Olfactory sensory neuron‐specific and sexually dimorphic expression of protocadherin 20

Lee, Wooje; Cheng, Ting Wen; Gong, Qizhi

doi:10.1002/cne.21569

Cited by 21 publications

(15 citation statements)

References 91 publications

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“…Most of the markers are also likely expressed in neurons because: 1) a significant portion of Cntn3+, Ntng2+, and Cdh7 + cells are from the Rorβ + population, suggesting that the majority of these cells are neurons (Fig. , Table ); 2) SP, PV, and VIP label neurons in other systems, including the cortex and retina (Bagnoli et al, ; Markram et al, ; Huang et al, ; Park et al, ); and 3) Cdh6 and Pcdh20 likewise are expressed in neurons in other systems, including the retina and the olfactory system (Lee et al, ; Kay et al, ).…”

Section: Discussionmentioning

confidence: 99%

Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus

Byun

Kwon

Ahn

et al. 2016

J of Comparative Neurology

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The superior colliculus (SC) is a midbrain center involved in controlling head and eye movements in response to inputs from multiple sensory modalities. Visual inputs arise from both the retina and visual cortex and converge onto the superficial layer of the SC (sSC). Neurons in sSC send information to deeper layers of SC and to thalamic nuclei that modulate visually guided behaviors. Presently, our understanding of sSC neurons is impeded by a lack of molecular markers that define specific cell types. To better understand the identity and organization of sSC neurons, we took a systematic approach to investigate gene expression within four molecular families: transcription factors, cell adhesion molecules, neuropeptides and calcium binding proteins. Our analysis revealed 12 molecules with distinct expression patterns in mouse sSC: cadherin 7, contactin 3, netrin G2, cadherin 6, protocadherin 20, retinoid-related orphan receptor β, brain-specific homeobox/POU domain protein 3b, Ets variant gene 1, substance P, somatostatin, vasoactive intestinal polypeptide and parvalbumin. Double labeling experiments, by either in situ hybridization or immunostaining, demonstrated that the 12 molecular markers collectively define 10 different sSC neuronal types. The characteristic positions of these cell types divide sSC into 4 distinct layers. The 12 markers identified here will serve as valuable tools to examine molecular mechanisms that regulate development of sSC neuron types. These markers could also be used to examine the connections between specific cell types that form retinocollicular, corticocollicular or colliculothalamic pathways.

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Section: Discussionmentioning

confidence: 99%

Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus

Byun

Kwon

Ahn

et al. 2016

J of Comparative Neurology

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“…During postnatal development, in addition to the ingrowth of OSN axons, several developmental events are progressing simultaneously. Developmental events contributing to the formation of glomeruli include olfactory axon terminal arborization within the glomeruli, ingrowth of immature olfactory sensory axons, maturation of innervated olfactory axons (from GAP43‐positive to OMP‐positive), ingrowth of periglomerular neuron dendrites, and elaboration of mitral cell dendritic tufts within the glomeruli (Halász and Greer,1993; Malun and Brunjes,1996; Klenoff and Greer,1998; Lee et al,2008). Therefore, short‐term decreased GAP43‐positive axon ingrowth may not necessarily alter the sizes of the existing glomeruli.…”

Section: Discussionmentioning

confidence: 99%

Olfactory sensory axon growth and branching is influenced by sonic hedgehog

Gong

Chen

Farbman

2009

Developmental Dynamics

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Olfactory sensory neuron (OSN) axons extend from the olfactory epithelium to the olfactory bulb without branching until they reach their target region, the glomerulus. In this report, we present evidence to support the involvement of sonic hedgehog in promoting rat olfactory sensory axons to branch and to enter into the glomerulus. Sonic hedgehog (Shh) protein is detected in the glomeruli of the olfactory bulb, whereas its transcript is expressed in the mitral and tufted cells, suggesting that Shh in the glomeruli is produced by mitral and tufted cells. In primary OSN cultures, Shh-N peptide promotes olfactory axon branching. When Shh function is neutralized in vivo by its antibody, growth of newly generated OSN axons into the glomeruli is vastly reduced.

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“…The null mutation of genes encoding cell recognition molecules of the L1 family, like CHL1 and NrCAM , disturbs the guidance of the olfactory nerve, although in the CHL1 −/− / NrCAM −/− double-mutant mice there is no enhancement of the single mutant's phenotype (Heyden et al, 2008). Likewise, the recent detection of calcium-dependent adhesion molecules in the olfactory system, like cadherins (Akins et al, 2007), and especially protocadherin-20 in newly differentiated OSNs (Lee et al, 2008), has opened new perspectives to explain the formation of the olfactory nerve. It has also been shown that null mutation of the gene encoding the enzyme that produces the glycan lactosamine (β 1,3-N ′ -acetylglucosaminyltransferase1 - GnT1 -β 3GnT1 -) results in the normal outgrowth of olfactory axons to the OB, although at least some of them (i.e.…”

Section: From the Olfactory Epithelium To The Olfactory Bulb: Cellulamentioning

confidence: 99%

Wiring olfaction: the cellular and molecular mechanisms that guide the development of synaptic connections from the nose to the cortex

Castro

2009

Front. Neurosci.

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Within the central nervous system, the olfactory system fascinates by its developmental and physiological particularities, and is one of the most studied models to understand the mechanisms underlying the guidance of growing axons to their appropriate targets. A constellation of contact-mediated (laminins, CAMs, ephrins, etc.) and secreted mechanisms (semaphorins, slits, growth factors, etc.) are known to play different roles in the establishment of synaptic interactions between the olfactory epithelium, olfactory bulb (OB) and olfactory cortex. Specific mechanisms of this system (including the amazing family of about 1000 different olfactory receptors) have been also proposed. In the last years, different reviews have focused in partial sights, specially in the mechanisms involved in the formation of the olfactory nerve, but a detailed review of the mechanisms implicated in the development of the connections among the different olfactory structures (olfactory epithelium, OB, olfactory cortex) remains to be written. In the present work, we afford this systematic review: the different cellular and molecular mechanisms which rule the formation of the olfactory nerve, the lateral olfactory tract and the intracortical connections, as well as the few data available regarding the accessory olfactory system. These mechanisms are compared, and the implications of the differences and similarities discussed in this fundamental scenario of ontogeny.

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Olfactory sensory neuron‐specific and sexually dimorphic expression of protocadherin 20

Cited by 21 publications

References 91 publications

Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus

Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus

Olfactory sensory axon growth and branching is influenced by sonic hedgehog

Wiring olfaction: the cellular and molecular mechanisms that guide the development of synaptic connections from the nose to the cortex

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