Oleacein may inhibit destabilization of carotid plaques from hypertensive patients. Impact on high mobility group protein-1

Filipek, Agnieszka; Czerwińska, Monika E.; Kiss, Anna K.; Polański, Jerzy A.; Naruszewicz, Marek

doi:10.1016/j.phymed.2017.06.004

Cited by 37 publications

(25 citation statements)

References 27 publications

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“…Later, these authors reported the beneficial effects of OLA in attenuating the destabilization of carotid plaque in 20 patients with hypertension. This work revealed the ability of OLA to modulate IL-10, HO-1, MMP-9, and high mobility group protein-1, which is a specific biomarker of cell lethality [166]. Thus, this compound could be potentially useful in the reduction of ischemic stroke risk.…”

Section: Ol-aglyconementioning

confidence: 88%

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases

et al. 2020

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Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c] pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring leads to secoiridoids. Mainly, secoiridoids have shown a variety of pharmacological effects including anti-diabetic, antioxidant, anti-inflammatory, immunosuppressive, neuroprotective, anti-cancer, and anti-obesity, which increase the interest of studying these types of bioactive compounds in depth. Secoiridoids are thoroughly distributed in several families of plants such as Oleaceae, Valerianaceae, Gentianaceae and Pedialaceae, among others. Specifically, Olea europaea L. (Oleaceae) is rich in oleuropein (OL), dimethyl-OL, and ligstroside secoiridoids, and their hydrolysis derivatives are mostly OL-aglycone, oleocanthal (OLE), oleacein (OLA), elenolate, oleoside-11-methyl ester, elenoic acid, hydroxytyrosol (HTy), and tyrosol (Ty). These compounds have proved their efficacy in the management of diabetes, cardiovascular and neurodegenerative disorders, cancer, and viral and microbial infections. Particularly, the antioxidant, anti-inflammatory, and immunomodulatory properties of secoiridoids from the olive tree (Olea europaea L. (Oleaceae)) have been suggested as a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases. Thus, the purpose of this review is to summarize recent advances in the protective role of secoiridoids derived from the olive tree (preclinical studies and clinical trials) in diseases with an important pathogenic contribution of oxidative and peroxidative stress and damage, focusing on their plausible mechanisms of the action involved.

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Section: Ol-aglyconementioning

confidence: 88%

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases

et al. 2020

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“…Another recent and interesting finding in biological action of oleacein is the attenuation of carotid plaque destabilization. This action could be useful in cases of ischemic stroke, as could reduce the risk of the disease [84].…”

Section: Oleaceinmentioning

confidence: 99%

Olive Oil Phenols

Papanikolaou¹,

Melliou²,

Magiatis³

2019

Functional Foods

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Olive oils contain numerous substances that have a beneficial role in human health. Phenols are natural compounds that are present in extra-virgin olive oil (EVOO), and they are produced at the malaxation step of the olive oil production. The four most abundant phenols in EVOO are oleocanthal, oleacein, ligstroside aglycon, and oleuropein aglycon. These phenols exhibit significant biological effects in many diseases, participating in various cellular and biochemical processes. Oleocanthal can protect and prevent against the Alzheimer disease, demonstrates acute antiplatelet effects, which has a vital role against cancer, and can act like ibuprofen. Oleacein has antioxidant and anti-inflammatory activities and helps against atherosclerosis. Moreover, it acts as an antiaging factor and as a 5-lipoxygenase inhibitor. Ligstroside aglycon implicates to mechanisms against breast cancer, while oleuropein aglycon shows activities against the Alzheimer disease and breast cancer.

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“…Although no drugs targeting HMGB-1 were used in clinical practice, some anti-HMGB-1 agents were shown to inhibit the expression of HMGB-1 in ischemic animal models, including glycyrrhizin [90,149,150], ethyl pyruvate (EP) [151,152], tanshinone IIA [153,154], fluvastatin [155], berberine [156], moclobemide [157], minocycline [158], probenecid [159], portulaca [160], apelin-13 [161], hesperidin [162] and bleacein [163]. Glycyrrhizin, a glycoconjugated triterpene present in licorice root, has been shown to exert protective effects in various diseases via suppressing HMGB-1.…”

Section: Therapeutic Strategy For Hmgb-1mentioning

confidence: 99%

“…In addition, tanshinone IIA [154]but not IL-23 [164] dose-dependently improved the cardiac function and decreased HMGB-1 levels in myocardial injury induced by ischemia-reperfusion . A recent report by Filipek et al showed that oleacein could attenuate the destabilization of carotid plaque in hypertensive patients, suggesting its role in the reduction of the risk of ischemic stroke [163]. Several agents have protective effects on ischemic injury via inhibition of HMGB-1.…”

Section: Therapeutic Strategy For Hmgb-1mentioning

confidence: 99%

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

Pei

et al. 2018

Cell Physiol Biochem

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High mobility group box-1 (HMGB-1), a typical damage-associated molecular pattern protein released from various cells, was first identified in 1973. It is usually stored in the nuclei of cells. Several modifications of HMGB-1 promote its translocation to the cytosol, and it is actively or passively released from cells. When outside of the cells, HMGB-1is crucial in inflammation. It exerts its biological functions via interaction with its receptors, including receptor for advanced glycation end products (RAGE) and Toll-like receptor 4(TLR4). A large number of studies showed a close link between inflammation and thrombosis. This review demonstrated the increased expression of HMGB-1 in thrombosis-related diseases, including coronary artery disease, stroke, peripheral arterial disease, disseminated intravascular coagulation, and venous thrombosis. Besides, it summarized the current understanding of the emerging link between HMGB-1 and thrombosis from three aspects: platelet, NETs, and coagulation and fibrinolysis factors. Finally, it explored the possible therapeutic strategies targeting HMGB-1 for treating thrombosis-related diseases.

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Oleacein may inhibit destabilization of carotid plaques from hypertensive patients. Impact on high mobility group protein-1

Cited by 37 publications

References 27 publications

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases

Olive Oil Phenols

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

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