Older HIV-infected patients—an underestimated population in northern Greece: epidemiology, risk of disease progression and death

Metallidis, Symeon; Tsachouridou, Οlga; Skoura, Lemonia; Zebekakis, Pantelis; Chrysanthidis, Theofilos; Pilalas, Dimitrios; Bakaimi, Isidora; Kollaras, Panagiotis; Tsiara, Aikaterini; Γαλανός, Αντώνιος; Malisiovas, Nikolaos; Nikolaidis, Pavlos

doi:10.1016/j.ijid.2013.02.023

Cited by 19 publications

(36 citation statements)

References 50 publications

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“…Incidence of HIV infection might have been as high among older adults as it was among youths but the picture was unclear because they have been more or less neglected in HIV testing and prevention programmes 6 . Most of the current knowledge about the characteristics of HIV infection in older persons has come from the developed countries in North America 7,8 and Europe [9][10][11] . The pattern has also been described in China 12,13 and Taiwan…”

Section: Introductionmentioning

confidence: 99%

“…As expected, this poor health status at presentation predisposes older adults to faster disease progression, poor treatment success and higher mortality. Metallides et al also reported higher prevalence of cardiovascular and neurological conditions among older adults, though these are health conditions associated with old age 9 . Sub-Saharan Africa is lagging behind in terms of literature on the characteristics of HIV infection in older adults.…”

mentioning

confidence: 96%

“…Many of these studies suggested that older and younger adults differ in terms of epidemiological and clinical features of HIV infection, response to ART and post-diagnosis survival. Heterosexual contact was the most common HIV risk factor reported among older adults 9,12 . In addition, they have lower CD4 counts, higher prevalence of opportunistic infections, and more likely to be at an advanced stage of HIV/AIDS at first presentation 10,11,13 .…”

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confidence: 99%

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Demographic and epidemiological characteristics of HIV opportunistic infections among older adults in Nigeria

et al. 2017

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Background: In view of the maturing HIV epidemic in sub-Saharan Africa, better understanding of its epidemiology among older adults is necessary in order to design appropriate care and treatment programmes for them. Objectives: To describe the demographic and epidemiological characteristics of HIV opportunistic infections among newly enrolled patients aged 50 years and above in Ibadan, South-West Nigeria. Methods: Analysis of data extracted from electronic records of 17, 312 subjects enrolled for HIV/AIDS care and treatment between January 2006 and December 2014 at the ART clinic, University College Hospital, Ibadan. Results: Age of the patients ranged from 18 to 90 years with a mean of 36.4 years (SD= 10.3) with older adults constituting 12.0% (2075). Among older adults, about half (52.9%) were females. Majority (59.1%) were currently married while 25.9% were widowed. Prevalence of opportunistic infections was 46.6%. The commonest opportunistic infections (OIs) were: oral candidiasis (27.6%), chronic diarrhoea (23.5% and peripheral neuropathy (14.8%). Significant factors associated with opportunistic infections in older adults were: CD4 count less than 350 (OR=3.12, CI: 2.29-4.25) and hepatitis C virus co-infection (OR=2.17, CI: 1.14-4.13). Conclusion: There is need for prompt response to the peculiar challenges associated with the emerging shift in the epidemiology of HIV and associated infections in sub-Saharan Africa.

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Section: Introductionmentioning

confidence: 99%

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confidence: 96%

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confidence: 99%

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Demographic and epidemiological characteristics of HIV opportunistic infections among older adults in Nigeria

et al. 2017

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“…Among the 19 primary studies reporting data on HIV test uptake, six were performed in the EU/EEA [38][39][40][41][42][43],one in Australia [44] and the remainder in the USA [31,[45][46][47][48][49][50][51][52][53][54][55] (Web Annex Table 6). Generally, the findings pointed at a lower frequency of HIV test uptake among older adults as compared to younger age groups, even if the actual proportion of tested individuals varied greatly between studies.…”

Section: Patterns Of New Hiv Diagnosis and Hiv Test Uptakementioning

confidence: 99%

“…Generally, the findings pointed at a lower frequency of HIV test uptake among older adults as compared to younger age groups, even if the actual proportion of tested individuals varied greatly between studies. Two European [38,40] and several non-EU surveys [44,45,47,51,53,55] reported that 50% to less than 5% older adults, with majority around 25%, had tested for HIV. Three studies reported the level of testing among patients diagnosed with an indicator-condition [39,43,54] to be low generally and significantly lower in older adults than in the younger age groups.…”

Section: Patterns Of New Hiv Diagnosis and Hiv Test Uptakementioning

confidence: 99%

New HIV Diagnoses among Older Adults in the EU/EEA: Missed Opportunities and Barriers to Testing

Tavoschi¹,

Madeddu²,

Pharris³

2017

J AIDS Clin Res

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The rate of HIV diagnoses among older adults in the European Union/European Economic Area (EU/EEA) is increasing. We performed a literature review to investigate factors associated with HIV infection, diagnosis and testseeking behaviour among older adults in the EU/EEA.We defined older adults as ≥ 50 years. We searched Embase and PubMed to identify studies on socio-demographic and clinical characteristics associated with new HIV diagnosis and factors influencing provision and uptake of HIV testing among older adults in EU/EEA and other high-income countries using the concepts of HIV infection and disease; older adults, and; testing and attitude towards testing. We included original papers or systematic reviews published from 2000 onwards and reporting data on the following themes: Patterns of HIV test uptake and attitudes, barriers and enablers influencing offer and uptake of HIV testing.Published evidence indicated large proportion of late diagnoses and a low likelihood of HIV testing among older adults, although results varied widely between studies. HIV test uptake was a function of several factors related to patient and provider, including perception of one's risk. The active offer of an HIV test by the health care provider was the most significant factor positively associated with having a test. Scaling up HIV testing opportunities targeting older adults and the adult population at large is needed.

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Investigation of CCR5-Δ32 (rs333) genetic polymorphism frequency and its relationship with HIV-1 susceptibility and disease progression: A Moroccan case-control study

et al. 2019

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Older HIV-infected patients—an underestimated population in northern Greece: epidemiology, risk of disease progression and death

Cited by 19 publications

References 50 publications

Demographic and epidemiological characteristics of HIV opportunistic infections among older adults in Nigeria

Demographic and epidemiological characteristics of HIV opportunistic infections among older adults in Nigeria

New HIV Diagnoses among Older Adults in the EU/EEA: Missed Opportunities and Barriers to Testing

Investigation of CCR5-Δ32 (rs333) genetic polymorphism frequency and its relationship with HIV-1 susceptibility and disease progression: A Moroccan case-control study

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