Olfactory neuroblastoma: An immunohistochemical, ultrastructural, and flow cytometric study

Vartanian, Robert K.

doi:10.1002/(sici)1097-0142(19960501)77:9<1957::aid-cncr30>3.0.co;2-x

Cited by 5 publications

(1 citation statement)

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“…Esthesioneuroblastoma (ENB), also named olfactory neuroblastoma, is a rare malignant neoplasm that arises from the olfactory epithelium. ENB represents only 3% to 6% of all cancers in the nasal cavity and paranasal sinuses, but the true incidence is rising due to an increase in detection by histopathologic examination through immunohistochemistry, electron microscopy, and molecular investigations (1)(2)(3) .…”

Section: Introductionmentioning

confidence: 99%

Elective neck irradiation in the management of esthesioneuroblastoma: a systematic review and meta-analysis

Costantino¹,

Sebastiani²,

Russo³

et al. 2021

Rhin

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Background: There is no consensus about the optimal management of the neck in clinically node negative esthesioneuroblastoma (ENB). The aim of this study is to assess the impact of elective neck irradiation (ENI) in terms of regional disease control and survival. Methods: The study was performed according to the PRISMA guidelines searching on Scopus, PubMed/MEDLINE, and Google Scholar databases. The primary outcome was the regional recurrence rate (RRR), that was reported as odds ratio (OR) and 95% confidence interval (CI). Secondary outcomes were the overall survival (OS), and the distant-metastases free survival (DMFS), that were reported as logarithm of the hazard ratios (logHRs) and 95% confidence intervals (CIs). Results: A total of 489 clinically node negative patients were included from 9 retrospective studies. ENI significantly reduced the risk of regional recurrence compared to no treatment. No difference was measured between ENI and observation, according to both OS and DMFS. No stratified analysis could be performed based on Kadish stage and Hyams grade. Conclusions: ENI should be recommended to improve the regional disease control. No advantage was measured in terms of survival or distant metastases with a low quality of evidence. Further prospective studies should be designed to understand if ENI could be avoided in early stage and low-grade tumors.

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Section: Introductionmentioning

confidence: 99%