Oligodendroglioma of the Medulla Oblongata in a Neonate

Koeppen, Arnulf H.; Cassidy, Robert J.

doi:10.1001/archneur.1981.00510080082013

Cited by 10 publications

(7 citation statements)

References 20 publications

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“…Multiple lobar involvement is possible (34). Other sites for primary tumors include the cerebellum (3%), brainstem, spinal cord (1%), leptomeninges (so-called "oligodendrogliomatosis"), cerebellopontine angle, cerebral ventricles, retina, and optic nerve (1,8,12,15,(35)(36)(37)(38)(39)(40)(41). Primary leptomeningeal tumors are speculated to arise from glial heterotopias in this location (42).…”

Section: Epidemiologymentioning

confidence: 99%

Oligodendroglioma and Its Variants: Radiologic-Pathologic Correlation

Koeller¹,

Rushing²

2005

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Oligodendroglioma is the third most common glial neoplasm and most commonly arises in the frontal lobe. It occurs in males more frequently, and the peak manifestation is during the 5th and 6th decades. Children are affected much less commonly. The clinical presentation is often of several years duration with most patients presenting with seizures, reflecting the strong predilection of this tumor to involve the cortical gray matter. Current histopathologic classification schemes recognize two main types of tumors: well-differentiated oligodendroglioma and its anaplastic variant. Less commonly, neoplastic mixtures of both oligodendroglial and astrocytic components occur and are termed oligoastrocytomas, with both well-differentiated and anaplastic forms. Surgical resection is the mainstay of initial treatment, and many patients experience a long progression-free period. Recent genotyping has revealed chromosomal loss of 1p and 19q as a genetic signature in most oligodendrogliomas, and these tumors respond favorably to chemotherapy. Hence, radiation therapy is now generally reserved for partially resected tumors and cases that failed to benefit from chemotherapy. At cross-sectional imaging, the tumor characteristically involves the cortical gray matter and frequently contains calcification. Robust enhancement is not a common feature and suggests transformation to a higher histologic grade. Advanced magnetic resonance imaging techniques and metabolic imaging play increasingly important roles in both pre- and postoperative assessment of these complex neoplasms.

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Section: Epidemiologymentioning

confidence: 99%

Oligodendroglioma and Its Variants: Radiologic-Pathologic Correlation

Koeller¹,

Rushing²

2005

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“…The caveat mentioned above may apply to most of the cases in the literature reported as infratentorial oligodendrogliomas. Most published cases date to the era before LOH 1p/19q became a mainstay of diagnostic work‐up of oligodendrogliomas . Of the more recent reports, most either do not include molecular studies at all or demonstrate no or non‐specific genetic alterations .…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, only two cases of cerebellar oligodendrogliomas with loss of heterozygosity (LOH) of 1p and 19q – the genetical hallmark of oligodendrogliomas – have recently been described in the literature, while we are not aware of any report of genetically confirmed oligodendroglioma of the brain stem. Conversely, the vast majority of reports on infratentorial oligodendrogliomas antedate the era of diagnostic testing for LOH 1p19q or show no or non‐specific genetic alterations …”

Section: Introductionmentioning

confidence: 99%

“…1 Outside this typical location, any tumor morphologically reminiscent of oligodendroglioma will require particular consideration of tumor types able to histologically mimic oligodendroglioma by virtue of monotonous round nuclei and perivascular haloes. Intriguingly, reports of infratentorial oligodendrogliomas have remained rare [2][3][4][5][6][7][8][9][10][11][12][13] even though diagnosis of oligodendroglioma arguably has become increasingly more permissive over the past years. 14 To our knowledge, only two cases of cerebellar oligodendrogliomas with loss of heterozygosity (LOH) of 1p and 19q -the genetical hallmark of oligodendrogliomas -have recently been described in the literature, 15,16 while we are not aware of any report of genetically confirmed oligodendroglioma of the brain stem.…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, the vast majority of reports on infratentorial oligodendrogliomas antedate the era of diagnostic testing for LOH 1p19q or show no or non-specific genetic alterations. [2][3][4][5][6][7][8][9][10][11][12][13] The differential diagnosis of infratentorial oligodendroglioma includes in particular pilocytic astrocytoma, 17 clear cell ependymoma, 18,19 central or extraventricular neurocytoma, 20,21 clear cell meningioma, and glioneuronal tumors. Of the latter, rosette-forming glioneuronal tumor (RGNT) or cerebellar liponeurocytoma are not only prone to imitate oligodendroglioma, but have their sites of predilection in the infratentorial compartment.…”

Section: Introductionmentioning

confidence: 99%

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Anaplastic oligodendroglioma arising from the brain stem and featuring 1p/19q co‐deletion

et al. 2013

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With respect to localization, oligodendrogliomas are characterized by a marked preponderance of the cerebral hemispheres. Outside these typical sites, any tumor histopathologically reminiscent of oligodendroglioma a priori is likely to represent one of its morphological mimics, including clear cell ependymoma, neurocytoma, pilocytic astrocytoma or glioneuronal tumors. This is particularly relevant as several of the latter are in principle curable by surgery. Among extrahemispherical sites, bona fide oligodendroglioma - as characterized by loss of heterozygosity (LOH) of chromosome arms 1p and 19q - so far has not been documented to occur in the brain stem. Here, we report the case of a 55-year-old female patient with an anaplastic oligodendroglioma (WHO grade III) of the brain stem and cerebellum diagnosed by stereotactic biopsy and featuring combined LOH of 1p and 19q. A morphological peculiarity was a population of interspersed tumor giant cells, a phenomenon that has been referred to as polymorphous oligodendroglioma. Our findings confirm the notion that - although very infrequently - true oligodendrogliomas do occur in the infratentorial compartment.

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Tumors of the Central Nervous System in Children

Becker¹,

Jay²

1990

Management of Childhood Brain Tumors

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Oligodendroglioma of the Medulla Oblongata in a Neonate

Cited by 10 publications

References 20 publications

Oligodendroglioma and Its Variants: Radiologic-Pathologic Correlation

Oligodendroglioma and Its Variants: Radiologic-Pathologic Correlation

Anaplastic oligodendroglioma arising from the brain stem and featuring 1p/19q co‐deletion

Tumors of the Central Nervous System in Children

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