2024
DOI: 10.1002/ange.202412106
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Oligo‐Adenine Derived Secondary Nucleic Acid Frameworks: From Structural Characteristics to Applications

Yuwei Hu,
Itamar Willner

Abstract: Oligo‐adenine (polyA) is primarily known for its critical role in mRNA stability, translational status, and gene regulation. Beyond its biological functions, extensive research has unveiled the diverse applications of polyA. In response to environmental stimuli, single polyA strands undergo distinctive structural transitions into diverse secondary configurations, which are reversible upon the introduction of appropriate counter‐triggers. In this review, we systematically summarize recent advances of noncanonic… Show more

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