Oleuropein evaluated in vitro and in vivo as an antioxidant

Speroni, Ester; Guerra, Maurizio; Minghetti, Andrea; Crespi‐Perellino, N.; Pasini, Patrizia; Piazza, Francesco; Roda, Aldo

doi:10.1002/(sici)1099-1573(1998)12:1+<s98::aid-ptr263>3.0.co;2-m

Cited by 47 publications

(20 citation statements)

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“…1). It exhibited high antioxidant activity in vitro, comparable to a hydrosoluble analog of tocopherol 31 and exhibited strong antioxidant protection in oxidative stress during ischemia-reperfusion in an in vivo experimental model. The major constituent of the OLE was oleuropein (Fig.…”

Section: Group Of Active Constituentsmentioning

confidence: 97%

Phytochemical analysis and gastroprotective activity of an olive leaf extract

Dekanski¹,

Janićijević-Hudomal

Tadić

et al. 2009

JSCS

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Some medicinal features of olive leaf have been known for centuries. It has been traditionally used as an antimicrobial and to prevent and treat diabetes mellitus and heart disease. Whether olive leaf, a natural antioxidant, influences the gastric defense mechanism and exhibits gastroprotection against experimentally-induced gastric lesions remains unknown. In this study, the content of total phenols, total flavonoids and tannins in olive leaf extract (OLE) were determined. Seven phenolic compounds were identified and quantified (oleuropein, caffeic acid, luteolin, luteolin-7-O-glucoside, apigenin-7-O-glucoside, quercetin, and chryseriol). Furthermore, the protective activity of the OLE in gastric mucosal injury induced by a corrosive concentration of ethanol was investigated. In relation to the control group, pretreatment with OLE (40, 80 and 120 mg kg -1 ) significantly (p < 0.001) attenuated the gastric lesions induced by absolute ethanol. The protective effect of the OLE was similar to that obtained with a reference drug, ranitidine. The results obtained indicate that OLE possesses significant gastroprotective activity, and that the presence of compounds with antioxidative properties would probably explain this effect.

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Section: Group Of Active Constituentsmentioning

confidence: 97%

Phytochemical analysis and gastroprotective activity of an olive leaf extract

Dekanski¹,

Janićijević-Hudomal

Tadić

et al. 2009

JSCS

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“…Oleuropein is the main constituent of olive leaf, which thought to be responsible for its pharmacological effects. It has remarkable antioxidant activity in vitro (Speroni et al ., ), as do other constituents of olive leaf (Briante et al ., ). In vitro , oleuropein and its major metabolite, hydroxytyrosol, exhibited a range of pharmacological properties, antiinflammatory effects (Miles et al ., ), scavenging of free radicals in addition to inhibition of 5‐lipoxygenase and 12‐lipoxygenase (Visioli et al ., ).…”

Section: Introductionmentioning

confidence: 98%

Protective Effect of Hydroalcoholic Olive Leaf Extract on Experimental Model of Colitis in Rat: Involvement of Nitrergic and Opioidergic Systems

Fakhraei

Abdolghaffari

Delfan

et al. 2014

Phytotherapy Research

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The aim of the present study is to investigate the possible protective effect of dry olive leaf extract (OLE) against acetic acid-induced ulcerative colitis in rats, as well as the probable modulatory effect of nitrergic and opioidergic systems on this protective impact. Olive leaf extract was administered (250, 500 and 750 mg/kg) orally for two successive days, starting from the colitis induction. To assess the involvement of nitrergic and opioidergic systems in the possible protective effect of OLE, L-NG-Nitroarginine Methyl Ester (10 mg/kg) and naltrexone (5 mg/kg) intraperitoneal (i.p.) were applied 30 min before administration of the extract for two successive days, respectively. Colonic status was investigated 48 h following induction through macroscopic, histological and biochemical analyses. Olive leaf extract dose-dependently attenuated acetic acid-provoked chronic intestinal inflammation. The extract significantly reduces the severity of the ulcerative lesions and ameliorated macroscopic and microscopic scores. These observations were accompanied by a significant reduction in the elevated amounts of TNF-α and interlukin-2 markers. Moreover, both systems blockage reversed protective effects of OLE in the rat inflammatory bowel disease model. These finding demonstrated, for the first time, a possible role for nitrergic and opioidergic systems in the aforementioned protective effect, and the extract probably exerted its impact increasing nitric oxide and opioid tones.

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“…Diets rich in olive oil reduce tissue oxidative stress and enhance the glutathione antioxidant defense system in atherosclerotic rabbits (39), thus diets rich in polyphenols are currently recommended for the prevention of atherosclerosis (40,41). Oleuropein has high antioxidant activity in vitro, comparable to a water soluble analog of tocopherol (42). Oleuropein also scavenges superoxide anions and hydroxyl radicals, and inhibits the respiratory burst of neutrophils and hypochlorous acid derived radicals.…”

Section: Oleuropeinmentioning

confidence: 99%

Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

et al. 2013

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-Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C. One of the major problems with herbal drugs is that the active ingredients are not well defined. It is important to know the active components and their molecular interactions which will help to analyze their therapeutic efficacy and also to standardize the product. There are a number of medicinal plants known for their anti-diabetic effect that possess similarities in their active chemical components, e.g. iridoid and secoiridoid glycosides. Methods. In this study, we have compared the structure of various iridoid and secoiridoid glycosides to design a novel pharmacophore. We further developed a structure-activity relationship for the inhibition of glycogen phosphorylase-a. Conclusion. By using docking studies, we are proposing, for the first time, that inhibition of glycogen phosphorylase-a activity is a common target for iridoids and secoiridoids to elicit anti-diabetic effects.

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Oleuropein evaluated in vitro and in vivo as an antioxidant

Cited by 47 publications

References 0 publications

Phytochemical analysis and gastroprotective activity of an olive leaf extract

Phytochemical analysis and gastroprotective activity of an olive leaf extract

Protective Effect of Hydroalcoholic Olive Leaf Extract on Experimental Model of Colitis in Rat: Involvement of Nitrergic and Opioidergic Systems

Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

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