Olfaction: A potential cognitive marker of psychiatric disorders

Atanasova, Boriana; Graux, Jérôme; El‐Hage, Wissam; Hommet, Caroline; Camus, Vincent; Belzung, Catherine

doi:10.1016/j.neubiorev.2008.05.003

Cited by 210 publications

(166 citation statements)

References 141 publications

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“…Deficits in odor discrimination in schizophrenia have, by now, also become well documented. 50,51 Although early literature on olfactory deficits tended to focus on issues such as hedonics and potential limbic involvement, subsequent studies demonstrated severe impairments even at the level of identification and discrimination. NMDA receptors are known to play a critical role in olfactory processing, particularly in processes such as discrimination and habituation.…”

Section: Other Sensory Systemsmentioning

confidence: 99%

Sensory Processing in Schizophrenia: Neither Simple nor Intact

Javitt

2009

Schizophrenia Bulletin

280

186

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This special issue focuses on the theme of sensory processing dysfunction in schizophrenia. For more than 50 years, from approximately the time of Bleuler until the early 1960s, sensory function was considered one of the few preserved functions in schizophrenia (Javitt 1 ). Fortunately, the last several decades have brought a renewed and accelerating interest in this topic. The articles included in the issue range from those addressing fundamental bases of sensory dysfunction (Brenner, Yoon, and Turetsky) to those that examine how elementary deficits in sensory processing affect the sensory experience of individuals with schizophrenia (Butler, Kantrowitz, and Coleman) to the question of how sensory-based treatments may lead to improvement in remediation strategies (Adcock). Although addressing only a small portion of the current complex and burgeoning literature on sensory impairments across modalities, the present articles provide a cross-section of the issues currently under investigation. These studies also underscore the severe challenges that individuals with schizophrenia face when trying to decode the complex world around them.

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Section: Other Sensory Systemsmentioning

confidence: 99%

Sensory Processing in Schizophrenia: Neither Simple nor Intact

Javitt

2009

Schizophrenia Bulletin

280

186

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“…These new generation of portable olfactometers, will certainly allow a large number of applications, comprising those related to enhancing the sense of presence in virtual reality environments. These devices will also contribute to investigating perceptual, emotional, and retention-related (memory) aspects of olfaction in humans, as well as be part of multisensory rehabilitations techniques for a number of neuropsychological disorders (Atanasova et al, 2008;Baba et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Development and Testing of a Small-Size Olfactometer for the Perception of Food and Beverages in Humans

Risso

Covarrubias

Bordegoni

et al. 2018

Front. Digit. Humanit.

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Studies of olfactory perception and about the way humans interact with, and perceive food and beverages require appropriate olfactory devices. Moreover, small size, and portable interfaces are needed within the context of Human Computer Interaction (HCI), to enrich and complete the design of different mediated experiences. In this paper, the authors tested a new portable olfactory device for the orthonasal administration of smells. The main aim was to verify if the experience generated by the odors delivered through such device can affect people's taste perception. Once established that people could perceive odors using the olfactory device, a group of participants was asked to taste two different types of food (Experiment 1) and three types of beverages (Experiment 2) and to evaluate them on a number of perceptual-dimensions (such as pleasantness, freshness, sweetness, saltiness, and bitterness). The participants could taste the food and the beverage without the presence of additional olfactory stimuli, or under conditions where olfactory stimuli (the smell of chocolate or citrus) were also presented using the device. The results showed that the participants' evaluation of food and beverages was significantly modulated by the concurrently presented odors. The experimental results suggest that: (1) the device is effective in controlling the delivery of odors to human participants without the complexity of management that often affect larger odors delivery systems; (2) odors administered by means of such device can have an effects on food and beverage perception, without the need to change their chemical properties.

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“…23,[33][34][35] Some investigators theorize that olfactory declines may be a consequence of autoimmune mechanisms 36 or neurodegenerative diseases. 37 The prognosis of olfactory dysfunction is influenced by certain demographic and clinical factors. Over time, regaining the sense of smell is more likely in females, 38 younger persons, 38,39 those with lesser severity of initial olfactory loss, 39 and those with shorter duration of dysfunction.…”

Section: Discussionmentioning

confidence: 99%

A possible correlation between vitamin D deficiency and loss of smell: 2 case reports

Kruse¹,

Cambron

2011

Journal of Chiropractic Medicine

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Objective: The purpose of this report is to present 2 cases of diminished olfaction that improved with increasing serum levels of vitamin D3. Clinical Features: Both patients were under the care of medical and chiropractic physicians for various complaints. A 47-year-old hyposmic woman was diagnosed with vitamin D deficiency who incidentally noticed a progressive return of her sense of smell while taking vitamin D supplements as prescribed by her medical doctor. A 34-year-old anosmic woman noticed a direct relationship with her ability to smell and vitamin D3 supplementation. Intervention and Outcome: Treatment for the first patient consisted of vitamin D supplementation of 10 000 IU a day. Her serum D3 levels increased substantially over a period of 8 months, at which time she reported a marked improvement in her sense of smell. The second patient was prescribed 50 000 IU of vitamin D a week; and she reported an increased ability to smell, although only the strongest of odors. Conclusion: A link between hypovitaminosis D and a diminished sense of smell was noted in these 2 individuals.

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Olfaction: A potential cognitive marker of psychiatric disorders

Cited by 210 publications

References 141 publications

Sensory Processing in Schizophrenia: Neither Simple nor Intact

Sensory Processing in Schizophrenia: Neither Simple nor Intact

Development and Testing of a Small-Size Olfactometer for the Perception of Food and Beverages in Humans

A possible correlation between vitamin D deficiency and loss of smell: 2 case reports

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