Older patients with IBD might have higher risk of Parkinson’s disease

Wan, Qianyi; Zhao, Rui; Wu, Xiaoting

doi:10.1136/gutjnl-2018-317103

Cited by 27 publications

(22 citation statements)

References 9 publications

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“…In a systematic review and meta-analysis, Wan et al (2018) found that IBD patients did not show increased risk of PD, however, a subgroup analysis showed a significant difference in the more aged patients (>60 years old). Zhu et al (2019) suggested that both CD and UC patients have an increased risk of PD compared to the control subjects.…”

Section: Relationship Between Gut Inflammation and Pdmentioning

confidence: 95%

“…Moreover, Cote et al (2015) found clear presence of M1 monocytes and increased IL-1βand IL-6 in the gut, while in the partial depletion of M1 monocytes the mice protected against MPTP induced TH expression in the gut but not in the striatum, in the meanwhile the microglia activation showed no difference in microglia activation in the brain. In addition, several studies have reported the causal relationship between IBD and PD in recent years (Lin et al, 2016; Fujioka et al, 2017; Wan et al, 2018; Zhu et al, 2019). Here, we analyzed the recent studies on the relationship between PD and intestinal disorders, and highlighted the potential underlying mechanisms of gut inflammation triggering PD.…”

Section: Introductionmentioning

confidence: 99%

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Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease

Chen

Haikal

et al. 2019

Front. Mol. Neurosci.

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Parkinson’s disease (PD) is a neurodegenerative disease that is generally thought to be caused by multiple factors, including environmental and genetic factors. Emerging evidence suggests that intestinal disturbances, such as constipation, are common non-motor symptoms of PD. Gut inflammation may be closely associated with pathogenesis in PD. This review aims to discuss the cross-talk between gut inflammation and PD pathology initiation and progression. Firstly, we will highlight the studies demonstrating how gut inflammation is related to PD. Secondly, we will analyze how gut inflammation spreads from the gastro-intestine to the brain. Here, we will mainly discuss the neural pathway of pathologic α-syn and the systemic inflammatory routes. Thereafter, we will address how alterations in the brain subsequently lead to dopaminergic neuron degeneration, in which oxidative stress, glutamate excitotoxicity, T cell driven inflammation and cyclooxygenase-2 (COX-2) are involved. We conclude a model of PD triggered by gut inflammation, which provides a new angle to understand the mechanisms of the disease.

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Section: Relationship Between Gut Inflammation and Pdmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease

Chen

Haikal

et al. 2019

Front. Mol. Neurosci.

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“…Several recent epidemiologic studies [27,28,29,30,31,32,33] have been conducted to determine whether IBD increases the risk of PD based on common biologic and genetic mechanisms described in the pathogenesis of IBD and PD. However, there is still controversy regarding the risk of PD in patients with IBD because increased health care use following a diagnosis of IBD is likely to act as a surveillance bias in interpreting a causal relationship between IBD and the risk of PD [34,35]. In addition, whether therapeutic agents for treating IBD lower the risk of developing PD remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study

Park

Kim

Chun

et al. 2019

JCM

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Background and Aims: It is not known whether inflammatory bowel disease (IBD) enhances the risk of Parkinson’s disease (PD) or whether PD diagnosis is the result of increased health care use. We determined the risk of developing PD among patients with IBD in terms of health care and medication use. Methods: A nationwide population-based study was conducted using claims data from the Korean National Health care Insurance service. From 2010 to 2013, patients with Crohn’s disease (CD) and ulcerative colitis (UC) were identified through both International Classification of Disease, Tenth Revision (ICD-10) and national rare intractable disease (RID) registration program codes. We compared 38,861 IBD patients with age and sex-matched non-IBD individuals at a ratio of 1:3. Patients with newly diagnosed PD were identified through both ICD-10 and RID codes. Results: The incidence of PD among patients with IBD was 49 per 100,000 person-years. The risk of developing PD in patients with IBD was significantly higher than controls even after adjustment for health care use (adjusted hazard ratio (aHR), 1.87; P < 0.001). Compared to controls, the risk of PD was significantly higher in patients with CD (aHR, 2.23; P = 0.023) and UC (aHR, 1.85; P < 0.001). Corticosteroid use showed a preventive effect on developing PD in patients with CD (aHR 0.08; P < 0.001), but not UC (aHR, 0.75; P = 0.213). Among 2110 patients receiving anti-tumor necrosis factor (anti-TNF), none of the treated patients experienced PD during 9950 person-years. Conclusion: Patients with IBD are at an increased risk of PD, regardless of health care use. Corticosteroid and anti-TNF use may prevent PD in patients with IBD.

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“…For each health outcome, the median number of the meta-analysis was 1. The median number of primary studies for each evidence was 4 (range [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. The associations between IBD (CD and UC) and cancer outcomes are shown in Table 1 .…”

Section: Search Resultsmentioning

confidence: 99%

“…For example, a meta-analysis [9] reported that patients with CD had a higher risk of lymphoma while another meta-analysis [10] found that CD did not increase the risk of lymphoma. Furthermore, a meta-analysis of 4 studies [11] indicated that the overall risk of Parkinson disease in patients with IBD was higher than controls while another meta-analysis of 5 studies [12] indicated that patients with IBD did not have an increased risk of Parkinson disease.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel diseases and the risk of adverse health outcomes: Umbrella review of meta-analyses of observational studies

Shen

Wan

Zhao

et al. 2021

Digestive and Liver Disease

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Background and Aim: Accumulating evidence indicates a plausible association between inflammatory bowel diseases and the risk of adverse health outcomes. However, the conclusions are inconsistent. We aimed to perform an umbrella review of meta-analyses to appraise and grade the evidence of the association between inflammatory bowel diseases and the risk of adverse health outcomes. Methods: Meta-analyses of observational studies that examined the associations between inflammatory bowel disease and the risk of adverse health outcomes in PubMed, EMBASE, and Web of Science were screened. Results: This umbrella review identified 25 meta-analyses, which yielded 123 effect estimates for 60 unique putative health outcomes. Patients with inflammatory bowel diseases had a higher risk of adverse health outcomes, including multiple cancers, cardiovascular disease, adverse pregnancy outcomes, adverse oral outcomes, and other adverse events. Moreover, inflammatory bowel diseases caused greater harm to health based on the presented evidence. However, none of the evidence was classified as "high" quality, only 15% was classified as "moderate," and 65% of outcomes were rated as "very low." Conclusion: Patients with inflammatory bowel diseases had a higher risk of adverse health outcomes and further studies should be conducted to draw firmer conclusions.

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Older patients with IBD might have higher risk of Parkinson’s disease

Cited by 27 publications

References 9 publications

Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease

Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease

Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study

Inflammatory bowel diseases and the risk of adverse health outcomes: Umbrella review of meta-analyses of observational studies

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