread of the resistance to SP in Africa raise the question of the short-term effectiveness of the strategy. Dihydroartemisinin–piperaquine 120 mg/960 mg once a day for 3 consecutive days administered at least three times during the pregnancy might be an option for IPTp. The combination of 200 mg of doxycycline once a day for 3 consecutive days seems to be a good option to retard the emergence and the spread of resistance to artemisinin-based combination therapy (ACT) in Africa and improve the effectiveness of ACT in term of preterm births, neonatal morbidity and mortality. Contrary to preconceived ideas, scientific and medical data suggest that the risk of congenital malformations in the fetus or of tooth staining in infants whose mothers take doxycycline and hepatotoxicity during pregnancy is very low or non-existent. Additionally, the use of doxycycline during the first and second trimesters leads to an increase in gestational age at delivery, a decrease in the number of preterm births and a reduction in neonatal morbidity and mortality due to the beneficial antimicrobial activity of doxycycline against other infections during pregnancy. Furthermore, doxycycline has anti-malarial properties and is already recommended as prophylaxis for travellers and for treatment of falciparum malaria in combination with other anti-malarial drugs.

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Old habits die hard: retrospective analysis of outcomes with use of corticosteroids and antibiotics before embryo transfer

Abstract: No statistically significant difference in overall IVF outcomes was noted after the discontinuation of routine peri-implantation corticosteroids and antibiotics. The use of these medications varies across the country and may be a result of habit rather than evidence-based medicine.

Cited by 20 publications

References 11 publications

Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity

Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity

Oocyte retrieval difficulties in women with ovarian endometriomas

Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

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