Oleanolic acid promotes skeletal muscle fiber type transformation by activating TGR5-mediated CaN signaling pathway

Liu, Shuang; Chen, Xiaoling; He, Jun; Luo, Yuheng; Zheng, Ping; Yu, Bing; Chen, Daiwen; Huang, Zhiqing

doi:10.1016/j.jnutbio.2023.109507

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…OA promoted conversion from fast to slow muscle fibers by activating the TGR5-mediated calcineurin/nuclear factor of activated T cells cytoplasmic 1 (NFATc1) pathway. Inhibiting TGR5 and calcineurin reversed OA’s effects on muscle fiber transformation [ 74 ]. The effects of OA on skeletal muscle production and proliferation of C2C12 cells were investigated.…”

Section: Pharmacological Activities Of Oamentioning

confidence: 99%

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Wasim,

Bergonzi

2024

Pharmaceutics

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The growing interest in oleanolic acid (OA) as a triterpenoid with remarkable health benefits prompts an emphasis on its efficient use in pharmaceutical research. OA exhibits a range of pharmacological effects, including antidiabetic, anti-inflammatory, immune-enhancing, gastroprotective, hepatoprotective, antitumor, and antiviral properties. While OA demonstrates diverse pharmacological effects, optimizing its therapeutic potential requires overcoming significant challenges. In the field of pharmaceutical research, the exploration of efficient drug delivery systems is essential to maximizing the therapeutic potential of bioactive compounds. Efficiently delivering OA faces challenges, such as poor aqueous solubility and restricted bioavailability, and to unlock its full therapeutic efficacy, novel formulation strategies are imperative. This discussion thoroughly investigates different approaches and advancements in OA drug delivery systems with the aim of enhancing the biopharmaceutical features and overall efficacy in diverse therapeutic contexts.

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Section: Pharmacological Activities Of Oamentioning

confidence: 99%

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Wasim,

Bergonzi

2024

Pharmaceutics

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“…This activation enhances glucose-stimulated insulin release in the pancreas and boosts energy expenditure, especially in skeletal muscles and brown adipose tissue. Moreover, in the brain, the signaling through TGR5 mediates satiety [37][38][39] (Figure 2). Additionally, BAs can influence the GM composition directly by disrupting bacterial membrane structures and indirectly by activating FXR, leading to the production of antimicrobial agents such as Inducible Nitric Oxide Synthase (iNOS) and interleukin-18 (IL-18) in the small intestine, consequently hindering bacterial growth [40,41].…”

Section: Bile Acidsmentioning

confidence: 99%

Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies

Marroncini,

Naldi,

Martinelli

et al. 2024

Biomedicines

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The functions of the gut are closely related to those of many other organs in the human body. Indeed, the gut microbiota (GM) metabolize several nutrients and compounds that, once released in the bloodstream, can reach distant organs, thus influencing the metabolic and inflammatory tone of the host. The main microbiota-derived metabolites responsible for the modulation of endocrine responses are short-chain fatty acids (SCFAs), bile acids and glucagon-like peptide 1 (GLP-1). These molecules can (i) regulate the pancreatic hormones (insulin and glucagon), (ii) increase glycogen synthesis in the liver, and (iii) boost energy expenditure, especially in skeletal muscles and brown adipose tissue. In other words, they are critical in maintaining glucose and lipid homeostasis. In GM dysbiosis, the imbalance of microbiota-related products can affect the proper endocrine and metabolic functions, including those related to the gut–liver–pancreas axis (GLPA). In addition, the dysbiosis can contribute to the onset of some diseases such as non-alcoholic steatohepatitis (NASH)/non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma (HCC), and type 2 diabetes (T2D). In this review, we explored the roles of the gut microbiota-derived metabolites and their involvement in onset and progression of these diseases. In addition, we detailed the main microbiota-modulating strategies that could improve the diseases’ development by restoring the healthy balance of the GLPA.

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Design and synthesis of unique indole-benzosulfonamide oleanolic acid derivatives as potent antibacterial agents against MRSA

Li,

Sun,

et al. 2024

European Journal of Medicinal Chemistry

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Oleanolic acid promotes skeletal muscle fiber type transformation by activating TGR5-mediated CaN signaling pathway

Cited by 4 publications

References 41 publications

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies

Design and synthesis of unique indole-benzosulfonamide oleanolic acid derivatives as potent antibacterial agents against MRSA

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