Strategies of anti-ageing promise eternal youth and necessitate an ethical foundation of this process. With the help of a hypotheses controlled literature research, this descriptive study considers the poles of happiness and death under psychiatric-ethical aspects. In the Western world the association of age and physical deficits is mostly present. Exemplary, the wrinkle treatment represents the immense actual efforts in reducing the deficits accompanying the process of ageing. Actually, Botox as a well-known anti-ageing nerval toxin is also applied as an antidepressant therapy. The authors call for caution at this, because psychiatry, psychosomatics and psychotherapy dispose well-established alternative antidepressive methods like promoting the factor of resilience at an early stage whereby the self-perceived success in ageing can be enhanced. Besides resilience, humour, self-validation and gratitude should be recognised. Further studies are needed for an evaluation of thanatologic interventions in psychotherapy.