Oleanolic Acid Complexation with Cyclodextrins Improves Its Cell Bio-Availability and Biological Activities for Cell Migration

Stelling-Férez, Javier; López-Miranda, Santiago; Gabaldón, José Antonio; Nicolás, Francisco José

doi:10.3390/ijms241914860

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…To address this, there have been some studies combining OA with nanomaterials or using OA as an adjuvant to improve its bioavailability. Férez et al [ 164 ] used cyclodextrins to encapsulate OA, and the results show that OA-encapsulated compounds have advantages over unencapsulated OA in terms of chemical stability, the promotion of cell migration, and the preservation of cell viability. A solidified phospholipid complex composed of an OA–phospholipid complex and hydroxyapatite has been developed, which has increased the oral availability of OA to 240% [ 165 ].…”

Section: Metabolism Bioavailability and Clinical Potential Of Oamentioning

confidence: 99%

The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases

Luo,

Wei,

et al. 2024

Molecules

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Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs’ initiation and development. Although there are many availabile drugs for treating MetS and related CVDs, some side effects also occur. Considering the low-level side effects, many natural products have been tried to treat MetS and CVDs. A five-cyclic triterpenoid natural product, oleanolic acid (OA), has been reported to have many pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, and liver protection. OA has specific advantages in the treatment of MetS and CVDs. OA achieves therapeutic effects through a variety of pathways, attracting great interest and playing a vital role in the treatment of MetS and CVDs. Consequently, in this article, we aim to review the pharmacological actions and potential mechanisms of OA in treating MetS and related CVDs.

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Section: Metabolism Bioavailability and Clinical Potential Of Oamentioning

confidence: 99%

The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases

Luo,

Wei,

et al. 2024

Molecules

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Refrigerated amniotic membrane maintains its therapeutic qualities for 48 hours

Stelling-Férez,

Puente-Cuadrado,

Álvarez-Yepes

et al. 2024

Front. Bioeng. Biotechnol.

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During wound healing, the migration of keratinocytes is critical for wound closure. The application of amniotic membrane (AM) on wounds with challenging contexts (e.g., chronification and diabetic foot ulcer) has proven very successful. However, the use of AM for clinical practice has several restraints when applied to patients; the most important restriction is preserving AM’s therapeutic properties between its thawing and application onto the patient’s wound. Moreover, AM collection and processing requires a cleanroom, together with specialized staff and equipment, and facilities that are not usually available in many hospitals and healthcare units. In this publication, we kept previously cryopreserved AM at different temperatures (37°C, 20°C, and 4°C) in different media (DMEM high glucose and saline solution with or without human albumin) and for long incubation time periods after thawing (24 h and 48 h). HaCaT keratinocytes and TGF-β1-chronified HaCaT keratinocytes were used to measure several parameters related to wound healing: migration, cell cycle arrest rescue, and the expression of key genes and migration-related proteins. Our findings indicate that AM kept in physiological saline solution at 4°C for 24 h or 48 h performed excellently in promoting HaCaT cell migration compared to AM that had been immediately thawed (0 h). Indeed, key proteins, extracellular signal-regulated kinase (ERK) and c-Jun, were induced by AM at 4°C in saline solution. Similarly, cell proliferation and different genes related to survival, inflammation, and senescence had, in all cases, the same response as to standard AM. These data suggest that the handling method in saline solution at 4°C does not interfere with AM’s therapeutic properties.

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Oleanolic Acid Complexation with Cyclodextrins Improves Its Cell Bio-Availability and Biological Activities for Cell Migration

Cited by 2 publications

References 89 publications

The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases

The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases

Refrigerated amniotic membrane maintains its therapeutic qualities for 48 hours

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