Older Age Is an Adverse Prognostic Factor in Stage I, Favorable Histology Wilms’ Tumor Treated With Vincristine Monochemotherapy: A Study by the United Kingdom Children’s Cancer Study Group, Wilm’s Tumor Working Group

Pritchard‐Jones, Kathy; Kelsey, Anna; Vujanić, Gordan; Imeson, John; Hutton, C. F.; Mitchell, Chris

doi:10.1200/jco.2003.01.062

Cited by 102 publications

(63 citation statements)

References 18 publications

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“…Cooperative studies have shown that increasing age is associated with an increased risk of recurrence of nonmetastatic WT (6,7,(9)(10)(11). This is only partly explained by the fact that the occurrence of anaplasia increases with age (12); even in patients with favorable histology, older age seems to be associated with less favorable outcome.…”

Section: Generalmentioning

confidence: 99%

“…Anaplasia is only very rarely seen in WT diagnosed during the first year of life and is also rare in the second year of life (12). Nevertheless, even in the group of patients with favorable histology, older age seems to be correlated with a higher risk of relapse and death, although prognostic factors such as stage or histology seem to be more powerful (7). Other suggested reasons for the adverse survival rates in older children are delay in diagnosis, advanced tumor stage at presentation, and intrinsically different biological behaviors (7).…”

Section: Age In Correlation With Other Prognostic Factorsmentioning

confidence: 99%

“…Over the last decade, age at diagnosis also was suggested to be an important risk factor for WT recurrence in COG, UK (United Kingdom), and SIOP studies (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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The Clinical Relevance of Age at Presentation in Nephroblastoma

et al. 2016

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Licence: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. AbstractThe most important prognostic factors for Wilms tumor (WT) patients seem to be stage, histological subtype, and 1p/16q loss of heterozygosity (LOH) in chemotherapy-naive WTs. 24Over the last decade, age at diagnosis also was suggested to be an important risk factor for WT recurrence in Children's Oncology Group (COG), United Kingdom (UK), and International Society of Pediatric Oncology (SIOP) studies. Several studies have analyzed age as a prognostic factor; these studies revealed age <2 years as a favorable prognostic factor, while age >4 years has been described as an adverse prognostic factor. In adults (>18 years of age), WT represents less than 1% of all diagnosed renal tumors; therefore, diagnosis of WT in adults is often unexpected and poorly recognized, thereby inducing treatment delay with subsequent adverse outcome. One explanation for the higher risk of recurrence with increasing patient age is the higher frequency of anaplasia at higher age. Other suggested reasons are delay in diagnosis, advanced tumor stage at presentation, and intrinsically different biological behaviors. Whether age is really an independent risk factor, and whether age is a stronger prognostic factor than stage, histology, and LOH 1p/16q, needs to be further explored. This may provide some insight into whether older patients need to be treated more intensively, as is already advised for adult WT patients.

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Section: Generalmentioning

confidence: 99%

Section: Age In Correlation With Other Prognostic Factorsmentioning

confidence: 99%

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The Clinical Relevance of Age at Presentation in Nephroblastoma

et al. 2016

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“…Cooperative group studies have shown that increasing patient age is associated with increased risk of recurrence in nonmetastatic Wilms' tumor [14][15][16][17]. A subgroup with an outstanding prognosis are patients less than 2 years of age with small (<550 g) stage I favorable histology tumors [18][19][20].…”

Section: Patient Agementioning

confidence: 99%

Current Therapy for Wilms’ Tumor

2005

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“…Also, in a study by Pritchard-Jones, it was shown that older children (> 4 years) are at increased risk of recurrence (p = 0.001) [9]. In that study, 242 patients with stage I tumors and favorable histopathology were studied.…”

Section: Discussionmentioning

confidence: 99%

Clinical Factors in Relapses of Wilms’ Tumor – Results for the Polish Pediatric Solid Tumors Study Group

Niedzielska

Bronowicki²,

Pietras

et al. 2014

Adv Clin Exp Med

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Of these 34 patients, 11 initially had CS I, seven were at CS II, four were at CS III, 11 were at CS IV and one had CS V. There were eight patients with second recurrences; of these, seven were in the INT risk group and one in the high histological risk group. There was no correlation between age (p = 0.256) or gender (p = 0.538) and the risk of tumor recurrence. In the study group, seven out of 10 patients with local recurrences are alive; as are 13 out of 22 patients with distant recurrences

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Older Age Is an Adverse Prognostic Factor in Stage I, Favorable Histology Wilms’ Tumor Treated With Vincristine Monochemotherapy: A Study by the United Kingdom Children’s Cancer Study Group, Wilm’s Tumor Working Group

Cited by 102 publications

References 18 publications

The Clinical Relevance of Age at Presentation in Nephroblastoma

The Clinical Relevance of Age at Presentation in Nephroblastoma

Current Therapy for Wilms’ Tumor

Clinical Factors in Relapses of Wilms’ Tumor – Results for the Polish Pediatric Solid Tumors Study Group

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