Oldest bone disease

Rothschild, Bruce M.; Thillaud, Pierre L.

doi:10.1038/349288a0

Cited by 12 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of calcium pyrophosphate deposition disease was also determined, as it is sometimes confused/misclassified with osteoarthritis (Rothschild and Martin, 1993). Calcium pyrophosphate deposition disease (CPPD) was recognized if a calcified sheet reflecting onto the articular surface was present (Genant, 1976;Markel and Hart, 1982;Resnick and Niwayama, 1988;Rothschild, 1982;Rothschild and Thillaud, 1991).…”

Section: Identification Of Porosity and Osteoarthritismentioning

confidence: 99%

Porosity: A curiosity without diagnostic significance

Rothschild

1997

Am. J. Phys. Anthropol.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Identification Of Porosity and Osteoarthritismentioning

confidence: 99%

Porosity: A curiosity without diagnostic significance

Rothschild

1997

Am. J. Phys. Anthropol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similarly, the scapula AT-2563+AT-2471 shows a peripheral ridge in the glenoid cavity (not shown) that is apparently the result of mineralization of the fibrocartilagenous glenoid lambrum. Such a peripheral ridge is also identified in La Chapelle-aux-Saints and Shanidar I Neanderthals 54 . CPPD (Calcium pyrophosphate dihydrate crystal deposition disease/chondrocalcinosis) is most common in annulus fibrosus of the intervertebral disc and glenoid labra among many sites [55][56][57] .…”

Section: Cppdmentioning

confidence: 65%

“…17), present a ragged porotic shaft with 'bumpy' irregularities as a result of an extensive subperiosteal "lacelike" resorption (SPR) laterally, medially (cf. 44,54,122 ) and on the palmar surface (cf. 122 ) that has affected extensively the cortical bone.…”

Section: Phalangeal Resorptionmentioning

confidence: 99%

Hibernation, puberty and chronic kidney disease in troglodytes from Spain half a million years ago

Bartsiokas

Arsuaga

2018

Preprint

View full text Add to dashboard Cite

Both animal hibernation (heterothermy) and human renal osteodystrophy are characterized by high levels of serum parathyroid hormone. To test the hypothesis of hibernation in an extinct human species, we examined the hominin skeletal collection from Sima de los Huesos, Cave Mayor, Atapuerca, Spain, for evidence of hyperparathyroidism. We studied the morphology of the fossilized bones by using macrophotography, microscopy, histology and CT scanning. We found trabecular tunneling and osteitis fibrosa, subperiosteal resorption,‘rotten fence post’ signs,brown tumours, subperiosteal new bone, chondrocalcinosis, rachitic osteoplaques and empty gaps between them, craniotabes, and beading in ribs mostly in the adolescent population of these hominins. Since many of the above lesions are pathognomonic, these extinct hominins suffered annually from renal rickets, secondary hyperparathyroidism, and renal osteodystrophy associated with Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). We suggest these diseases were caused by non-tolerated hibernation in dark cavernous hibernacula. This is evidenced by the rachitic osteoplaques and the gaps between them mainly in the adolescent individuals along with the evidence of healing mainly in the adults. The sublayers in the rachitic osteoplaques point to bouts of arousal from hibernation. The strong projection of the external lip of the femoral trochlea, the rachitic osteoplaques with the empty gaps between them,the “rotten fence post sign”, and the evidence of annual healing caused by non-tolerated hibernation in adolescent individuals, also point to the presence of annually intermittent puberty in this population. The hypothesis of hibernation is consistent with the genetic evidence and the fact that the SH hominins lived during a glacial period. The present work will provide a new insight into the physiological mechanism of early human metabolism which could help in determining the life histories and physiologies of extinct human species.

show abstract

“…CPPD was identified on the basis of notation of a calcified shelf or its residua (Markel and Hart, 1982;Moskowitz et al, 1984;Resnick and Niwayama, 1988;Rothschild, 1982;Rothschild and Thillaud, 1991;Yosipovitch and Glimcher, 1972). The distribution pattern of osteoarthritis in atypical locations was not utilized as a diagnostic criterion in this study, as typical patterns of osteoarthritis are not fully established for non-human primates.…”

mentioning

confidence: 99%

“…Osteoarthritis was identified on the basis of synovial-lined joint remodeling with spur (osteophyte) formation, increase in density of the subchondral plate (sclerosis), or formation of small interosseous distal metaphyseal cysts (Jurmain, 1977(Jurmain, , 1989Moskowitz et al, 1984;Resnick and Niwayama, 1988;Rothschild, 1982;Woods, 1986). CPPD was identified on the basis of notation of a calcified shelf or its residua (Markel and Hart, 1982;Moskowitz et al, 1984;Resnick and Niwayama, 1988;Rothschild, 1982;Rothschild and Thillaud, 1991;Yosipovitch and Glimcher, 1972). The distribution pattern of osteoarthritis in atypical locations was not utilized as a diagnostic criterion in this study, as typical patterns of osteoarthritis are not fully established for non-human primates.…”

mentioning

confidence: 99%

Osteoarthritis, calcium pyrophosphate deposition disease, and osseous infection in old world primates

Rothschild

Woods

1992

American J Phys Anthropol

Self Cite

View full text Add to dashboard Cite

Uncertainties as to the nature and implications of osteoarthritis and calcium pyrophosphate deposition disease (CPPD) in primates were subject to critical review through examination of 153 prosimians and 1,250 Old World non-prosimian primates. Osteoarthritis, calcium pyrophosphate deposition disease, and infectious arthritis/osteomyelitis were relatively rare phenomena, affecting only 1.7% and 2.5%, respectively, of free-ranging prosimians and other Old World non-prosimian primates. Frequency of infection in Indri and Presbytis appears to reflect a unique susceptibility or exposure. Papio may have a unique predisposition to CPPD. The dichotomy (frequency and joint distribution) between free-ranging and artificially restrained animals suggests caution in interpretation of osteoarthritis or CPPD in non-free-ranging animals.

show abstract

Oldest bone disease

Cited by 12 publications

References 2 publications

Porosity: A curiosity without diagnostic significance

Porosity: A curiosity without diagnostic significance

Hibernation, puberty and chronic kidney disease in troglodytes from Spain half a million years ago

Osteoarthritis, calcium pyrophosphate deposition disease, and osseous infection in old world primates

Contact Info

Product

Resources

About