Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species

Cothren, Taitum O.; Evonko, Christopher J.; MacQueen, David A.

doi:10.1007/7854_2022_390

Cited by 5 publications

(3 citation statements)

References 100 publications

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“…Another GPR of interest to this pathology is the GPR-88 expression, which has been found mainly in the striatum in all neurons containing substance P but also in the olfactory tubercle and nucleus accumbens [ 35 ]. The olfactory tubercle has been proven to have smaller volumes in schizophrenic patients [ 22 ], while there are conflicting results about the volumes of nucleus accumbens in schizophrenia [ 36 ]. However, it has been proven that these neurons have a higher sensitivity to dopamine in schizophrenic patients [ 36 , 37 , 38 , 39 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…The olfactory tubercle has been proven to have smaller volumes in schizophrenic patients [ 22 ], while there are conflicting results about the volumes of nucleus accumbens in schizophrenia [ 36 ]. However, it has been proven that these neurons have a higher sensitivity to dopamine in schizophrenic patients [ 36 , 37 , 38 , 39 , 40 , 41 ]. For a more accurate image of the expression of GPCR in the brain, see Figure 2 below.…”

Section: Discussionmentioning

confidence: 99%

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Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia

Kalinovic,

Pascariu,

Vlad

et al. 2024

Pharmaceuticals

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The expression of GPCRs has been associated with schizophrenia, and their expression may induce morphological changes in brain regions responsible for schizophrenia and disease-specific behavioral changes. The articles included in this review were selected using keywords and databases of scientific research websites. The expressions of GPRs have different involvements in schizophrenia, some increase the risk while others provide protection, and they may also be potential targets for new treatments. Proper evaluation of these factors is essential to have a better therapeutic response with a lower rate of chronicity and thus improve the long-term prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia

Kalinovic,

Pascariu,

Vlad

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Central nervous system demyelinating diseases, including multiple sclerosis, are also associated with olfactory loss [ 45 ], and patients with other neurological disorders, such as epilepsy, exhibit olfactory dysfunction [ 46 ]. Olfactory loss is noted as a common symptom of psychiatric conditions including schizophrenia, bipolar disorder, and major depressive disorder [ 47 ], and an increase in olfactory function is associated with a decline in depression severity [ 48 ]. Traumatic brain injury can also induce olfactory dysfunction and may indicate other neurologic complications [ 49 ].…”

Section: Olfactory Dysfunction As a Symptom Of Neurologic And Psychia...mentioning

confidence: 99%

The Olfactory System: Basic Anatomy and Physiology for General Otorhinolaryngologists

Han,

Kim,

Cho

et al. 2023

Clin Exp Otorhinolaryngol

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Olfaction is one of the five basic human senses, and it is known to be one of the most primitive senses. The sense of olfaction may have been critical for human survival in prehistoric society, and although many believe its importance has diminished over time, its impact on human interaction, bonding, and propagation of the species remains. Even if we are unaware of it, the sense of smell greatly affects our lives. Sense of smell is closely related to overall quality of life and health. However, olfaction has been neglected from a scientific perspective compared to other senses. Olfaction has recently received substantial attention since the loss of smell and taste has been noted as a key symptom of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Studies investigating olfaction loss in association with coronavirus disease 2019 (COVID-19) have revealed that olfactory dysfunction can be both conductive and sensorineural, possibly causing structural changes in the brain. Olfactory training is one of the effective treatments for olfactory dysfunction, suggesting the reorganization of neural associations. Reduced ability to smell may also alert suspicion for neurodegenerative or psychiatric disorders. Here, we summarize the basic knowledge that we, as otorhinolaryngologists, should have about the sense of smell and the peripheral and central olfactory pathway for managing and helping patients with olfactory dysfunction.

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Differences in olfactory dysfunction and its relationship with cognitive function in schizophrenia patients with and without auditory verbal hallucinations

Wang

Ren

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species

Cited by 5 publications

References 100 publications

Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia

Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia

The Olfactory System: Basic Anatomy and Physiology for General Otorhinolaryngologists

Differences in olfactory dysfunction and its relationship with cognitive function in schizophrenia patients with and without auditory verbal hallucinations

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