Olfactory Sensations During Radiation Sessions: A Review

Sasai, Keisuke

doi:10.1016/j.adro.2022.101119

Cited by 5 publications

(12 citation statements)

References 13 publications

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“…The existence of illusions in senses other than visual [26] , [55] , [61] , [63] , [64] , the inverse effect on electroretinogram and on cortical evoked potentials following concurrent light and ion stimulation [46] strongly suggest cortical interactions and therefore requires models that are not relying just on the retina. These models are still lacking, and further studies should be promoted in this sense.…”

Section: Discussionmentioning

confidence: 99%

“…In these cases the most important key parameters were linked to tumor location and dose. For the detailed considerations related to these the reader is addressed to the original papers (see also [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] ). Most of the studies were prospective studies where the patient was aware of the study, and accepted it before the therapy, and was asked questions about the illusions immediately after each therapy session.…”

Section: Proton/hadron-therapy a New Channel To Study Lfmentioning

confidence: 99%

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Light flashes and other sensory illusions perceived in space travel and on ground, including proton and heavy ion therapies

Narici

2024

Zeitschrift für Medizinische Physik

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Section: Discussionmentioning

confidence: 99%

Section: Proton/hadron-therapy a New Channel To Study Lfmentioning

confidence: 99%

Light flashes and other sensory illusions perceived in space travel and on ground, including proton and heavy ion therapies

Narici

2024

Zeitschrift für Medizinische Physik

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“…Therefore, it should be kept in mind that the inclusion of the visual pathway or nasal cavity in the irradiation range in pediatric cases makes it likely that the patient will sense light and odor. Sasai et al review on odors during RT [ 11 ]. Due to the paucity of articles on odor during RT, only 12 articles were included in the review, including case reports.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of the Areas Responsible for Light Flash and Odor During Proton Beam Therapy and Photon Therapy

Oshiro,

Mizumoto,

Miyamoto

et al. 2023

Cureus

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Background Abnormal sensations were frequently experienced by patients who received irradiation of the brain or head and neck region. We have previously suggested correlations with irradiation of the nasal cavity and retina. Purpose We performed a retrospective dose-volume histogram analysis focused on the brain and head and neck tumor to examine the relationship between these abnormal sensations and the details of irradiation. Methods Multivariate logistic regression models were applied for the presence or absence of light flash and odor. Gender, age, radiotherapy method (proton beam therapy vs. photon radiotherapy), dose of retina, optic nerve, chiasmatic gland, pituitary, nasal cavity, oral cavity, frontal lobe, parietal lobe, occipital lobe, temporal lobe, amygdala, and hippocampus were set as candidates of explanatory variables. Results Light flash and odor during radiotherapy have been suggested to be associated with younger age and retina and nasal cavity irradiation. Multivariate analyses including dose-volume histograms indicated that light flash was related to age, chiasmatic gland irradiation, and pituitary dose, and odor was related to age and nasal cavity irradiation. Conclusion Our results indicate that light flash during radiotherapy is caused by irradiation of the visual pathway and that odor is caused by irradiation of the nasal cavity or olfactory bulb.

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“…However, phantosmia and phosphene are rare among the general population and uncommon among the clinical population. Furthermore, although abnormal sensations generally do not interrupt the treatment [ 6 ], they sometimes irritate patients and may reduce their compliance [ 7 ]. Hence, to improve treatment compliance and provide adequate management, it is important to understand the clinical characteristics of these phenomena.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, emerging studies on this topic made significant contributions. Based on what has been reported, percepts of ozone, burnt sensations and chemical-like smells are typical for phantosmias [ 6 ], and blue, purple and yellow are common colors in phosphene during RT [ 8 ]. Although heterogeneous, the intensity of these unusual sensations ranges from mild to moderate, and usually would disappear after RT has been finished [ 1 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Abnormal visual and olfactory sensations during radiation therapy: a prospective study

et al. 2023

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Purpose Patients sometimes report phosphene and phantosmia during radiation therapy (RT). However, the detail features and related factors are not well understood. Our prospective study aimed to investigate the characteristics of phantosmias and phosphenes, to identify factors that influence the occurrence, intensity and hedonic (pleasantness/unpleasantness) ratings of such sensations during RT. Methods We included a total of 106 patients (37 women), who underwent RT in regions of the brain, ear, nose, throat (ENT), and other areas of the body for a duration of 43 ± 5 days. Medical history and treatment parameters were collected in a structured medical interview. Olfactory function was measured using the Sniffin’ Stick Odor Identification Test at baseline. Phantosmia and phosphene were recorded weekly based on a self-report questionnaire. Results There were 37% of the patients experiencing phantosmias, 51% experiencing phosphenes, and 29% simultaneously experiencing both sensations. Phosphenes were typically perceived as a flashily blue, white and/or purple light, phantosmias were typically perceived as a chemical-like, metallic or burnt smell. Younger age (F = 7.81, p < 0.01), radiation in the brain region (χ2 = 14.05, p = 0.02), absence of taste problems (χ2 = 10.28, p = 0.01), and proton RT (χ2 = 10.57, p = 0.01) were related to these abnormal sensations. History of chemical/dust exposure predicted lower intensity (B = −1.52, p = 0.02) and lower unpleasantness (B = 0.49, p = 0.03) of phantosmia. In contrast, disease (tumor) duration (B = 0.11, p < 0.01), food allergy (B = 2.77, p < 0.01), and epilepsy (B = −1.50, p = 0.02) influence phosphenes intensity. Analgesics intake predicted a higher pleasantness of the phosphenes (B = 0.47, p < 0.01). Conclusions Phantosmias and phosphenes are common during RT. The treatment settings and individual arousal level influence the occurrence, intensity and hedonic of such abnormal sensations. Phantosmias and phosphenes may involve more central neural than peripheral mechanism, and they could be elicited with activation of areas that are not regarded to be part of the olfactory or visual network.

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Olfactory Sensations During Radiation Sessions: A Review

Cited by 5 publications

References 13 publications

Light flashes and other sensory illusions perceived in space travel and on ground, including proton and heavy ion therapies

Light flashes and other sensory illusions perceived in space travel and on ground, including proton and heavy ion therapies

Retrospective Analysis of the Areas Responsible for Light Flash and Odor During Proton Beam Therapy and Photon Therapy

Abnormal visual and olfactory sensations during radiation therapy: a prospective study

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