Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

Lechien, Jérôme R.; Chiesa‐Estomba, Carlos Miguel; Siati, Daniele R. De; Horoi, Mihaéla; Bon, Serge D Le; Rodriguez, Alexandra; Dequanter, Didier; Blecic, Serge; Afia, Fahd El; Distinguin, Léa; Chekkoury‐Idrissi, Younès; Hans, Stéphane; Delgado, Irene López; Calvo‐Henríquez, Christian; Lavigne, Philippe; Falanga, Chiara; Barillari, Maria Rosaria; Cammaroto, Giovanni; Khalifé, Mohamad; Leich, Pierre; Souchay, Christel; Rossi, Camélia; Journé, Fabrice; Hsieh, Julien Wen; Edjlali, Myriam; Carlier, Robert; Ris, Laurence; Lovato, Andrea; Filippis, Cosimo de; Coppée, Frédérique; Fakhry, Nicolas; Ayad, Tareck; Saussez, Sven

doi:10.1007/s00405-020-05965-1

Cited by 2,440 publications

(3,602 citation statements)

References 27 publications

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“…In conclusion, in this Italian cohort, the majority were men older than 60 years with at least one comorbidity in nearly 60%. A self-reported anosmia and/or dysgeusia were frequent symptoms similar to what has been described in a recent European and Italian study [3,4]. The rising intensity of care seemed to reduce the ICU transfer rate and endotracheal intubation.…”

Section: Discussionsupporting

confidence: 77%

“…It was not possible to precisely estimate if these symptoms preceded or followed those that prompted medical referral. However, anosmia and dysgeusia should be considered as possible clinical indication of COVID-19 and lead to further investigation including testing for infection with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) [4].…”

Section: Discussionmentioning

confidence: 99%

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Early experience of an infectious and tropical diseases unit during the coronavirus disease (COVID-19) pandemic, Florence, Italy, February to March 2020

et al. 2020

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We analysed the first 84 coronavirus disease (COVID-19) patients hospitalised in an infectious and tropical disease unit in Florence, Italy, over 30 days after the start of the COVID-19 outbreak in Italy. A 12% reduction in the rate of intensive care unit transfer was observed after the implementation of intensity care measures in the regular ward such as increasing the nurse/patient ratio, presence of critical care physicians and using high flow nasal cannulae oxygenation.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Early experience of an infectious and tropical diseases unit during the coronavirus disease (COVID-19) pandemic, Florence, Italy, February to March 2020

et al. 2020

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“…The Hopkins team published the first case report and case series suggesting that sudden olfactory dysfunction, should be considered highly suspicious for SARS-CoV-2 [4,6]. Moreover, our study group recently showed, that anosmia was present in 86% in a series of 417 patients with mild-to-moderate COVID-19 disease, and appeared before other symptoms in 11.8% [5]. In the same way, Kaye et al described in a series of 237 patients that anosmia was noted in 73% of subjects prior to COVID-19 diagnosis and was the initial symptom in 26.6% [11].…”

Section: Discussionmentioning

confidence: 89%

Objective olfactory testing in patients presenting with sudden onset olfactory dysfunction as the first manifestation of confirmed COVID-19 infection

Lechien

Cabaraux

Chiesa‐Estomba

et al. 2020

Preprint

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Background: The aims of this study are to investigate the COVID-19 status of patients with initial sudden olfactory anosmia (ISOA) using nasopharyngeal swabs for RT-PCR analysis and to explore their olfactory dysfunctions with psychophysical olfactory evaluation. Methodology: This prospective study included 78 ISOA patients who fulfilled a patient-reported outcome questionnaire and underwent a nasopharyngeal swabs. Among these, 46 patients performed psychophysical olfactory evaluation using sniffing tests. Based on the duration of the ISOA, two groups of patients were compared: patients with anosmia duration ≤12 days (group 1) and those with duration >12 days (group 2). Results: Among group 1, 42 patients (87.5%) had a positive viral load regarding RT-PCR while 6 patients (12.5%) were negative. In group 2, 7 patients (23%) had a positive viral load and 23 patients (77%) were negative. Among the 46 patients having performed a psychophysical olfactory evaluation, we observed anosmia in 52% (N=24), hyposmia in 24% (N=11) and normosmia in 24% (N=11) of patients. The viral load significantly decreased throughout the 14-days following the onset of the olfactory disorder. Conclusions: Our results support that a high proportion of ISOA patients are Covid+. Our study supports the need to add anosmia to the list of symptoms used in screening tools for possible COVID-19 infection.

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“…Apart from neurodegenerative diseases, the three major causes of a loss of smell are trauma, rhinosinusitis/nasal polyps, and viral infections [48]. Olfactory and gustatory dysfunctions have now been reported as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19) [49].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

Horowitz¹,

Freeman²,

Bruzzese

2020

Respiratory Medicine Case Reports

165

156

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Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

Cited by 2,440 publications

References 27 publications

Early experience of an infectious and tropical diseases unit during the coronavirus disease (COVID-19) pandemic, Florence, Italy, February to March 2020

Early experience of an infectious and tropical diseases unit during the coronavirus disease (COVID-19) pandemic, Florence, Italy, February to March 2020

Objective olfactory testing in patients presenting with sudden onset olfactory dysfunction as the first manifestation of confirmed COVID-19 infection

Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

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