Olfaction in vector-host interactions

Takken, Willem; Knols, Bart G. J.

doi:10.3920/978-90-8686-698-4

Cited by 40 publications

(20 citation statements)

References 662 publications

(1,165 reference statements)

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“…It is often reported that when exposed to a group of hosts (of the same species), mosquitoes seeking hosts express a preference for one individual over others (Knols et al, 1995;Qiu et al, 2006;Takken & Knols, 2018). This preference is probably caused by the natural variation in odorants between individuals, which affects insects even at very low concentrations, and demonstrates the high sensitivity of odorant receptors to semiochemicals (Reisenman et al, 2016;Zwiebel & Takken ,2004).…”

Section: Discussionmentioning

confidence: 99%

Genetic variation in the odorant receptor gene OR4 and bit habits in natural populations of Aedes aegypti from Antioquia department, Colombia

2019

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It has been determined factors that make humans more attractive to mosquitoes and which strategies they use to detect a potential host. Preferential differences for human/non-human hosts are related to variations in odorant receptors (OR) genes in the Aedes aegypti mosquitoes. This study use sequencing to establish the genetic variation in the odor receptor OR4 in 900 mosquitoes from different regions of Antioquia. A behavioral test using an olfactometer was also made to stablish the relationship of these variation with the attraction on different human hosts. The analysis in the attraction and OR4 variants did not show significant differences in the arrival rate among different human hosts. No significant differences in the description of OR4 variants between populations and between hosts, show that this gene is homogeneously distributed. The analysis showed a high genetic population diversity, measured as polymorphism and heterozygosity. This may be due to a few high frequency haplotypes in all the populations examined, suggesting a model of high gene flow between populations and/or selection in favor of these variants in all populations. Other lowfrequency variants, many of which are population-specific, reflect the effect of genetic drift probably due to stochastic changes in the size of natural mosquito populations.

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Section: Discussionmentioning

confidence: 99%

Genetic variation in the odorant receptor gene OR4 and bit habits in natural populations of Aedes aegypti from Antioquia department, Colombia

2019

Preprint

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“…Mosquitoes are able to detect and discriminate thousands of odor molecules, which may further vary depending on the host preference. These complex behavioral events are largely mediated by the diverse chemosensory genes encoding odorant binding proteins (OBPs), odorant degrading enzymes (ODEs), odorant receptors (ORs) and other accessory proteins including sensory neuron membrane protein (SNMP) (10). Odorant binding proteins (OBPs), which are bathed within the sensillum lymph, are low molecular weight soluble proteins that mediate the first interaction of the olfactory system with the external world (10), (11), (12).…”

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confidence: 99%

“…These globular protein molecules showed significant diversity within the same family and are believed to bind with a wide range of hydrophobic odorant molecule. After binding with these odor molecules, OBPs shuttle it to their respective olfactory receptors present on olfactory receptor neurons (ORNs) (13), (10), (14). Insect olfactory receptors (OrX) are present to work in association with the obligate receptor co-receptor (Orco) on the dendritic membrane of ORN (10).…”

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confidence: 99%

“…After binding with these odor molecules, OBPs shuttle it to their respective olfactory receptors present on olfactory receptor neurons (ORNs) (13), (10), (14). Insect olfactory receptors (OrX) are present to work in association with the obligate receptor co-receptor (Orco) on the dendritic membrane of ORN (10). Orco is essential for proper dendritic trafficking of the OrX, facilitating the formation of odorant gated ion channels by structural alteration that is opened upon odorant binding (10), (15).…”

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confidence: 99%

“…Insect olfactory receptors (OrX) are present to work in association with the obligate receptor co-receptor (Orco) on the dendritic membrane of ORN (10). Orco is essential for proper dendritic trafficking of the OrX, facilitating the formation of odorant gated ion channels by structural alteration that is opened upon odorant binding (10), (15). Thus, it is plausible to hypothesize that prior blood meal, key interactions of odorants and their cognate receptors may have a significant influence on food choice decision and blood meal uptake process.…”

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confidence: 99%

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A synergistic transcriptional regulation of olfactory genes derives complex behavioral responses in the mosquito Anopheles culicifacies

