Older Men and Women Efficiently Absorb Vitamin B-12 from Milk and Fortified Bread

Russell, Robert M.; Baik, Hyun Wook; Kehayias, Joseph J.

doi:10.1093/jn/131.2.291

Cited by 42 publications

(18 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, casein itself could be involved because fractions of this protein were identified as major components of the protein-binding capacity of vitamin B 12 in cows' milk (32) . Globally, these explanations are in accordance with the numerically greater, although not statistically significant, efficiency of absorption of dietary 58 Co-labelled cyanocobalamin when given in milk (65 %) rather than in water or bread (55 %) (33) . Nevertheless, it cannot be ruled out that the current lack of vitamin B 12 absorption after ingestion of meals supplemented with cyanocobalamin (C-S and E -S) was related to the fibre content of feedstuffs, which could interfere with the intestinal bioavailability of dietary cyanocobalamin as observed by Cullen & Oace (34) .…”

Section: Discussionsupporting

confidence: 73%

Bioavailability of vitamin B₁₂ in cows' milk

2011

View full text Add to dashboard Cite

The natural source of vitamin B 12 in human diets comes from animal products. For example, one glass (250 ml) of milk provides approximately 50 % of the RDA (2·4 mg/d). It was hypothesised that the provision of vitamin B 12 from milk is more efficiently absorbed than the synthetic form used in vitamin supplements. Pigs (n 10) were used as a model for intestinal absorption of vitamin B 12 in humans to compare the net fluxes of vitamin B 12 across the portal-drained viscera (PDV; an indicator of intestinal absorption) after ingestion of meals complemented with conventional and vitamin B 12 -enriched (via injections to cows) milk (raw, pasteurised or microfiltrated) or with equivalent amounts of cyanocobalamin, the synthetic form used in supplements or unsupplemented. Net flux of vitamin B 12 across PDV after the ingestion of milk was positive, though not influenced by milk enrichment (P. 0·3) or technological processes (P¼0·8) and was greater than after ingestion of equivalent amounts of cyanocobalamin (cyanocobalamin v. all milk, P# 0·003). In fact, net fluxes of this vitamin were not different from 0 after either cyanocobalamin or the meal devoid of vitamin B 12 (unsupplemented v. cyanocobalamin, P¼ 0·7). The cumulative PDV fluxes during the 24 h following ingestion of meals complemented with milk varied from 5·5 to 6·8 mg. These values correspond to an efficiency of intestinal absorption of vitamin B 12 from milk varying between 8 and 10 %. Therefore, vitamin B 12 , which is abundant in cows' milk, is also substantially more available than the most commonly used synthetic form of this vitamin.

show abstract

Section: Discussionsupporting

confidence: 73%

Bioavailability of vitamin B₁₂ in cows' milk

2011

View full text Add to dashboard Cite

show abstract

“…Absorption of crystalline vitamin B12 is usually not affected in subjects with food-bound malabsorption, and therefore most European countries recommend elderly people to consume a high proportion of their vitamin B12 intake as fortified foods and supplements [1]. In two studies investigating absorption from bread, squash or milk fortified with 0.25-0.5 µg vitamin B12, an absorption between 55 and 74% was observed [12,36]. …”

Section: Discussionmentioning

confidence: 99%

“…Currently, the bioavailability of vitamin B12 is generally assumed to be 40 or 50% for healthy adults with normal gastrointestinal functioning [2,4,5,6,7]. This assumption is based on the absorption of labeled vitamin B12 from a few food products, including mutton and chicken meat, rainbow trout, eggs or fortified foods [8,9,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Systematic Review on Daily Vitamin B12 Losses and Bioavailability for Deriving Recommendations on Vitamin B12 Intake with the Factorial Approach

