Old Rats Are More Susceptible to Induction of Benign Prostatic Hyperplasia (BPH) at Comparative to Young Mature

Abstract

Aims: The aim of the experiments was to find out the factors on which age-related sensitivity to the occurrence of BPH depends. Methods: 45 male Wistar rats aged 3 and 24 months were used. In each age group there were intact rats and animals with induced BPH (by surgical castration + testosterone injections, 25 mg/kg x 7). On the 36th day of the experiment, blood was taken from rats to determine serum testosterone, cholesterol, triglycerides and glucose; then the animals were autopsied, their prostates were weighed, and their morphology was studied. Results: Young mature intact rats had much higher testosterone levels (6.2±0.93 nmol/l) than old intact (3.8±0.55 nmol/l), while the ratio of prostate weight was inverse. The weight of the prostate and prostatic index in old rats with induced BPH was significantly higher not only in comparison with the old intact rats but also with young animals after BPH induction. Morphologically, the inflammatory foci were determined not only in the prostates of old rats, which induced BPH, but also in intact animals. Besides in old intact rats, the foci of prostate hyperplasia were often noted. Conclusions: Our experimental model indicates the important role of non-bacterial prostatitis in the pathogenesis of BPH. No metabolic disorders in BPH induction were revealed. The sensitivity of the prostate of old rats to BPH development is increasing despite the low concentrations of testosterone in the body. Age sensitivity to BPH is probably determined by a higher expression of androgen receptors in old animals.

In Vivo and in Silico Assessment of Ameliorative Effects of Xylopia aethiopica on Testosterone Propionate-Induced Benign Prostatic Hyperplasia

“…XAE-treated rats showed a reduction in epithelial hyperplasia with a decrease in epithelial thickness. 42 In this study, the observed reduction in prostate weight was similar to the ones shown by finasteride, a 5-α-reductase inhibitor that is suggestive of the inhibitory activity of XAE against the development of BPH ( Table 2 ).…”

Frequency of Prostatic Adenocarcinoma in Transurethral Resection of Prostatectomy Done for Benign prostatic Enlargement and Correlation with Serum Level of PSA

“…To promote early diagnosis and treatment, national-level research and health policies are necessary. 34 CONCLUSION PSA levels were also raised in a case of prostatitis and two cases of BPH. We conclude that PSA levels although suggestive are not entirely specific for prostatic adenocarcinoma.…”

“…Advanced-stage prostatic adenocarcinoma is diagnosed more often and at an earlier age, according to studies conducted in Pakistan. 34,35 An annual rise (p-value=0.053) has been observed in the number of cases of prostatic diseases diagnosed. To promote early diagnosis and treatment, national-level research and health policies are necessary.…”

Antioxidant mitoquinone suppresses benign prostatic hyperplasia by regulating the AR–NLRP3 pathway

“…The testosterone-induced BPH rats model has shown a significant increase in urinary frequency and a decrease in mean voided volume, which is very similar to the clinical symptoms experienced by BPH patients. Although a recent study has reported that old rats are more susceptible to developing BPH in comparison to young rats, it has also been found that young rats treated with testosterone exhibit a significant increase in prostate weight and prostatic index [ 50 ]. However, additional experiments using mature rats are also needed for the future clinical use of MitoQ.…”