Olfactory screening test in mild cognitive impairment

Eibenstein, Alberto; Fioretti, Alessandra; Simaskou, Maria; Sucapane, Patrizia; Mearelli, S.; Mina, Concetta; Amabile, G; Fusetti, Marco

doi:10.1007/s10072-005-0453-2

Cited by 78 publications

(52 citation statements)

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“…The sensitivity and specificity of B-SIT was remarkably high in our Norwegian population, with the ROC-curve showing even greater discrimination than previous studies (Suzuki et al, 2004;Eibenstein et al, 2005). According to the present study a score of >8 was the best cut-off to distinguish patients with AD from healthy controls of the same age.…”

Section: Discussionmentioning

confidence: 38%

Use of the Brief Smell Identification Test for olfactory deficit in a Norwegian population with Alzheimer's disease

Kjelvik

Sando

Aasly

et al. 2007

Int J Geriat Psychiatry

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Section: Discussionmentioning

confidence: 38%

Use of the Brief Smell Identification Test for olfactory deficit in a Norwegian population with Alzheimer's disease

Kjelvik

Sando

Aasly

et al. 2007

Int J Geriat Psychiatry

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“…The score can range from 0 to 30 points and is adjusted according to age and level of education [9]. A cut-off score [24 was utilized to discern MCI and early AD patients [15].…”

Section: Mini-mental State Examinationmentioning

confidence: 99%

Taste in mild cognitive impairment and Alzheimer’s disease

et al. 2009

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In this prospective study we investigated the quantitative and qualitative taste function of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). 29 healthy, elderly subjects, 29 MCI and 30 AD patients were tested using a validated taste test, the "taste strips". Additionally, odor identification, odor discrimination, odor threshold, the mini-mental state examination (MMSE) and Apo E epsilon 4 status were examined. Regarding taste, there was a significant reduction of total taste scores and also the score for individual tastes on either side of the tongue between controls and MCI/AD patients. There was no significant difference in the taste scores between MCI and AD patients. A taste test may be a useful procedure for differentiating between healthy subjects and patients with MCI/AD in a clinical context. For diagnosing MCI versus AD, further tests such as smell test, MMSE, Apo E epsilon 4 status, FDG-PET and MRI appear to be useful.

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“…In addition, not only depression but a whole list of neurological diseases [68], Alzheimer's disease [69], and multiple sclerosis [70] causes taste and smell disturbances in human patients. In our experiments, we could observe a decrease in vanillin/sucrose solution intake by aggressive males who had won many fights and whose behavior was utterly devoid of any sign of depression.…”

Section: Discussionmentioning

confidence: 99%

Anhedonia in the Shadow of Chronic Social Defeat Stress, or when the Experimental Context Matters

Bondar

Kovalenko²,

Августинович³

et al. 2009

TOBSJ

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One of the core symptoms of major depression in human is anhedonia. For that reason, one of the main requirements towards experimental depression models is that they be able to demonstrate anhedonia in animals, that have been exposed to stressful events, and other behavioral changes attributable to a depression-like state. However, the results presented in the literature are contradictory: sweet solution intake, which is considered as a parameter of hedonic/anhedonic behavior in animals, responds quite differently to stressful situations in that it is either unaffected or increased or decreased. Different experimental designs used for the study of anhedonia in male mice exposed to chronic social defeat stress were tried to understand the reasons for so contradictory responses. Anhedonia appears as an abrupt reduction in sweet solution consumption in stressed animals and by failure to attain recovery after deprivation. However, it was also demonstrated that sucrose solution intake and preference strongly depend on the experimental context; that the possible critical factor may be prior acquaintance with the hedonic stimulus -or the lack whereof. Analysis of literature data and ours allowed us to conclude that the lack of a significant decrease in sweet solution intake in stressed animals is no evidence of lack of depression. This decrease is evidence of anhedonia only provided other symptoms of depression are present. Hedonic consumable intake can be decreased over various motivations, conditions or diseases, in particular, a high level of anxiety or pathological aggression.

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Olfactory screening test in mild cognitive impairment

Cited by 78 publications

References 0 publications

Use of the Brief Smell Identification Test for olfactory deficit in a Norwegian population with Alzheimer's disease

Use of the Brief Smell Identification Test for olfactory deficit in a Norwegian population with Alzheimer's disease

Taste in mild cognitive impairment and Alzheimer’s disease

Anhedonia in the Shadow of Chronic Social Defeat Stress, or when the Experimental Context Matters

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