Olfactory function in Parkinson's disease subtypes

Stern, Matthew B.; Rl, Doty; Dotti, Maria Teresa; Corcoran, Philip C.; Crawford, D. Beatty; McKeown, Donald A.; Adler, Cameron; Gollomp, Steven M.; Hurtig, Howard I.

doi:10.1212/wnl.44.2.266

Cited by 153 publications

(128 citation statements)

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“…The UPSIT scores showed marked impairment in the PD group, in contrast to the mild impairment in MSA patients and normal olfaction in PSP patients [15]. These results [27,29,30], which was confirmed by the present study. Studies that examined the correlation between pathological changes in the brain and results of olfactory tests suggested that olfactory dysfunction in MSA could be related to glial cytoplasmic inclusions in the olfactory bulb [31].…”

Section: Discussionsupporting

confidence: 89%

2.112 the Odor Stick Identification Test for Japanese Differentiates Parkinson's Disease From Multiple System Atrophy and Progressive Supra Nuclear Palsy

Suzuki¹,

Yoshioka²,

Hashimoto³

et al. 2012

Parkinsonism & Related Disorders

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Section: Discussionsupporting

confidence: 89%

2.112 the Odor Stick Identification Test for Japanese Differentiates Parkinson's Disease From Multiple System Atrophy and Progressive Supra Nuclear Palsy

Suzuki¹,

Yoshioka²,

Hashimoto³

et al. 2012

Parkinsonism & Related Disorders

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“…The possible rapid degeneration of the olfactory system early in the course of PD may provide one explanation for why olfactory dysfunction has traditionally been observed to be a static phenomenon in PD, although significant questions remain surrounding this issue. While initially described as unrelated to the progression of disease in PD [2] , olfactory dysfunction was found to correlate with PD subtype by Stern et al [51] : olfaction was more impaired in those with Hoehn and Yahr stage III or greater ('malignant') PD than in those with Hoehn and Yahr stage II or less for 4 or more years ('benign'). Recent studies have suggested that an even closer link may be found between PD progression and olfactory dysfunction.…”

Section: Olfactory Loss As a Biomarker Of Pdmentioning

confidence: 98%

Olfactory Dysfunction in Parkinson’s Disease

Kranick

Duda²

2007

Neurosignals

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Prior to the onset of the cardinal motor features of idiopathic Parkinson‘s disease (PD), other manifestations of neurodegeneration such as olfactory dysfunction are often apparent. Characterizing these potential biomarkers of preclinical PD is particularly important in identifying individuals who will go on to develop disabling symptoms, and thus be good candidates for new neuroprotective strategies. As shown by the Braak neuropathologic staging of PD, the olfactory system is among the first neuronal populations to display Lewy body pathology. Clinically, loss of smell can be easily tested in the office using several validated techniques and is often helpful to the physician in distinguishing idiopathic PD from other forms of parkinsonism. Recent findings have indicated that a decline in olfaction may be observed in selected at-risk patients, which has significant implications for identifying potential study populations. Ongoing studies of olfactory dysfunction may also reveal potential for use as a medication-independent biomarker of disease progression in addition to use as a biomarker for the diagnosis of PD.

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“…Sensory symptoms (olfactory dysfunction, pain, paresthesia, akathisia, oral pain and genital pain) are frequent in PwP, but are often not recognised as parkinsonian symptoms [21,46,25,10].…”

Section: Motor Symptomsmentioning

confidence: 99%

User interface design guidelines for smartphone applications for people with Parkinson’s disease

Nunes

Silva

Cevada

et al. 2015

Univ Access Inf Soc

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Parkinson's disease (PD) is often responsible for difficulties in interacting with smartphones; however, research has not yet addressed these issues and how these challenge people with Parkinson's (PwP). This paper specifically investigates the symptoms and characteristics of PD that may influence the interaction with smartphones to then contribute in this direction. The research was based on a literature review of PD symptoms, eight semi-structured interviews with healthcare professionals and observations of PwP, and usability experiments with 39 PwP. Contributions include a list of PD symptoms that may influence the interaction with smartphones, a set of experimental results that evaluated the performance of four gestures tap, swipe, multiple-tap, and drag and 12 user interface design guidelines for creating smartphone user interfaces for PwP. Findings contribute to the work of re-

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Olfactory function in Parkinson's disease subtypes

Cited by 153 publications

References 0 publications

2.112 the Odor Stick Identification Test for Japanese Differentiates Parkinson's Disease From Multiple System Atrophy and Progressive Supra Nuclear Palsy

2.112 the Odor Stick Identification Test for Japanese Differentiates Parkinson's Disease From Multiple System Atrophy and Progressive Supra Nuclear Palsy

Olfactory Dysfunction in Parkinson’s Disease

User interface design guidelines for smartphone applications for people with Parkinson’s disease

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