Oligoclonal gammopathy in ataxia-telangiectasia

Löwenthal, A.; Adriaenssens, K.; Colfs, B.; Karcher, D.; Heule, R. Van

doi:10.1007/bf00316426

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…Nevertheless, some still show local synthesis of bands which are not transferred from the serum. 46 In adrenoleukodystrophy, in which there is no obvious aetiology for the oligoclonal response-the presence of abnormal long chain fatty acids may have a kind of "adjuvant" effect to allow the consequent production of intrathecal immunoglobulins. 47 It may also be worth noting a list of diseases in which we have not found local synthesis of oligoclonal bands as previous techniques may have yielded differing results (table 3).2 The presence of oligoclonal bands in both serum and CSF, the so-called "mirror" pattern, has different connotations which will be considered under the next section concerning the differential diagnosis of two of the five types of banding patterns seen on isoelectric focusing.…”

Section: Oligoclonal Bands and Mri Are Complementary For Diagnosis Ofmentioning

confidence: 99%

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Cerebrospinal fluid.

Thompson¹

1995

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Oligoclonal Bands and Mri Are Complementary For Diagnosis Ofmentioning

confidence: 99%

“…Total (46) the total IgG population is bound to nitrocellulose regardless of antigenic specificity. Some patients with multiple sclerosis have systemic bands which must be giving us some clue concerning the pathogenesis of this disease.…”

Section: Differential Diagnosis Of Mirror Pattern Oligoclonal Bands (mentioning

confidence: 99%

Cerebrospinal fluid.

Thompson¹

1995

Journal of Neurology, Neurosurgery & Psychiatry

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“…Triclonal gammopathies [61][62][63][64][65] or oligoclonal gammopathies [66][67][68] have been also reported. The identification of multiple clonal Igs are dependent on the sensitivity of the technique utilized.…”

Section: Biclonal Triclonal Oligoclonal Gammopathiesmentioning

confidence: 99%

The immunoglobulinopathies: From physiopathology to diagnosis

Tissot

Aubert

et al. 2002

Proteomics

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The diversity of immunoglobulins (Igs) results mainly from recombinations of numerous genes within the heavy (V(Heavy), D, and J(Heavy)) and within the light (V(Light), J(Light)) chain gene loci, and from somatic hypermutations occurring during the immune response of B-cells. Igs production is controlled by complex cellular and humoral mechanisms. Plasma of healthy individuals contains polyclonal Igs. Clonal expansion of cells producing antigen-specific Igs may result from physiological as well as from pathological immune events. Exquisitely sensitive and specific molecular biology techniques have been used to evaluate the clonal diversity of cells producing antigen-specific Ig. However, the application of such techniques is hampered by the necessity to collect the totality of antigen-specific B-cells for subsequent analysis, which is impossible to perform routinely in humans. In addition, these techniques do not provide quantitative information about the concentration of the circulating Igs. It is therefore necessary to use tools allowing study of the quantity of the circulating Igs, and more particularly to detect overproduction of a single homogeneous Ig resulting from the expansion of a B-cell clone secreting Igs. Here, we review the mechanisms of B-cell differentiation and Ig synthesis, discuss the diseases associated with clonal Ig production and review the methods available in the clinical laboratory for Ig analysis.

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Cerebrospinal Fluid Proteins in Pathology

Löwenthal

Karcher

1985

Pathological Neurochemistry

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Oligoclonal gammopathy in ataxia-telangiectasia

Cited by 6 publications

References 3 publications

Cerebrospinal fluid.

Cerebrospinal fluid.

The immunoglobulinopathies: From physiopathology to diagnosis

Cerebrospinal Fluid Proteins in Pathology

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