Oleanolic Acid-3-(1′2′Orthoacetate-Glucoside)-28-Glucoside Alleviates Methylmercury Toxicity &lt;i&gt;in Vitro&lt;/i&gt; and &lt;i&gt;in Vivo&lt;/i&gt;

Nakamura, Ryosuke; Shirahata, Tatsuya; Katsumi, Tatsuya; Konishi, Naruki; Takanezawa, Yasukazu; Ohshiro, Yuka; Uraguchi, Shimpei; Kobayashi, Yoshinori; Kiyono, Masako

doi:10.1248/bpbreports.2.4_56

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…These results suggested that OA3Glu would be a potential anti-MeHg toxicity compound. 21,22) Recently, we exposed mice to MeHg at a higher concentration than the previous reports and verified the effect of OA3Glu, as an anti-MeHg toxicity compound especially focusing on dynamic weight bearing test and electrophysiology in MeHg-exposed mice. OA3Glu can alleviate MeHg-induced Purkinje cell death and synaptic damage (unpublished data).…”

Section: Protective Effect Of Oleanolic Acid-3-glucoside On Methylmer...supporting

confidence: 53%

Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health

et al. 2023

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The history of methylmercury (MeHg) toxicity research goes back to Minamata disease. In Japan, histopathological examination of patients afflicted with Minamata disease, alongside meticulous investigations at both in vitro and in vivo, were robustly undertaken to elucidate the deleterious effects of MeHg. It is not an overstatement to assert that Japanese investigations on MeHg toxicity have spearheaded global advancements in this field. Nevertheless, more than half a century has passed since the onset of Minamata disease, yet the intricacies of MeHg toxicity remains enigmatic. Moreover, environmental pollution of mercury and toxic metals is a global problem that needs to be solved. Therefore, our research has focused on, "toxicology of MeHg" and "remediation of mercury and other toxic metals". This review discusses the molecular mechanisms underlying roles of autophagy in MeHg responses of mammalian cells, identification of an anti-MeHg natural product, analysis of bacterial mercury-resistant gene, and plant biotechnology using bacterial transporters for phytoremediation.

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Section: Protective Effect Of Oleanolic Acid-3-glucoside On Methylmer...supporting

confidence: 53%

Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health

et al. 2023

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Efficient synthesis of diverse C-3 monodesmosidic saponins by a continuous microfluidic glycosylation/batch deprotection method

Konishi

Shirahata

Yoshida

et al. 2021

Carbohydrate Research

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Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice

Nakamura,

Iwai,

Takanezawa

et al. 2024

Toxicology

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Oleanolic Acid-3-(1′2′Orthoacetate-Glucoside)-28-Glucoside Alleviates Methylmercury Toxicity <i>in Vitro</i> and <i>in Vivo</i>

Cited by 3 publications

References 29 publications

Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health

Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health

Efficient synthesis of diverse C-3 monodesmosidic saponins by a continuous microfluidic glycosylation/batch deprotection method

Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice

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