Oleic acid modulation of the immune response in wound healing: A new approach for skin repair

Cardoso, Cristina Ribeiro de Barros; Favoreto, Sílvio; Oliveira, Leandro Licursi de; Vancim, Jaqueline O.; Barban, G; Ferraz, D B; Silva, João

doi:10.1016/j.imbio.2010.06.007

Cited by 126 publications

(109 citation statements)

References 41 publications

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“…Collagen III mRNA levels were also increased in olive oil-fed mouse hearts in this study. This result is in agreement with an earlier study describing the same in MUFA-fed BALB/c mouse skin following wounding (56). We also show that olive oil did not induce gene levels of LOX proteins in mouse hearts.…”

Section: Discussionsupporting

confidence: 94%

Excess Linoleic Acid Increases Collagen I/III Ratio and “Stiffens” the Heart Muscle Following High Fat Diets

Beam

Botta

et al. 2015

Journal of Biological Chemistry

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Background: Dietary n-6 polyunsaturated fats (n-6 PUFA) like linoleic acid (LA) may worsen cardiac remodeling after injury. Results: Excess LA increased cardiac collagen I/III ratio and lysyl oxidase causing early diastolic dysfunction. In vitro experiments in fibroblasts with genetic manipulation confirmed such mechanisms. Conclusion: LA promotes noncompliant collagen and cardiac stiffening. Significance: This study demonstrates a novel, cardiac-specific lipotoxic pathway of n-6 PUFAs.

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Section: Discussionsupporting

confidence: 94%

Excess Linoleic Acid Increases Collagen I/III Ratio and “Stiffens” the Heart Muscle Following High Fat Diets

Beam

Botta

et al. 2015

Journal of Biological Chemistry

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“…47 Oleic acid also downregulated cyclooxygenase 2 (COX-2) and induced collagen type III expression in another study. 48 The same study also showed that omega-3 fatty acids accelerated early (5 days) closure of open wounds, although not as much as oleic acid. Interestingly, levels of tumor necrosis factor-a, interleukin-10 (IL-10), and IL-17 mRNA were significantly up regulated by oleic acid, whereas linoleic acid did not cause significant changes in these cytokines.…”

Section: Omega-3 Fatty Acids and Wound Healingmentioning

confidence: 85%

Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection

Wesley

Supp

2014

Advances in Wound Care

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“…These fatty acids showed a proinflammatory effect on cutaneous wound healing. Cardosoa et al 69 showed that linoleic and oleic acids can modulate the closure of surgically induced skin wounds.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Hamidi

Naeini

Oryan

et al. 2017

tjps

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ÖZAmaç: Bu çalışma, sıçanlarda oluşturulan deneysel yara modelinde Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun, enzimatik antioksidanlar üzerindeki etkisini araştırmak amacıyla yapılmıştır. Gereç ve Yöntemler: Genel anestezi altına alınan hayvanlarda, aseptik koşullarda, insizyon yapmak suretiyle kare şeklinde yaralar (2x2 cm) oluşturulmuştur. Daha sonra, hayvanlar rasgele dört gruba ayrılmıştır (I-tedavi edilmemiş kontrol grubu, II-haricen uygulanan baz jel grubu, IIIharicen %5 jel uygulanan grup, IV-haricen %10 jel uygulanan grup). Bulgular: Sonuçlar, Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun haricen uygulanmasının, kontrol ve baz jel gruplarına kıyasla, bütünlüğü bozulmamış stratum bazalisi, olgun granülasyon dokusunu, kıl folikülleri ve ter bezleri ile reepitelizasyonu arttırdığını göstermektedir. Yara oluşumundan 21 gün sonra, %10 yağlı jel ile tedavi edilen hayvanların dokularındaki gerilme kuvveti, kopma gerilimi ve bükülme direnci, kontrol ve baz jel grubu ile karşılaştırıldığında önemli ölçüde artmıştır. Aynı evredeki kontrol ve baz jel ile muamele edilen gruplara kıyasla, kollajen liflerin daha organize bir düzenlenme ve dokunun daha düzgün bir iyileşme gösterdiği belirlenmiştir. Sonuç: Pistacia atlantica yağ jelinin haricen uygulanmasının, sıçanlarda oluşturulan deneysel yaralar üzerinde morfolojik, biyokimyasal ve biyomekanik yönden düzeltici rol oynadığı ortaya koyulmuştur. Anahtar kelimeler: Pistacia atlantica, yara iyileşmesi, histopatoloji, biomekanik, deri Objectives: This study has been undertaken to investigate the antioxidant activity of the gel formulation from Pistacia atlantica oil extraction on enzymatic antioxidants in experimental wound created in rats. Materials and Methods: Under anesthesia, a square-shaped skin defect (2x2 cm) was created aseptically by surgical incision. Then, animals were randomly allocated to four groups (I-untreated controls, II-topically treated with base gel, III-topically treated with 5% gel, IV-topically treated with 10% gel). Results:The results suggest that topical application of Pistacia atlantica oil gels improved reepithelialization with continuous stratum basalis and a mature granulation tissue and adnexa (hair follicles and sweat gland) compared with control and base gel groups. Treatment with 10% oil gel significantly enhanced the tensile strength, ultimate stress, yield strength and stiffness in this group compared with the control and base gel groups at 21 days post injury. The collagen fibers showed a more organized pattern and the tissue alignment was greater as compared to the control and base gel-treated groups at the same stage. Conclusion:The results suggest that topical application of Pistacia atlantica oil gel improved the morphological, biochemical and biomechanical properties of experimentally-induced wound defects in rats.

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Oleic acid modulation of the immune response in wound healing: A new approach for skin repair

Cited by 126 publications

References 41 publications

Excess Linoleic Acid Increases Collagen I/III Ratio and “Stiffens” the Heart Muscle Following High Fat Diets

Excess Linoleic Acid Increases Collagen I/III Ratio and “Stiffens” the Heart Muscle Following High Fat Diets

Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

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