Oleanolic acid and ursolic acid: Research perspectives

Liu, Jie

doi:10.1016/j.jep.2005.05.024

Cited by 645 publications

(384 citation statements)

References 12 publications

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“…In addition, seven proteins with anti‐cancer functions (Black circles) and the other seven proteins with anti‐diabetes functions (Pink circles), respectively. These results were consistent with previous studies of UA activity 13. We then used AutoDock 4.0 software to conduct molecular docking studies to evaluate the interaction between anti‐inflammatory targets and UA.…”

Section: Resultssupporting

confidence: 88%

“…demonstrated that UA can improve insulin signaling, reduce oxidative stress and inhibit proinflammatory signaling, which collectively imply an application to diabetes therapy 11. Although all the evidence has shown that UA is a potential candidate for the development of a comprehensive strategy for the treatment and prevention of health disorders,12 and the well‐investigated anti‐inflammatory, anti‐cancer effects and metabolic syndrome have been presented,13 there are few studies that have investigated the specific targets and molecular mechanism of UA.…”

Section: Introductionmentioning

confidence: 99%

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Ursolic Acid, a Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation‐Associated Downstream Signal Transduction

Yuan

Wang

et al. 2017

Molecular Nutrition Food Res

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ScopeUrsolic acid (UA) is a pentacyclicterpenoid carboxylic acid that is present in a wide variety of plant foods. There are many beneficial health effects that are attributed to the properties of UA. However, the specific cellular targets of UA and the mechanism underlying downstream signal transduction processes linked to the anti‐inflammation pathway have not been thoroughly elucidated to date.Methods and resultsChemical biology strategies such as target fishing, click reaction synthesis of a UA probe and molecular imaging were used to identify potential target proteins of UA. Cysteinyl aspartate specific proteinase 3 (CASP3) and its downstream signaling pathway were verified as potential targets by molecular docking, intracellular enzyme activity evaluation and accurate pathway analysis. The results indicated that UA acted on CASP3, ERK1 and JNK2 targets, alleviated inflammation‐associated downstream multiple signal transduction factors, including ERK1, NF‐κB and STAT3, and exhibited anti‐inflammation activities.ConclusionAs a natural dietary supplement, UA demonstrated anti‐inflammation activity via inhibition of CASP3 and shows the potential to improve the therapy effect of several inflammation‐associated diseases.

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Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Ursolic Acid, a Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation‐Associated Downstream Signal Transduction

Yuan

Wang

et al. 2017

Molecular Nutrition Food Res

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“…[6]. Oleanolic acid (OA), a natural pentacyclic triterpene widely found in a variety of plants, has been shown to display numerous biological properties with therapeutic potential [7,8]. It is present in the leaves and fruits of Olea europaea, among other vegetables.…”

Section: Introductionmentioning

confidence: 99%

Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role

Martín

Carvalho‐Tavares

Hernández

et al. 2010

Biochemical Pharmacology

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Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease for which there exist no therapies without undesired side effects. Thus, the establishment of less toxic treatments is an ongoing challenge. Nowadays, research on medicinal plants has been attracting much attention, since screening of its active principles could prove useful in identification of safe and innovative pharmaceutical molecules. In this study we investigated the therapeutic effect of oleanolic acid (OA) a plant-derived triterpene with potent anti-inflammatory and immunomodulatory activities, whose actions on CNS diseases remain far from completely characterized. We focussed on the potential therapeutic effect of oleanolic acid (OA) on an accepted experimental model of MS, the experimental autoimmune encephalomyelitis (EAE).We have found that OA treatment, before or at the early onset of EAE, ameliorates neurological signs of EAE-mice. These beneficial effects of OA seem to be associated with a reduction of blood-brain barrier leakage and lower infiltration of inflammatory cells within the CNS, as well as with its modulatory role in Th1/Th2 polarization: inhibition of proinflammatory cytokines and chemokines, and stimulation of anti-inflammatory ones.Moreover, EAE-animals that were treated with OA had lower levels of anti-MOG antibodies than untreated EAE-mice.Our findings show that the administration of the natural triterpenoid OA reduces and limits the severity and development of EAE. Therefore, OA therapy might be of clinical interest for human MS and other Th1 cell-mediated inflammatory diseases.

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“…In vitro studies using a variety of tumor cell lines have demonstrated the usefulness of ursolic acid in chemoprevention and in the treatment of inflammation-driven disease (Table 1). Although ursolic acid has been shown to prevent a variety of inflammation-associated diseases, the exact molecular mechanism is yet to be elucidated [27][28][29]. Ursolic acid has been previously reported to suppress the proliferation of a number of tumor cells, induce apoptosis [30] and inhibit tumor promotion, metastasis, and angiogenesis [31].…”

Section: In Vitro Anticancer Effects Of Ursolic Acidmentioning

confidence: 99%

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

Shanmugam

Dai

Kumar

et al. 2013

Biochemical Pharmacology

292

205

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Oleanolic acid and ursolic acid: Research perspectives

Cited by 645 publications

References 12 publications

Ursolic Acid, a Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation‐Associated Downstream Signal Transduction

Ursolic Acid, a Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation‐Associated Downstream Signal Transduction

Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

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