Olea europaea Leaf Phenolics Oleuropein, Hydroxytyrosol, Tyrosol, and Rutin Induce Apoptosis and Additionally Affect Temozolomide against Glioblastoma: In Particular, Oleuropein Inhibits Spheroid Growth by Attenuating Stem-like Cell Phenotype

Erçelik, Melis; Tekin, Çağla; Tezcan, Gulcin; Aksoy, Seçil Ak; Bekâr, Ahmet; Kocaelı, Hasan; Taşkapılıoğlu, Mevlüt Özgür; Ocak, Pınar Eser; Tunca, Berrin

doi:10.3390/life13020470

Cited by 11 publications

(2 citation statements)

References 66 publications

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“…A wound-healing assay analyzed cell recovery as described previously (Ercelik et al, 2023). Brie y, HT-29 cells, which were plated into a 6-well plate, were scratched by a 100 µL pipette tip, and the debris was removed.…”

Section: Evaluation Of Colon Cell Recoverymentioning

confidence: 99%

Myricetin suppressed DSS-induced colitis and promoted the therapeutic success of Infliximab in TNBS-induced colitis

Camlibel,

Ferah,

Gurbuz

et al. 2024

Preprint

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Infliximab (IFX) is widely used in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). Still, long-term use may be ineffective or suggest some side effects. This study investigated the role of Myricetin, a flavonoid, alone and its complementary therapeutic potential in combination with IFX against UC, CH, and cancerization. DSS triggered the development of acute UC syndromes in Wistar albino rats, while TNBS treatment triggered some of the symptoms seen in CD. The effectiveness of IFX, Myricetin, and their combination against UC and CD was determined by the disease activity index and changes in TNF-α secretion. The effect of IFX and Myricetin on tumor aggressiveness was evaluated by in vitro wound healing and colony formation analysis and expression of NF-κB and COX2 genes in a colon cancer cell line. Myricetin strongly reduced NF-κB expression in the DSS-induced UC model (p < 0.0001), but this effect was weaker in the TNBS-induced CD model, while COX2 expression was the opposite. Myricetin was beneficial as a complement to IFX in the CD model, while also promoting the improvement of clinical symptoms of the acute UC model (p < 0.05). Myricetin slowed down wound healing and colony formation of HT-29 cells and attenuated NF-κB expression. Myricetin may promise an alternative treatment approach in acute UC. Additionally, CD cases may benefit from Myricetin only when used in conjunction with IFX.

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Section: Evaluation Of Colon Cell Recoverymentioning

confidence: 99%

Myricetin suppressed DSS-induced colitis and promoted the therapeutic success of Infliximab in TNBS-induced colitis

Camlibel,

Ferah,

Gurbuz

et al. 2024

Preprint

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“…This compound has been shown to exhibit a wide range of biological activities, including antioxidant, anti-inflammatory, and anti-cancer effects [11,12]. Other phenolic compounds found in olive leaves, such as hydroxytyrosol and tyrosol, also have strong antioxidant and antiinflammatory properties and have been linked to numerous health benefits, including reduced risk of cardiovascular disease, neurodegenerative disorders, and certain types of cancer [13,14]. Olive leaf phenolic content might vary based on the cultivar, harvest period, and extraction technique.…”

Section: Introductionmentioning

confidence: 99%

Resin Adsorption of Phenolic Compounds from Olive Leaf and Coffee Residue Extracts: Batch and Packed Column Adsorption Experimental Investigation and Mathematical Modeling

Kodjapashis,

Zentelis,

Zagklis

et al. 2023

Separations

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Phenolic compounds are important secondary metabolites often found in nature, and most prominently in plants. Plant biomass residues can be a sustainable source of this high-added-value group of compounds that can be used in the food and cosmetics industries due to their antioxidant properties. Olea europaea is a widely studied source of phenolic compounds, with olive leaves being an untapped solid residue with high phenolic content. Coffee residues after coffee extraction is another biomass residue stream rich in phenols. In this work, phenolic extracts of these two substrates, alongside different fractions produced through ultrafiltration and nanofiltration, were examined in resin adsorption experiments. Amberlite XAD16N was used as adsorbent in both batch and packed column experiments, with the experimental results being fitted with mathematical models for batch kinetics, adsorption isotherms, and column adsorption. The tested adsorbent proved capable of separating the target compounds, exhibiting a capacity of 72 mg of olive leaf phenols from nanofiltration retentate per g of resin in batch adsorption experiments, second order kinetics better described the batch adsorption process, while the use of the Thomas model sufficiently described the continuous adsorption process in packed columns (R2 > 0.9).

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A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges

Pasdaran,

Grice,

Hamedi

2024

Drug Development Research

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In 2021, the World Health Organization released the fifth edition of the central nervous system (CNS) tumor classification. This classification uses histopathology and molecular pathogenesis to group tumors into more biologically and molecularly defined entities. The prognosis of brain cancer, particularly malignant tumors, has remained poor worldwide, approximately 308,102 new cases of brain and other CNS tumors were diagnosed in the year 2020, with an estimated 251,329 deaths. The cost and time‐consuming nature of studies to find new anticancer agents makes it necessary to have well‐designed studies. In the present study, the pathways that can be targeted for drug development are discussed in detail. Some of the important cellular origins, signaling, and pathways involved in the efficacy of bioactive molecules against CNS tumorigenesis or progression, as well as prognosis and common approaches for treatment of different types of brain tumors, are reviewed. Moreover, different study tools, including cell lines, in vitro, in vivo, and clinical trial challenges, are discussed. In addition, in this article, natural products as one of the most important sources for finding new chemotherapeutics were reviewed and over 700 reported molecules with efficacy against CNS cancer cells are gathered and classified according to their structure. Based on the clinical trials that have been registered, very few of these natural or semi‐synthetic derivatives have been studied in humans. The review can help researchers understand the involved mechanisms and design new goal‐oriented studies for drug development against CNS malignancies.

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Olea europaea Leaf Phenolics Oleuropein, Hydroxytyrosol, Tyrosol, and Rutin Induce Apoptosis and Additionally Affect Temozolomide against Glioblastoma: In Particular, Oleuropein Inhibits Spheroid Growth by Attenuating Stem-like Cell Phenotype

Cited by 11 publications

References 66 publications

Myricetin suppressed DSS-induced colitis and promoted the therapeutic success of Infliximab in TNBS-induced colitis

Myricetin suppressed DSS-induced colitis and promoted the therapeutic success of Infliximab in TNBS-induced colitis

Resin Adsorption of Phenolic Compounds from Olive Leaf and Coffee Residue Extracts: Batch and Packed Column Adsorption Experimental Investigation and Mathematical Modeling

A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges

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