Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts

Wu, Pui Kei; Tai, William; Liang, Zhitao; Zhao, Zhongzhen; Hsiao, W.L. Wendy

doi:10.1016/j.lfs.2009.04.025

Cited by 37 publications

(22 citation statements)

References 31 publications

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“…To date, twenty-three phenolic acids (87-109) have been identified from the herb of H. Diffusa, including four benzoic acid derivatives (87)(88)(89)(90), coumaric acid (91) …”

Section: Phenolic Acids and Their Derivativesmentioning

confidence: 99%

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The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

et al. 2016

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Hedyotis diffusa Willd (H. diffusa) is a well-known Chinese medicine with a variety of activities, especially its anti-cancer effect in the clinic. Up to now, 171 compounds have been reported from H. diffusa, including 32 iridoids, 26 flavonoids, 24 anthraquinones, 26 phenolics and their derivatives, 50 volatile oils and 13 miscellaneous compounds. In vitro and in vivo studies show these phytochemicals and plant extracts to exhibit a range of pharmacological activities of anti-cancer, antioxidant, anti-inflammatory, anti-fibroblast, immunomodulatory and neuroprotective effects. Although a series of methods have been established for the quality control of H. diffusa, a feasible and reliable approach is still needed in consideration of its botanical origin, collecting time and bioactive effects. Meanwhile, more pharmacokinetics researches are needed to illustrate the characteristics of H. diffusa in vivo. The present review aims to provide up-to-date and comprehensive information on the phytochemistry, pharmacology, quality control and pharmacokinetic characteristics of H. diffusa for its clinical use and further development.

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“…To date, twenty-three phenolic acids (87-109) have been identified from the herb of H. Diffusa, including four benzoic acid derivatives (87)(88)(89)(90), coumaric acid (91) …”

Section: Phenolic Acids and Their Derivativesmentioning

confidence: 99%

“…Wu et al [89] found the inhibitory effect of oleanolic acid (2 and 8 µg/mL) isolated from H. diffusa against ras-transformed fibroblasts on R6 cells, and this inhibition might cause normal cells to secrete an inhibitory factor against the transformed cells, but did not require direct cell-cell contact.…”

Section: Othersmentioning

confidence: 99%

The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

et al. 2016

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“…Terpenoids, phenolics and alkaloids found in the extract showed antiproliferative activity but triterpenoids have highest antiproliferative activity than others. [105][106][107] …”

Section: Oldenlandia Diffusamentioning

confidence: 99%

Medicinal Plants for Treatment of Cancer: A Brief Review

Jain¹,

Dwivedi²,

Jain³

et al. 2016

phcogj

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“…A recent report showed that AEOD exhibits cancer cell-specific cytotoxicity in various types of human cancer cells, both in vivo and in vitro [11]. Furthermore, a recent study has shown that major components of O. diffusa, such as oleanolic and ursolic acids, also exhibit growth inhibition against Ras-transformed fibroblasts as well as anti-arthritic effects in acute and chronic arthritis models [12]. Nevertheless, the molecular mechanisms underlying the effects of AEOD on LPSstimulated inflammation are not well known.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Extract of <i>Oldenlandia diffusa</i> Suppresses LPS-Induced iNOS, COX-2 and TNF-α Expression in RAW 264.7 Cells via the NF-κB Activity

Jayasooriya¹,

Kang²,

Choi³

et al. 2011

Trop. J. Pharm Res

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Purpose: To elucidate the anti-inflammatory mechanisms of aqueous extract of Oldenlandia diffusa (AEOD) in cells. LPS-induced mRNA and protein expression of iNOS, COX-2 and TNF-α were attenuated by treatment with AEOD. These data imply that AEOD tightly regulates the expression of these inflammatory mediators at the transcriptional level. Therefore, we determined the effects of AEOD on nuclear factor-κB (NF-κB) activity, which has been considered to be a potential transcriptional factor for regulating the expression of iNOS, COX-2 and TNF-α. As expected, AEOD suppressed the LPS-induced degradation and phosphorylation of

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Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts

Cited by 37 publications

References 31 publications

The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

Medicinal Plants for Treatment of Cancer: A Brief Review

Aqueous Extract of <i>Oldenlandia diffusa</i> Suppresses LPS-Induced iNOS, COX-2 and TNF-α Expression in RAW 264.7 Cells via the NF-κB Activity

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