Olfactory discrimination between glycine and deuterated glycine by fish

Hara, Jun

doi:10.1007/bf01946534

Cited by 21 publications

(13 citation statements)

References 11 publications

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“…Partial deuteration of insect pheromones reduces electroantennogram response amplitudes [13]. Fish have been reported to be able to distinguish isotopomers of glycine by smell [14]. However, human trials using commercially available deuterated odorants [benzaldehyde and acetophenone] have yielded conflicting results, both positive [15] and negative [16].…”

Section: Introductionmentioning

confidence: 99%

Molecular Vibration-Sensing Component in Human Olfaction

et al. 2013

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Whether olfaction recognizes odorants by their shape, their molecular vibrations, or both remains an open and controversial question. A convenient way to address it is to test for odor character differences between deuterated and undeuterated odorant isotopomers, since these have identical ground-state conformations but different vibrational modes. In a previous paper (Franco et al. (2011) Proc Natl Acad Sci USA 108:9, 3797-802) we showed that fruit flies can recognize the presence of deuterium in odorants by a vibrational mechanism. Here we address the question of whether humans too can distinguish deuterated and undeuterated odorants. A previous report (Keller and Vosshall (2004) Nat Neurosci 7:4, 337-8) indicated that naive subjects are incapable of distinguishing acetophenone and d-8 acetophenone. Here we confirm and extend those results to trained subjects and gas-chromatography [GC]-pure odorants. However, we also show that subjects easily distinguish deuterated and undeuterated musk odorants purified to GC-pure standard. These results are consistent with a vibrational component in human olfaction.

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Section: Introductionmentioning

confidence: 99%

Molecular Vibration-Sensing Component in Human Olfaction

et al. 2013

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“…Subsequent studies were conducted on both the German and the American cockroaches with mixed results. Sugawara et al [32] and Havens and Meloan [33] Hara contextualized his results as altered molecular motion-vis-á-vis Wright's theoryin his report finding that whitefish (Coregonus clupeaformis) are capable of discriminating between glycine and d 5 -glycine in a behavioral study [34].…”

Section: Historical Vibrational Theoriesmentioning

confidence: 92%

Status of the Vibrational Theory of Olfaction

et al. 2018

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The vibrational theory of olfaction is an attempt to describe a possible mechanism for olfaction which is explanatory and provides researchers with a set of principles which permit predictions allowing for structure-odor relations. Similar theories have occurred several times throughout olfactory science; this theory has again recently come to prominence by Luca Turin, who suggested that inelastic electron tunneling is the method by which vibrations are detected by the olfactory receptors within the hose. This work is intended to convey to the reader an up-to-date account of the vibrational theory of olfaction, both the historical iterations as well as the present iteration. This text is designed to give a chronological account of both theoretical and experimental studies on the topic, while providing context, comments, and background where they were found to be needed.

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“…Early findings suggest that both the lake whitefish and the American cockroach can identify isotopologues of amino acids and pheromones, respectively 58 59 . Recent experiments have shown that the common fruit fly presents both naive bias to and a potential for trained aversion towards the isotopologues of acetophenone 60 , and reposte 61 .…”

Section: Proposed Experimentsmentioning

confidence: 99%

Neuroreceptor Activation by Vibration-Assisted Tunneling

Hoehn

Nichols

Neven

et al. 2015

Sci Rep

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G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous value for pharmacology and drug design. Inelastic electron tunneling spectroscopy (IETS) has been proposed as a model for the mechanism by which olfactory GPCRs are activated by a bound agonist. We apply this hyothesis to GPCRs within the mammalian nervous system using quantum chemical modeling. We found that non-endogenous agonists of the serotonin receptor share a particular IET spectral aspect both amongst each other and with the serotonin molecule: a peak whose intensity scales with the known agonist potencies. We propose an experiential validation of this model by utilizing lysergic acid dimethylamide (DAM-57), an ergot derivative, and its deuterated isotopologues; we also provide theoretical predictions for comparison to experiment. If validated our theory may provide new avenues for guided drug design and elevate methods of in silico potency/activity prediction.

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Olfactory discrimination between glycine and deuterated glycine by fish

Cited by 21 publications

References 11 publications

Molecular Vibration-Sensing Component in Human Olfaction

Molecular Vibration-Sensing Component in Human Olfaction

Status of the Vibrational Theory of Olfaction

Neuroreceptor Activation by Vibration-Assisted Tunneling

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