Olfactory Function Is Impaired in Patients with Mastocytosis

Masala, Carla; Firinu, Davide; Piras, Raffaella; Deidda, Margherita; Cinetto, Francesco; Giacco, Stefano Del

doi:10.1016/j.jaip.2020.09.061

The Journal of Allergy and Clinical Immunology: In Practice

2021

DOI: 10.1016/j.jaip.2020.09.061

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Olfactory Function Is Impaired in Patients with Mastocytosis

Carla Masala

Davide Firinu

Raffaella Piras

et al.

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Cited by 2 publications

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“…Additionally, previous studies have revealed that olfactory function is impaired in patients diagnosed with mastocytosis, as demonstrated by Masala et al [6], but the pathomechanisms are yet to be demonstrated. Furthermore, Serrao et al [7] utilized top-down proteomics to uncover significant variations in the protein profile of human saliva in individuals afflicted with mastocytosis, underscoring the potential of salivary biomarkers in disease detection and monitoring.…”

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confidence: 92%

Unraveling the Complexities of Mast Cells in Health and Disease

Firinu

2024

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confidence: 92%

Unraveling the Complexities of Mast Cells in Health and Disease

Firinu

2024

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Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review

Sagües‐Sesé,

García‐Casares,

Álvarez‐Twose

2023

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BackgroundMastocytosis manifests with multisystemic symptoms, often involving the nervous system. Numerous cognitive, neuropsychiatric and neurological alterations have been reported in multiple observational studies.MethodsWe performed a qualitative systematic literature review of reported data consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2023.ResultsWe selected 24 studies in which the majority showed that a high proportion of mastocytosis patients suffer cognitive, neuropsychiatric and neurological alterations. The most common disorders and estimated ranges of frequency observed in adults were depression (68%–75%), anxiety, high stress or irritability (27%–54%), cognitive impairment (27%–39%, primarily affecting memory skills), and headaches (55%–69%). Attention challenges and learning difficulties were reported in children at a rate of 13%, while neurodevelopmental disorders occurred at rates of 8%–12%. Frequent white abnormalities in mastocytosis patients with concomitant psychocognitive symptoms have been reported although neuroimaging studies have been performed rarely in this population.ConclusionFurther studies with more comprehensive and homogeneous evaluations and neuroimaging and histological analysis should be performed for a better understanding of these manifestations. An earlier detection and proper management of these symptoms could greatly improve the quality of life of these patients.

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Olfactory Function Is Impaired in Patients with Mastocytosis

Cited by 2 publications

References 33 publications

Unraveling the Complexities of Mast Cells in Health and Disease

Unraveling the Complexities of Mast Cells in Health and Disease

Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review

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