Oleuropein inhibits tumour growth and metastases dissemination in ovariectomised nude mice with MCF-7 human breast tumour xenografts

Nutrigenomics of extra‐virgin olive oil: A review

“…In animal models oleuropein has been described to prevent the colitis‐associated molecular changes characteristic of an increased risk of developing colorectal cancer . Recent studies in a MCF‐7 breast carcinoma xenograft generated in ovariectomised nude mice, demonstrated that an oleuropein‐enriched diet significantly decreases the tumour growth rate and prevents the formation of both peripulmonary and parenchymal lung metastases . This earliest in vivo evidence on the chemopreventive activity of this VOO compound in breast cancer is worth of further clinical investigation.…”

Anticancer effects of oleuropein

“…A limited number of studies have examined the effects of oleuropein administration on tumor growth in animals in vivo (Table ). Administration of oleuropein (125 mg/kg b.w) to ovariectomised nude mice xenografted with MCF‐7 human breast cancer cells resulted in inhibition of xenograft tumor growth and metastases and efficiently prevented both the mouse body weight loss and the peripulmonary dissemination of tumor masses (Table ). In contrast to the above studies, administration of oleuropein (0.3 mg/kg b.w) to male adult Wistar rats xenografted with C6 glioma cells did not result in inhibition of xenograft tumor growth (Table ).…”

Evaluation of phenolics and acrylamide and their bioavailability in high hydrostatic pressure treated and fried table olives

“…The most important table olive variety elaborated according to the Spanish‐style process is “Hojiblanca” which is produced in Andalucía, currently followed by “Manzanilla Sevillana” and “Manzanilla Cacereña.” Table olives contain a characteristic profile of phenolics. These antioxidant compounds (Kountouri, Mylona, Kaliora, & Andrikopoulos, ; Malheiro, Mendes, Fernandes, & Rodrigues, ) may contribute to health benefits due to the protective effects exerted against coronary heart diseases (Zbakh & El Abbasi, ) and against some types of cancer (Sepporta et al, ).…”