Olfactory abnormalities in anxiety disorders

Clepce, Marion; Reich, Karin; Gossler, Andrea; Kornhuber, Johannes; Thuerauf, Norbert

doi:10.1016/j.neulet.2012.01.034

Cited by 31 publications

(28 citation statements)

References 22 publications

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“…Previous literature has found anxiety to be significantly related to olfactory functioning (Clepce et al, 2012). For example, past studies have established that increased anxiety reactions occur following the presentation of, what are deemed as, fearful odorants (Albrecht et al, 2010;Clepce et al, 2012). Albrecht et al (2010) presented women participants with sweat from a fearful man.…”

Section: Introductionmentioning

confidence: 99%

“…When compared to controls who were presented neutral sweat, the women who were presented the fearinduced sweat showed a heightened anxiety response (Albrecht et al, 2010). Clepce et al (2012) tested the theory that anxiety is correlated to deficits in olfactory identification through an extended version of the Sniffin' Sticks identification test. This study used participants with diagnosed cases of various types of anxiety disorders (generalized anxiety disorder, social phobia, panic disorder, agoraphobia) and healthy control partici pants.…”

Section: Introductionmentioning

confidence: 99%

“…This study used participants with diagnosed cases of various types of anxiety disorders (generalized anxiety disorder, social phobia, panic disorder, agoraphobia) and healthy control partici pants. Researchers found that the anxiety group performed significantly worse on the discrimination task than the control group, although there were no group differences in identification and threshold (Clepce et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…These measures were chosen based on their psychometric properties, relevance to our study, and availability at our institution. Specifi cally, the SIAS was chosen to measure participants' selfreported experiences of anxiety during social interaction because increased social anxiety com monly coincides with diagnoses of schizophrenia and schizotypy (Clepce et al, 2012;Havlíček et al, 2012). Similarly, the BIS/BAS was chosen to mea sure selfreported instances of behavioral approach and avoidance in participants.…”

Section: Introductionmentioning

confidence: 99%

“…Previous literature has established that per formance on subjective and objective olfactory measures may be related to differing levels of atypical behavior (Auster et al, 2014;Brewer et al, 2005;Clepce et al, 2012;Havlíček et al, 2012;Ishizuka et al, 2010). Specifically, those who score low on the SPQB endorse a low amount or absence of atypical behaviors, while those who score high on the SPQB endorse a great amount of atypical behaviors.…”

Section: Introductionmentioning

confidence: 99%

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The Values of Psychological Science: Student and Faculty Perspectives on Research Ethics

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Values of Psychological Science: Student and Faculty Perspectives on Research Ethics

Corts¹,

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2019

PsiChiJournal

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A systematic review on olfaction in child and adolescent psychiatric disorders

et al. 2012

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There is substantial evidence that olfactory function may serve as biomarker in adult neuropsychiatric disorders, e.g. overall diminished olfaction in Parkinson's disease as parameter for early pre-motor and differential diagnosis. Here, we present data from a systematic literature review in olfactory function in child and adolescent psychiatric disorders and report two unpublished data sets of autism and obsessive-compulsive disorder. The overall number of olfaction studies is low-even after taking into account adult samples. In addition, heterogeneity of findings is high due to methodological limitations such as the use of different olfactory tests and odours targeting the olfactory and/or the trigeminal system and neglecting possible confounders, e.g., intelligence or oto-rhino-laryngological affections. Despite these limitations, there is some indication for specific alterations of olfactory function especially in disorders with dopaminergic pathology (e.g. attention deficit/hyperactivity disorder, autism, schizophrenia, 22q11 deletion syndrome). Dopamine is a relevant modulator of early processes in the olfactory bulb. Our systematic review provides the basis for future confirmatory studies investigating olfaction as putative biomarker in child and adolescent psychiatric disorders. We further propose studies of thorough and elaborate methodological standards in combination with imaging techniques and the investigation of the influence of genetic variation on olfactory function.

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