The Indus River has been progressively transformed in the last decades into a tightly-regulated system of dams and channels, to produce food and energy for the rapidly growing population of Pakistan.Nevertheless, Indus River sands as far as the delta largely retain their distinct feldspar-and amphibole-rich composition, which is unique with respect to all other major rivers draining the Alpine-Himalayan belt except for the Brahmaputra. Both the Indus and Brahmaputra Rivers flow for half of their course along the India-Asia suture zone, and receive major contributions from both Asian active-margin batholiths and upper-amphibolite-facies domes rapidly exhumed at the Western and Eastern Himalayan syntaxes. Detailed information on bulk petrography and heavy minerals of modern Indus sands not only represents an effective independent method to constrain denudation rates obtained from temperature-time histories of exposed bedrock, but also provides an actualistic reference for collision-orogen provenance, andgives us a key to interpreting provenance and paleodrainage changes recorded by clastic wedges deposited in the Himalayan foreland basin and Arabian Sea during the Cenozoic.3