Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide

Liu, Jiancheng; Sun, Hongxiang; Nie, Cunxi; Ge, Wenxia; Wang, Yongqiang; Zhang, Wenju

doi:10.1007/s10068-018-0414-1

Cited by 24 publications

(16 citation statements)

References 30 publications

(41 reference statements)

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“…Thymus and spleen functions can be evaluated by thymus index and spleen index [29]. The previous research indicated that polysaccharide can increase the thymus index and spleen index, and enhance the immune function of mice [30,31]. The results of this study showed that the thymus index and spleen index of mice increased after MHFP treatment, and the effect is a dosedependent manner.…”

Section: Discussionmentioning

confidence: 61%

Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice

Niu

Dong

Jiang

et al. 2020

Oxidative Medicine and Cellular Longevity

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The immunomodulatory effects of Malus halliana flower polysaccharide (MHFP) were investigated in this paper. The model of immunosuppressive mice was established by cyclophosphamide, which was treated with different dosages of MHFP (600, 400, and 200 mg/kg·d-1). The results showed that MHFP significantly increased the index of the spleen and thymus and improved the atrophy of immune organs. MHFP enhanced the ability of carbon clearance and phagocytosis of mononuclear phagocytes in mice. Meanwhile, MHFP promoted the proliferation of splenic lymphocytes. MHFP could enhance the content of serum hemolysin and improve the decrease of hemolysin induced by cyclophosphamide. The contents of ACP and LDH in the serum and spleen were determined, indicating that MHFP could enhance the activity of macrophages. MHFP promoted the content of cytokines (IL-2, IL-6, TNF-α, and IFN-γ) and mRNA expression. At the same time, the pathological changes of the spleen tissue also showed that MHFP could improve the immunosuppression induced by cyclophosphamide. In addition, MHFP increased the content of SOD, T-AOC, and CAT in the serum and spleen tissue, decreased the level of MDA, and improved the oxidative stress caused by cyclophosphamide. In conclusion, MHFP could effectively improve the immunosuppression and oxidative stress induced by cyclophosphamide and enhance the immune capacity of mice.

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Section: Discussionmentioning

confidence: 61%

Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice

Niu

Dong

Jiang

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Macrophages synthesize IL-1β in response to inflammatory signals, which further trigger the production of other inflammatory cytokines such as IL-6 in target cells. This synergistically promotes and amplifies the inflammatory response leading to tissue damage [49,50]. Thus, TNF-α, IL-1β, and IL-6 were used to evaluate the immunomodulatory and anti-inflammatory effects of the compound.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Activity of Low Molecular-Weight Peptides from Nibea japonica in RAW264.7 Cells via NF-κB Pathway

Zhang

Lin

et al. 2019

Marine Drugs

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In this study, a low molecular-weight (Mw) peptide named NJP (<1 kDa), was purified from a protein hydrolysate of Nibea japonica by ultrafiltration, and its immunomodulatory effect on RAW264.7 cells was evaluated. The lactate dehydrogenase (LDH) and MTT assays were performed to explore the cytotoxicity of NJP. The results showed that NJP promoted cell proliferation and had no significant toxic effects on RAW264.7 cells. Moreover, the cells formed multiple pseudopodia indicating that they were in activated state. Further tests showed that NJP significantly promoted phagocytic capacity, and the secretion of proinflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). It also increased the synthesis of nitric oxide (NO) by upregulating inducible nitric oxide synthase (iNOS) protein level. Flow cytometry revealed that NJP promoted cell cycle progression and increased the percentage of cells in G0/G1 phase. NJP promoted IκBα degradation, p65 and nuclear factor (NF)-κB activation and translocation by up-regulating IKKα/β protein expression. In conclusion, these results indicated that NJP exerts immunomodulatory effects on RAW264.7 cells through the NF-κB signaling pathway. Therefore, NJP can be incorporated in the production of functional foods or nutraceuticals.

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“…The potential elimination of ANFs by SSF is important for increasing the economic value and for making it possible for CAM to be well utilized as animal feed or food products in the food and feed industries. The beneficial effect of SSF in improving the nutritive value and bioactivity of various oilseed meals such as rapeseed meal [10], canola meal [13], soybean meal [14] and cottonseed meal [15] using different types of microorganisms have been previously reported. In an earlier study, CAM treated with Saccharomyces cerevisiae (yeast) was found to contain reduced phytic acid content compared to the unfermented control [16].…”

Section: Introductionmentioning

confidence: 96%

Physicochemical, Microbiological and Functional Properties of Camelina Meal Fermented in Solid-State Using Food Grade Aspergillus Fungi

Olukomaiya

Fernando

Mereddy³

et al. 2020

Fermentation

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Camelina meal (CAM) was fermented in solid-state using food grade Aspergillus fungi (A. sojae, A. ficuum and their co-cultures), and the physicochemical composition, microbiological and functional properties were investigated. SSF increased the starch contents but reduced (p < 0.05) the contents of soluble carbohydrate. The microbiological counts of the fermented meals were higher (p < 0.05) than that of the unfermented CAM. Phytic acid content reduced (p < 0.05) in the fermented meals. SSF reduced the protein molecular weight and colour attributes of CAM. The fermented camelina meals had increased (p < 0.05) bulk density and swelling capacity but reduced (p < 0.05) water absorption capacity. Thus, the study indicated that SSF with A. sojae, A. ficuum and their co-cultures influenced the physicochemical, microbiological and functional properties of CAM. There is potential for the development of value-added novel food and feed products from solid-state fermented camelina meal.

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Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide

Cited by 24 publications

References 30 publications

Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice

Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice

Immunomodulatory Activity of Low Molecular-Weight Peptides from Nibea japonica in RAW264.7 Cells via NF-κB Pathway

Physicochemical, Microbiological and Functional Properties of Camelina Meal Fermented in Solid-State Using Food Grade Aspergillus Fungi

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