2019
DOI: 10.1016/j.bbamcr.2018.10.010
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(−)‑Oleocanthal inhibits proliferation and migration by modulating Ca2+ entry through TRPC6 in breast cancer cells

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Cited by 49 publications
(43 citation statements)
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“…We have recently reported that TRPC6 modulates the plasma membrane expression of Orai1 and Orai3 channels in triple negative and luminal, respectively, breast cancer cells. Thus, attenuation of the expression of TRPC6, either by using interference RNA or by cell treatment with the phenolic compound oleocanthal, results in a significant decrease in SOCE in these cells [100,101]. TRPC6-dependent plasma membrane recycling of Orai1 is entirely dependent on Ca 2+ and Na + influx through TRPC6 channels as it is abolished by expression of the pore-dead dominant-negative TRPC6 mutant [100] (Figure 3c).…”
Section: Modulation Of Orai1 Function By Trpc Channelsmentioning
confidence: 96%
“…We have recently reported that TRPC6 modulates the plasma membrane expression of Orai1 and Orai3 channels in triple negative and luminal, respectively, breast cancer cells. Thus, attenuation of the expression of TRPC6, either by using interference RNA or by cell treatment with the phenolic compound oleocanthal, results in a significant decrease in SOCE in these cells [100,101]. TRPC6-dependent plasma membrane recycling of Orai1 is entirely dependent on Ca 2+ and Na + influx through TRPC6 channels as it is abolished by expression of the pore-dead dominant-negative TRPC6 mutant [100] (Figure 3c).…”
Section: Modulation Of Orai1 Function By Trpc Channelsmentioning
confidence: 96%
“…Interestingly, knock-down of TRPC6 not only attenuated invasion, but also decreased the expression of the adhesion protein fibronectin and the tight junction protein ZO-1 [110]. Furthermore, TRPC6 was of importance in regulating breast cancer MDA-MB-231 cell migration [111]. TRPC6 expression has been found upregulated in breast cancer cell lines, MCF-7 and MDA-MB-231, compared with normal breast epithelial MCF10A cells.…”
Section: Trpc Channels Migration and Invasionmentioning
confidence: 99%
“…OLE with the dual HER2/EGFR inhibitor, LP, induced synergistic tumor growth inhibition [115] MCF-10A, MDA-MB-231, and MCF-7 1, 10, and 20 µM OLE could be responsible for the selective activation of TRCP6-dependent Ca 2+ influx and TRCP6 down-regulation at low µM concentrations [116] Huh-7, HepG2, and HCCLM3 HCC cancer cell lines [0-80 µM]…”
Section: Olive Tree Secoiridoids and Cancermentioning
confidence: 99%