Oleuropein

Abstract

Oleuropein, a novel immunomodulator derived from olive tree, was assessed in vitro and in experimental sepsis by Pseudomonas aeruginosa. After addition in monocyte and neutrophil cultures, malondialdehyde, TNF-alpha, IL-6, and bacterial counts were estimated in supernatants. Acute pyelonephritis was induced in 70 rabbits after inoculation of pathogen in the renal pelvis. Intravenous therapy was administered in four groups postchallenge by one multidrug-resistant isolate (A, controls; B, oleuropein; C, amikacin; D, both agents) and in three groups postchallenge by one susceptible isolate (E, controls; F, oleuropein; G, amikacin). Survival was recorded; bacterial growth in blood and organs was counted; endotoxins (LPS), malondialdehyde, total antioxidant status, and TNF-alpha in serum were estimated. TNF-alpha and IL-6 of cell supernatants were not increased compared with controls when triggered by LPS and P. aeruginosa. Counts of multidrug-resistant P. aeruginosa were decreased in monocyte supernatants. Median survival of groups A, B, C, D, E, F, and G were 3.00, 6.00, 2.00, 10.00, 1.00, 5.00, and 1.00 days, respectively. Bacteria in blood were lower at 48 h in groups B and D compared with A and in groups F and G compared with E. Total antioxidant status decreased steadily over time in groups A, C, D, and G, but not in groups B and F. TNF-alpha of groups B, C, and D was lower than A at 48 h. Tissue bacteria decreased in group F compared with E. Oleuropein prolonged survival in experimental sepsis probably by promoting phagocytosis or inhibiting biosynthesis of proinflammatory cytokines.

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

“…In this context, many scientists have focused their attention on the possibility of using individual EVOO polyphenolic compounds like oleuropein, as a promising alternative anti-inflammatory agent, due to its capability to inhibit the synthesis of pro-inflammatory cytokines [58,59] and lipoxygenase activity [4], or to modulate inflammatory parameters [60].…”

Effects of the Olive-Derived Polyphenol Oleuropein on Human Health

“…Some studies documented that oleuropein elicits anti-inflammatory effects by lipoxygenase activity, production of leukotriene B4 [38], inhibiting biosynthesis of pro-inflammatory cytokines [39] or modulating inflammatory parameters [40]. In particular, Impellizzeri et al [40] reported that administration of oleuropein in a mouse model of carrageenan-induced pleurisy causes a significant reduction of tumor necrosis factor α (TNF-α), interleukin-1 beta (IL-1β) and nitric oxide (NO).…”

Quality characteristic and antioxidant activity of yogurt containing olive leaf hot water extract

“…Oleuropein is the most abundant biophenol and is the major bioactive compound found in olive leaves (Aouidi et al, 2012). In many in vivo and in vitro studies, oleuropein showed various biologic activities including antibacterial, antioxidant, anti-ischemic, antihypertensive, anticoagulant, hypolipidemic, and anticancer activities (AlShaal, Karabet, & Daghestani., 2019;Andreadou et al, 2006;Giamarellos-Bourboulis et al, 2006;Hamdi & Castellon, 2005;Himour, Yahia, & Belattar, 2017;Romero et al, 2016).…”