Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow

Santiago-Mora, Raquel; Casado-Díaz, Antonio; Castro, M D de; Quesada‐Gómez, José Manuel

doi:10.1007/s00198-010-1270-x

Cited by 134 publications

(94 citation statements)

References 38 publications

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“…An experimental model showed that bone remodeling was more pronounced in laboratory animals which had been treated with a paly phenol diet [7]. A possible influence of olive oil on bone mass inteance and osteoporosis prevention, its results showed that women on a Mediterranean diet rich in olive oil had better bone density levels than those on a standard diet [32].…”

Section: Discussionmentioning

confidence: 99%

“…Increase cancer, stroke and coronary heart disease risks associated with long term use of postmenopausal hormone therapy (HT) have rapidly declined the number of women treated with HT either estrogen alone or estrogen plus progesterone [6]. An experimental model showed that bone remodeling was more pronounced in laboratory animals which had been treated with a polyphenols-rich diet [7]. According, [8] reported that the high quality of olive oil reduces low density lipoprotein cholesterol (LDL), peroxidation to significant higher extent than sunflower oil in hypercholesterolemia postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

Salem¹

2015

IJNFS

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Abstract:This study aimed to evaluate the effect of feeding on virgin olive oil (VOO) and extra virgin olive oil (EVOO) at 50% and 100% with or without thyme leaves at 1% and 2.5% on pregnancy and lactation periods. Methods: One hundred and twenty adult female rats (120 ±5g) were randomly divided into 15 groups (n=8) for month before mating. On 19 th day of pregnancy, half of pregnant rats were weighted, killed and their fetuses take off with uterus. Another half of pregnant rats were left to evaluate the lactation period. Biochemical assays, bone measurements and fertility hormones were evaluated. Results: Generally, the VOO groups were improved the health status of pregnant and lactating rats more than EVOO groups. The pregnant rats in VOO and thyme leaves powder groups were lower of body weight gain (BWG) without their fetuses than EVOO and thyme leaves powder groups. The mean weight of fetuses in VOO and thyme leaves powder groups were higher than EVOO combined with thyme leaves groups. Also, the feeding on olive oils with thyme leaves had an increase of number of fetuses and bone Ca and P contents. The results showed that, in an increasing of number of fetuses caused decrease in bone mineral density (BMD). Pregnant and lactating rats fed on 100% olive oils had TC, TG, LDL-C, and VLDL-C lower than the rats fed on 50% olive oils. Also, the rats fed on olive oils and thyme leaves powder had increase in both E2 and progesterone levels before mating and at the end of lactation period compared to control group. Meanwhile, the prolactin hormone levels for rats at the end of lactation period were lower than on 19 th day of pregnancy period. Conclusion: Diet which containing with olive oil improved the health status, especially during pregnancy and lactation periods. Consumption of olive oil and olive oil and thyme leaves could be reduce the risk of infertility in females.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

Salem¹

2015

IJNFS

View full text Add to dashboard Cite

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“…Some epidemiological studies showed correlation between olive products consumption and incidence of breast cancer. Due to its little mild side effects, oleuropein is required as one of the phenolic compounds in olive with a powerful effect on inhibiting the proliferation and migration of cancer cells (Sirianni et al, 2010;Santiago-Mora et al, 2011). Oleuropein can also target steps in cancer progression (Abe et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells

Hassan¹,

Elamin²,

Omer³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Purified oleuropein considerably reduced the infarct size in both normal and hypercholesterolemic rabbits that were subjected to ischemia/reperfusion, protected the reperfused myocardium from the oxidative damage and decreased total cholesterol and triglyceride levels (Andreadou et al 2006). In vitro, oleuropein reduced the expression of PPARc, inhibited adipogenesis and enhanced osteoblastogenesis in stem cells derived from human bone marrow (Santiago-Mora et al 2011). Oleuropein (in concentration higher than 100 lM) acted on 3T3-L1 cells to reduce preadipocyte differentiation and lipid accumulation and thus regulated the size of fat cells.…”

Section: Introductionmentioning

confidence: 99%

Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma

et al. 2013

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Oleuropein, the major phenolic compound found in olive leaves and oil, exerts antioxidant, antiinflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Herein, we characterized molecular mechanisms underlying the anti-adipogenic effects of oleuropein on 3T3-L1 cells and adipocytes derived from stromal-vascular fraction of dorsolumbar and gonadal fat dissected from mice. We found that oleuropein ([100 lM) decreased viability of preadipocytes proliferating in vitro and did not exerted any cytotoxic effects in post-confluent cells after induction of differentiation.

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Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow

Abstract: Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis.

Cited by 134 publications

References 38 publications

Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells

Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma

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