Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-α both in vitro and in vivo systems

Abstract

Background: Chronic inflammation is a key player in pathogenesis. The inflammatory cytokine, tumor necrosis factoralpha is a well known inflammatory protein, and has been a therapeutic target for the treatment of diseases such as Rheumatoid Arthritis and Crohn's Disease. Obesity is a well known risk factor for developing non-insulin dependent diabetes melitus. Adipose tissue has been shown to produce tumor necrosis factor-alpha, which has the ability to reduce insulin secretion and induce insulin resistance. Based on these observations, we sought to investigate the impact of unsaturated fatty acids such as oleic acid in the presence of TNF-α in terms of insulin production, the molecular mechanisms involved and the in vivo effect of a diet high in oleic acid on a mouse model of type II diabetes, KKA y .

Structure–activity relationship of immunomodulating pectins from elderberries

“…Oleic acid has also shown a beneficial effect on insulin sensitivity, adipocyte glucose transport and prevents T2D [62][63][64][65].…”

<i>In Vitro</i> Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i> and a Polyherb

“…FAMEs including oleic acid and α-linolenic acid were identified as the potential biomarkers of T2DM for their powerful discriminant ability of T2DM patients from healthy controls [23]. Addition of oleic acid in diet in Type 2 diabetic patients reduced insulin resistance and restored endothelium-dependent vasodilatation [24] and oleic acid was found to be effective in reversing the inhibitory effect in insulin production of the inflammatory cytokine tumor necrosis factor alpha (TNF-α) [25]. Studies have also shown that omega-3 fatty acids such as α-linolenic acid offer a direct or indirect reno-protective effect in diabetes patients [26].…”

Regular intake of high-oleic peanuts improves fat oxidation and body composition in overweight/obese men pursuing a energy-restricted diet

“…Thus, there is interest in producing and promoting the consumption of high-oleic peanuts to improve shelf-life without promoting the risk of obesity and its complications (6). High oleic acid peanuts may also reduce the negative metabolic effects of dietary saturated fatty acids (SFA) (8,9).…”