2011
DOI: 10.1039/c1sm05284e
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Oligonucleotide-functionalized hydrogels as stimuli responsive materials and biosensors

Abstract: Hydrogels are crosslinked hydrophilic polymers that undergo swelling in water. The gel volume is affected by many environmental parameters including temperature, pH, ionic strength, and solvent composition. Therefore, these factors have been traditionally used for making smart hydrogels. DNA, on the other hand, is a special block copolymer. Incorporation of DNA within a hydrogel network can have several important effects. For example, DNA can serve as a reversible crosslinker modulating the mechanical and rheo… Show more

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Cited by 179 publications
(137 citation statements)
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References 119 publications
(159 reference statements)
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“…To effectively protect these molecules and interface them with devices at the same time, much research effort has been devoted to developing materials for biosensor immobilization, including on gold, 2,3 silica, 4 carbon nanotubes, 5,6 graphene oxide, 7,8 lipid bilayers, 9 paper materials, 10 and hydrogels. 11,12 Hydrogels are particularly attractive for making optical sensors. [13][14][15][16][17][18][19] Biomolecular immobilization occurs not only on gel surface but also throughout the whole gel matrix, allowing for high loading capacity.…”
Section: Introductionmentioning
confidence: 99%
“…To effectively protect these molecules and interface them with devices at the same time, much research effort has been devoted to developing materials for biosensor immobilization, including on gold, 2,3 silica, 4 carbon nanotubes, 5,6 graphene oxide, 7,8 lipid bilayers, 9 paper materials, 10 and hydrogels. 11,12 Hydrogels are particularly attractive for making optical sensors. [13][14][15][16][17][18][19] Biomolecular immobilization occurs not only on gel surface but also throughout the whole gel matrix, allowing for high loading capacity.…”
Section: Introductionmentioning
confidence: 99%
“…An acrydite DNA has a similar reactivity as free acrylamide monomers, allowing a high incorporation efficiency [43]. While the field of DNA-functionalized hydrogels began in 1996 [44], most of the developments have occurred in the past ten years [45][46][47][48]. In this article, we only provide a concise review of recent developments in visual detection using DNA-functionalized hydrogels.…”
Section: Dna Attachmentmentioning
confidence: 99%
“…For easy handling and good template accessibility, MIP hydrogel nanoparticles (or nanogels) were prepared in this study. [24][25][26][27][28][29][30][31] …”
mentioning
confidence: 99%