Oleuropein induces apoptosis via abrogating NF‐κB activation cascade in estrogen receptor–negative breast cancer cells

Liu, Lian; Ahn, Kwang Seok; Shanmugam, Muthu K.; Wang, Hong; Shen, Hongyuan; Arfuso, Frank; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Chang, Yung Sheng; Sethi, Gautam; Tang, Feng Ru

doi:10.1002/jcb.27738

Cited by 100 publications

(76 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elamin et al [136] was able to extend the use of Ole to the less responsive basal-like breast cancer cells (MDA-MB-231 cells), and demonstrated its ability to abrogate NF-kB expression, a well-known transcription factor involved in the control of many genes driving cancer development and progression, e.g., inflammation, immune reaction, proliferation, and apoptosis. This last finding was also confirmed by Liu et al [137].…”

Section: Pro-apoptotic and Anti-proliferative Effects Of Oleuropeinsupporting

confidence: 82%

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

et al. 2019

View full text Add to dashboard Cite

Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.

show abstract

Section: Pro-apoptotic and Anti-proliferative Effects Of Oleuropeinsupporting

confidence: 82%

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It provided a comprehensive insight to explain the different response of MCF-7 and MDA-MB-231 cells to the β-estradiol stimulation. Meanwhile, given the MDA-MB-231 is triple negative breast cancer cell without oestrogen receptors [47,48], the results also confirmed that the membrane phase and lipid diffusion were not affected by β-estradiol in MDA-MB-231 cells, indicating that the slow subdiffusion of CT-B could be used to assess the response of lipid raft-related receptors in specific pathophysiological processes. And the increased area of Lo phase was near to that of laser focal volume, resulting in the increased proportion of slow subdiffusion.…”

Section: Discussionmentioning

confidence: 67%

“…The slow subdiffusion component (ie, t > 100 ms, D < 0.2 μm 2 s −1 ) remained undetected. The underlying reason for this difference compared with MCF-7 cells was that MDA-MB-231 cells were triple negative breast cancer cells without oestrogen receptors, which resulted in less response to the stimulation of β-estradiol [47,48]. The histogram of CT-B diffusion time showed that the diffusion time was significantly increased above 100 ms, and the related diffusion (Figure 5B,F).…”

Section: The Effect Of β-Estradiol On the Membrane Rafts In Mcf-7 Cmentioning

confidence: 99%

Self‐assembly of lipid rafts revealed by fluorescence correlation spectroscopy in living breast cancer cells

Dong

Tang

Wang

et al. 2019

Journal of Biophotonics

View full text Add to dashboard Cite

Lipids and proteins in the plasma membrane are laterally heterogeneous and formalised as lipid rafts featuring unique biophysical properties. However, the self-assembly mechanism of lipid raft cannot be revealed even its physical properties and components were determined in specific physiological processes. In this study, two-photon generalised polarisation imaging and fluorescence correlation spectroscopy were used to study the fusion of lipid rafts through the membrane phase and the lateral diffusion of lipids in living breast cancer cells. A self-assembly model of lipid rafts associated with lipid diffusion and membrane phase was proposed to demonstrate the lipid sorting ability of lipid rafts in the plasma membrane. The results showed that the increased proportion of slow subdiffusion of G M1binding cholera toxin B-subunit (CT-B) was accompanied with an increased liquid-ordered domain during the β-estradiol-induced fusion of lipid rafts. And slow subdiffusion of CT-B was vanished with the depletion of lipid rafts.Whereas the dialkylindocarbocyanine (DiIC 18 ) diffusion was not specifically regulated by lipid rafts. This study will open up a new insight for uncovering the self-assembly of lipid rafts in specific pathophysiological processes. K E Y W O R D Sanomalous diffusion, fluorescence correlation spectroscopy, lipid rafts, membrane phase, selfassembly

show abstract

“…TIPE2 is found to be involved in the positive regulation of tobacco-promoted lung carcinogenesis by modulating the expression of NF-κB and NF-κB-regulated gene products, such as Cox-2, survivin, Cyclin D1, MMP-9, and CXCR-4. NF-κB is a transcription factor that regulates the expression of genes involved in lung carcinogenesis [73][74][75][76][77][78][79][80][81][82][83]. Alvira and their group reported high levels of nuclear NF-κB in lung cancer tissues and enhanced NF-κB activity well-correlated with more advanced disease in lung adenocarcinoma [84].…”

Section: Discussionmentioning

confidence: 99%

TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade

et al. 2019

Self Cite

View full text Add to dashboard Cite

Lung cancer represents the most common cause of cancer deaths in the world, constituting around 11.6% of all new cancer cases and 18.4% of cancer-related deaths. The propensity for early spread, lack of suitable biomarkers for early diagnosis, as well as prognosis and ineffective existing therapies, contribute to the poor survival rate of lung cancer. Therefore, there is an urgent need to develop novel biomarkers for early diagnosis and prognosis which in turn can facilitate newer therapeutic avenues for the management of this aggressive neoplasm. TIPE2 (tumor necrosis factor-α-induced protein 8-like 2), a recently identified cytoplasmic protein, possesses enormous potential in this regard. Immunohistochemical analysis showed that TIPE2 was significantly upregulated in different stages and grades of lung cancer tissues compared to normal lung tissues, implying its involvement in the positive regulation of lung cancer. Further, knockout of TIPE2 resulted in significantly reduced proliferation, survival, and migration of human lung cancer cells through modulation of the Akt/mTOR/NF-κB signaling axis. In addition, knockout of TIPE2 also caused arrest in the S phase of the cell cycle of lung cancer cells. As tobacco is the most predominant risk factor for lung cancer, we therefore evaluated the effect of TIPE2 in tobacco-mediated lung carcinogenesis as well. Our results showed that TIPE2 was involved in nicotine-, nicotine-derived nitrosamine ketone (NNK)-, N-nitrosonornicotine (NNN)-, and benzo[a]pyrene (BaP)-mediated lung cancer through inhibited proliferation, survival, and migration via modulation of nuclear factor kappa B (NF-κB)- and NF-κB-regulated gene products, which are involved in the regulation of diverse processes in lung cancer cells. Taken together, TIPE2 possesses an important role in the development and progression of lung cancer, particularly in tobacco-promoted lung cancer, and hence, specific targeting of it holds an enormous prospect in newer therapeutic interventions in lung cancer. However, these findings need to be validated in the in vivo and clinical settings to fully establish the diagnostic and prognostic importance of TIPE2 against lung cancer.

show abstract

Oleuropein induces apoptosis via abrogating NF‐κB activation cascade in estrogen receptor–negative breast cancer cells

Cited by 100 publications

References 84 publications

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Self‐assembly of lipid rafts revealed by fluorescence correlation spectroscopy in living breast cancer cells

TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade

Contact Info

Product

Resources

About