Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals

Werner, Sabine; Nies, Eberhard

doi:10.1186/s12995-018-0209-6

Cited by 36 publications

(32 citation statements)

References 135 publications

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“…Our results suggested that compared to “white collar” workers, individuals with a manufacturing background exhibited accelerated olfactory decline, independently of sex and education. Findings from previous cross-sectional studies indicate that the exposure to certain work-related chemicals may harm the olfactory system ( 29 , 30 ). Note, however, that manufacturing profession did not survive as a predictor in the multi-adjusted model.…”

Section: Discussionmentioning

confidence: 97%

Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study

Ekström

Larsson

Rizzuto

et al. 2020

The Journals of Gerontology: Series A

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Background Olfactory dysfunction is common in aging and associated with dementia and mortality. However, longitudinal studies tracking change in olfactory ability are scarce. We sought to identify predictors of interindividual differences in rate of olfactory identification change in aging Methods Participants were 1,780 individuals, without dementia at baseline and with at least two olfactory assessments over 12 years of follow-up (mean age = 70.5 years; 61.9% female), from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). Odor identification was assessed with the Sniffin’ Sticks. We estimated the impact of demographic, health, and genetic factors on rate of olfactory change with linear mixed effect models Results Advancing age, manufacturing profession, history of cerebrovascular disease, higher cardiovascular disease burden, diabetes, slower walking speed, higher number of medications, and the APOE ε4 allele were associated with accelerated odor identification decline (ps < 0.014). Multi-adjusted analyses showed unique associations of age, diabetes, and ε4 to olfactory decline (ps < 0.017). In 1,531 participants who remained free of dementia (DSM IV criteria) during follow-up, age, cardiovascular disease burden, and diabetes were associated with accelerated decline (ps < 0.011). Of these, age and diabetes remained statistically significant in the multi-adjusted model (ps < 0.001) Conclusion Demographic, vascular, and genetic factors are linked to rate of decline in odor identification in aging. Although some olfactory loss may be an inevitable part of aging, our results highlight the importance of vascular factors for the integrity of the olfactory system, even in the absence of dementia

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Section: Discussionmentioning

confidence: 97%

Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study

Ekström

Larsson

Rizzuto

et al. 2020

The Journals of Gerontology: Series A

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show abstract

“…6,10 We speculate that exposure to certain xenobiotics, such as an HD, induces the inflammatory state and affects the lower airway 6,10 and nasal airway function. 11 A previous study reported an association of HD usage with asthma, 1 although they did not identify a dose-response relationship; another study reported an association with small airway impairment, 6 although they only examined 24 children. Our results were similar, except that we also identified dose-response relationships and examined larger numbers of children.…”

Section: Exposure To Humidifier Disinfectants Is Associated With Upper and Lower Airway Diseasesmentioning

confidence: 99%

Exposure to humidifier disinfectants is associated with upper and lower airway diseases

Yon

Lee

Woo

et al. 2020

Pediatric Allergy Immunology

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“…La anosmia/hiposmia puede ser manifestación de distintas patologías de base, las más frecuentes son enfermedades rinosinusales, trastornos posinfecciosos (infección respiratoria alta), y trastornos postraumáticos, otras etiologías menos frecuentes son causas congénitas, idiopáticas, tóxicos, y enfermedades neurodegenerativas 19 . Otra forma de clasificarlas son etiologías conductivas y/o traumáticas, y etiologías sensorioneurales, descritas en la Tabla 1, aunque algunas etiologías son mixtas, y en varios casos, no se ha logrado determinar la fisiopatología 15,[20][21][22][23][24][25][26] . Para una revisión de los medicamentos que puedan causar alteración del olfato, referimos al lector al artículo publicado por Susan S. Schiffman 27 .…”

Section: Patología Cuantitativaunclassified