Oleic acid prevents erythrocyte death by preserving haemoglobin and erythrocyte membrane proteins

Banerjee, Adrita; Dey, Tiyasa; Majumder, Romit; Bhattacharya, Tuhin; Dey, Sanjit; Bandyopadhyay, Debasish; Chattopadhyay, Aindrila

doi:10.1016/j.freeradbiomed.2023.03.019

Cited by 5 publications

(1 citation statement)

References 68 publications

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“…Contrarily, some studies have also suggested that both oleic and linoleic acids can cause cytotoxicity depending on the concentration and period of exposure, which has not been established yet [ 38 ]. Moreover, linoleic acid is also known to be highly vulnerable to oxidative stress, leading to cell damage [ 39 ]. In this study, we found that CP causes oxidative stress, which might affect the stability of linoleic acid.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats

Tripathy,

Raghavendra,

Dutta

et al. 2023

Vet World

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Background and Aim: Cisplatin (CP) is a preferred drug for cancer treatment but it has dose-dependent side effects. Vitex agnus-castus (VAC) berry extract has antioxidant, free-radical scavenging, and anti-inflammatory activities. This study explored the mitigating effects of VAC extract (VACE) on acute hematotoxicity induced by CP in female Wistar rats. Materials and Methods: Female Wistar rats (n = 30) were randomly divided into five groups (n = 6/group). The normal control (NC) group received no treatment. The CP control group received CP (7 mg/kg.b.w. ip, single dose) and the drug control group (VACE-650) received VACE (650 mg/kg b.w. oral, daily) for 7 days. Both groups received a single dose of CP (7 mg/kg b.w. ip), followed by 350 and 650 mg/kg.b.w. of VACE daily orally (CPVACE-350 and CPVACE-650 groups, respectively) for 7 days. Results: After a single dose of CP (7 mg/kg b.w.), the red blood cells (RBC), hematocrit (HCT), white blood cells (WBC), and platelets significantly decreased. In the VAC-350 group, the reduction in total WBC count was less than that in the VAC-650 group on the 3rd day. The RBC and HCT values of the VACE groups were better than that of the CP control, but the VACE-350 treatment group showed significant improvement only on the 3rd day. Conclusion: Our findings showed that VACE can mitigate CP-induced damage to peripheral blood cells at lower doses. Keywords: cisplatin, hematotoxicity, rats, Vitex agnus-castus.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats

Tripathy,

Raghavendra,

Dutta

et al. 2023

Vet World

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A novel blood spot with oil sealing for antioxidation and completeness preservation of erythrocytes and hemoglobin

Zha,

Xiao,

Tian

et al. 2025

Analytica Chimica Acta

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Regulation of N⁶‐methyladenosine modification in erythropoiesis and thalassemia

Zheng,

Lin,

Chen

et al. 2024

Clinical Genetics

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In eukaryotic RNA, N6‐methyladenosine (m6A) is a prevalent form of methylation modification. The m6A modification process is reversible and dynamic, written by m6A methyltransferase complex, erased by m6A demethylase, and recognized by m6A binding proteins. Through mediating RNA stability, decay, alternative splicing, and translation processes, m6A modification regulates gene expression at the post‐transcriptional level. Erythropoiesis is the process of hematopoietic stem cells undergoing proliferation, a series of differentiation and maturation to form red blood cells (RBCs). Thalassemia is a common monogenic disease characterized by excessive production of ineffective RBCs in the peripheral circulation, resulting in hemolytic anemia. Increasing evidence suggests that m6A modification plays a crucial role in erythropoiesis. In this review, we comprehensively summarize the function of m6A modification in erythropoiesis and further generalize the mechanism of m6A modification regulating ineffective erythropoiesis and fetal hemoglobin expression. The purpose is to improve the understanding of the pathogenesis of erythroid dysplasia and offer new perspectives for the diagnosis and treatment of thalassemia.

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Oleic acid prevents erythrocyte death by preserving haemoglobin and erythrocyte membrane proteins

Cited by 5 publications

References 68 publications

Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats

Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats

A novel blood spot with oil sealing for antioxidation and completeness preservation of erythrocytes and hemoglobin

Regulation of N⁶‐methyladenosine modification in erythropoiesis and thalassemia

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Oleic acid prevents erythrocyte death by preserving haemoglobin and erythrocyte membrane proteins

Cited by 5 publications

References 68 publications

Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats

Evaluation of the therapeutic efficacy of Vitex agnus-castus extract on cisplatin-induced hematotoxicity in female Wistar rats

A novel blood spot with oil sealing for antioxidation and completeness preservation of erythrocytes and hemoglobin

Regulation of N6‐methyladenosine modification in erythropoiesis and thalassemia

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Regulation of N⁶‐methyladenosine modification in erythropoiesis and thalassemia