Older Patients Treated for Lung and Thoracic Cancers: Unplanned Hospitalizations and Overall Survival

Clinical Outcomes, Treatment Toxicity, and Health Care Utilization in Older Adults with Aggressive Non-Hodgkin Lymphoma

“…We also assessed factors associated with the rates of (a) grade 3-5 nonhematologic toxicity (yes vs. no) and (b) unplanned hospitalization within 6 months of treatment initiation (yes vs. no) given the clinical importance of these outcomes. We used multivariable logistic regression to examine the association between patient demographics and clinical factors and these binary outcomes of interest [18,19]. We first conducted univariate analyses to assess the association between patient demographic (age, sex, race, marital status) and clinical factors (ECOG performance status, comorbidity score; dichotomized to <2 versus ≥2 consistent with prior work) [11], advanced stage, hypoalbuminemia (defined as <3.5 g/dL consistent with prior work) [20], elevated LDH (≥250 U/L consistent with prior work) [21], diagnosis (DLBCL vs. all other histologies), treatment regimen (reduced-dose CHOP [mini-CHOP] with or without rituximab, CHOP with or without rituximab, EPOCH with or without rituximab, or other), and CNS prophylaxis (yes or no) with the binary outcomes of interest.…”