et al. 2013

View full text Add to dashboard Cite

Aims: To systematically review the literature on daily losses and bioavailability of vitamin B12. These estimates could be used for deriving recommendations on vitamin B12 intake for adults and elderly. Methods: We identified publications on daily vitamin B12 losses (July 2011) and publications on the bioavailability of vitamin B12 from foods or diets (June 2010) in MEDLINE, EMBASE and the Cochrane Library. Results: A pooled analysis of five studies (52 subjects) showed that 0.13 ± 0.03% of the total body store is lost per day. Absorption of vitamin B12 ranged from 4.5 (dose of 38 µg from consumption of liver) to 83% (dose of 3.0 µg from consumption of mutton meat). Data from eight studies including 83 subjects suggested that the amount of vitamin B12 absorbed from food (A_i) increased with increasing doses of vitamin B12 (D_i) as described by the equation: ln(A_i) = 0.7694 * ln(D_i) - 0.9614. Conclusion: Daily vitamin B12 losses in apparently healthy adults and elderly probably range from 1.4 to 5.1 µg. Vitamin B12 intakes needed to compensate for these losses seem to range from 3.8 to 20.7 µg. More evidence is needed on the relationships between biochemical markers of vitamin B12 status, vitamin B12 body store and long-term health outcomes to evaluate whether current recommendations on vitamin B12 intake (1.4-3 µg) need to be changed.

show abstract

“…However, the exact dose at which this occurs remains currently unknown, in part due to the difficulty of assessing vitamin B 12 deficiency. Moreover, whereas oral administration of crystalline cyanocobalamin seems to be an effective treatment for food-cobalamin malabsorption, it remains unknown whether it is the same regarding vitamin B 12 from fortified food (Russell et al 2001).…”

Section: Prevention Of B Vitamin Deficiency During Ageingmentioning

confidence: 99%

Age-associated B vitamin deficiency as a determinant of chronic diseases

Brachet¹,

Chanson²,

Demigné³

et al. 2004

Nutr. Res. Rev.

View full text Add to dashboard Cite

The number of elderly individuals is growing rapidly worldwide and degenerative diseases constitute an increasing problem in terms of both public health and cost. Nutrition plays a role in the ageing process and there has been intensive research during the last decade on B vitaminrelated risk factors in vascular and neurological diseases and cancers. Data from epidemiological studies indicate that subclinical deficiency in most water-soluble B vitamins may occur gradually during ageing, possibly due to environmental, metabolic, genetic, nutritional and pathological determinants, as well as to lifestyle, gender and drug consumption. Older adults have distinct absorption, cell transport and metabolism characteristics that may alter B vitamin bioavailability. Case-control and longitudinal studies have shown that, concurrent with an insufficient status of certain B vitamins, hyperhomocysteinaemia and impaired methylation reactions may be some of the mechanisms involved before a degenerative pathology becomes evident. The question that arises is whether B vitamin inadequacies contribute to the development of degenerative diseases or result from ageing and disease. The present paper aims to give an overview of these issues at the epidemiological, clinical and molecular levels and to discuss possible strategies to prevent B vitamin deficiency during ageing.

show abstract

Older Men and Women Efficiently Absorb Vitamin B-12 from Milk and Fortified Bread

Cited by 42 publications

References 16 publications

Bioavailability of vitamin B₁₂ in cows' milk

Bioavailability of vitamin B₁₂ in cows' milk

Systematic Review on Daily Vitamin B12 Losses and Bioavailability for Deriving Recommendations on Vitamin B12 Intake with the Factorial Approach

Age-associated B vitamin deficiency as a determinant of chronic diseases

Contact Info

Product

Resources

About

Older Men and Women Efficiently Absorb Vitamin B-12 from Milk and Fortified Bread

Cited by 42 publications

References 16 publications

Bioavailability of vitamin B12 in cows' milk

Bioavailability of vitamin B12 in cows' milk

Systematic Review on Daily Vitamin B12 Losses and Bioavailability for Deriving Recommendations on Vitamin B12 Intake with the Factorial Approach

Age-associated B vitamin deficiency as a determinant of chronic diseases

Contact Info

Product

Resources

About

Bioavailability of vitamin B₁₂ in cows' milk

Bioavailability of vitamin B₁₂ in cows' milk