Thomas

Verma

et al. 2017

Preprint

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Decoding the molecular basis of host seeking and blood feeding behavioral evolution/adaptation in the adult female mosquito may provide an opportunity to design new molecular strategy to disrupt human-mosquito interactions. However, despite the great progress in the field of mosquito olfaction and chemo-detection, little is known that how the sex-specific specialization of the olfactory system enables adult female mosquitoes to derive and manage complex blood feeding associated behavioral responses. A comprehensive RNAseq analysis of prior and post blood meal olfactory system of An. culicifacies mosquito revealed that a minor but unique change in the nature and regulation of key olfactory genes play a pivotal role in managing diverse behavioral responses. Age dependent transcriptional profiling demonstrated that adult female mosquito's chemosensory system gradually learned and matured to drive the host-seeking and blood feeding behavior at the age of 5-6 days. A zeitgeber time scale expression analysis of Odorant Binding Proteins (OBPs) unravels unique association with a late evening to midnight peak biting time. Blood meal-induced switching of unique sets of OBP genes and Odorant Receptors (ORs) expression coincides with the change in the innate physiological status of the mosquitoes. Blood meal follows up experiments provide enough evidence that how a synergistic and concurrent action of OBPs-ORs may drive 'prior and post blood meal' complex behavioral events. Finally, tissue-specific gene expression analysis and molecular modelling predicted two uncharacterized novel sensory appendages proteins (SAP-1 & SAP2) unique to An. culicifacies mosquito and may play a central role in the host-seeking behavior.Significance: Evolution and adaptation of blood feeding behavior not only favored the reproductive success of adult female mosquito but also make them an important disease vectors. Immediately after emergence, an environmental exposure may favor the broadly tuned olfactory system of mosquitoes to derive complex behavioral responses. But, how these olfactory derived genetic factors manage female specific 'pre and post' blood meal associated complex behavioral responses are not well known. We unraveled synergistic actions of olfactory factors governs an innate to prime learning strategy to facilitate rapid blood meal acquisition and downstream behavioral activities. A speciesspecific transcriptional profiling and an in-silico analysis predict novel 'sensory appendages protein', as a unique target to design disorientation strategy against the mosquito Anopheles culicifacies.. not peer-reviewed)

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Overwinter users of nest cavities affect breeding birds via nest‐dwelling ectoparasites

et al. 2023

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Cavities used for avian reproduction in spring often host other organisms for roosting during winter, which should affect their microclimatic conditions and, then, the patterns of emergence of nest-dwelling ectoparasites of birds and successful parasitism. To prove these cascade effects, we experimentally blocked the entrance of half of nest boxes previously used for reproduction by hoopoes (Upupa epops), recorded temperature and humidity during the fall-winter period, and evaluated abundance, emergence of ectoparasitic flies (Carnus hemapterus), and intensity of parasitism in hoopoe nestlings growing in open and blocked nest boxes the next spring. As expected, experimental treatment as well as the occupancy of open nest boxes by rodents (i.e., mainly dormice [Eliomys quercinus]) affected temperature and humidity, but did not predict the onset or duration of Carnus emergence. Moreover, flies were more abundant in open nest boxes and, among them, those occupied by dormice showed the lowest abundance. Finally, hoopoe nestlings developing in nest boxes blocked during winter experienced lower intensity of ectoparasitism than those in open nest boxes. These hitherto undescribed cryptic effects of overwinter occupants of nest cavities on subsequent emergence and viability of nest-dwelling ectoparasites would profoundly impact on the interaction with their avian hosts.

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Olfaction in vector-host interactions

Cited by 40 publications

References 662 publications

Genetic variation in the odorant receptor gene OR4 and bit habits in natural populations of Aedes aegypti from Antioquia department, Colombia

Genetic variation in the odorant receptor gene OR4 and bit habits in natural populations of Aedes aegypti from Antioquia department, Colombia

A synergistic transcriptional regulation of olfactory genes derives complex behavioral responses in the mosquito Anopheles culicifacies

Overwinter users of nest cavities affect breeding birds via nest‐dwelling ectoparasites

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