Oligopeptide-side chained alginate nanocarrier for melittin-targeted chemotherapy

Wattanakul, Karnthidaporn; Imae, Toyoko; Chang, Wen‐Wei; Chu, Chih-Chien; Nakahata, Rina; Yusa, Shin‐ichi

doi:10.1038/s41428-019-0191-6

Cited by 11 publications

(6 citation statements)

References 26 publications

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“…Oligopeptide-Side Chained Alginate via the Amidation Method. A melittin-targeting drug carrier was successfully synthesized by the grafting of sodium alginate to an oligopeptide via an amidation method at different oligopeptide: alginate unit molar ratios [150]. e average sizes of the oligopeptide-alginate nanoparticles formed decreased with increasing oligopeptide contents, indicating intramolecular interactions between oligopeptide-side chains.…”

Section: Preparation Techniques For Production Ofmentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

142

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Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.

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Section: Preparation Techniques For Production Ofmentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

142

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“…The results of the cell viability assay revealed that 80% of Caco-2 cells (human colorectal adenocarcinoma) did not survive under the 2.5 μM dose of melittin-loaded oligopeptide-alginate NPs, while free melittin caused almost no damage to Caco-2 cells at the same molar concentration. However, only 0.4 μM of DOX caused 50% cell death, and the oligopeptide-alginate NPs did not enhance the performance of DOX ( Wattanakul et al, 2019 ). The involvement of alginate-based nanomaterials in preparing bee venom delivery systems has a great promise since it has been successfully used with other natural cytotoxic agents and venoms.…”

Section: Alginate-based Nanomaterials For Biomedical and Pharmaceutic...mentioning

confidence: 95%

“…Therefore, Rady et al (2017) suggested that the use of nanotechnology-mediated delivery of melittin could enhance the therapeutic efficacy of melittin in addition to providing a more effective route for the systemic delivery to target cancer cells with minimal or none hemolytic effect. In one of the studies reporting on the development of nanocarriers for melittin, researchers from Taiwan and Japan have successfully synthesized ionically cross-linked (by CaCl 2 ) oligopeptide-alginate NPs ( Wattanakul et al, 2019 ). They used commercially available melittin from Sigma-Aldrich, United States, and they compared it with DOX in terms of loading efficiency and cytotoxicity.…”

Section: Alginate-based Nanomaterials For Biomedical and Pharmaceutic...mentioning

confidence: 99%

Applications of Alginate-Based Nanomaterials in Enhancing the Therapeutic Effects of Bee Products

Al-Hatamleh

Alshaer

Hatmal

et al. 2022

Front. Mol. Biosci.

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Since the ancient times, bee products (i.e., honey, propolis, pollen, bee venom, bee bread, and royal jelly) have been considered as natural remedies with therapeutic effects against a number of diseases. The therapeutic pleiotropy of bee products is due to their diverse composition and chemical properties, which is independent on the bee species. This has encouraged researchers to extensively study the therapeutic potentials of these products, especially honey. On the other hand, amid the unprecedented growth in nanotechnology research and applications, nanomaterials with various characteristics have been utilized to improve the therapeutic efficiency of these products. Towards keeping the bee products as natural and non-toxic therapeutics, the green synthesis of nanocarriers loaded with these products or their extracts has received a special attention. Alginate is a naturally produced biopolymer derived from brown algae, the desirable properties of which include biodegradability, biocompatibility, non-toxicity and non-immunogenicity. This review presents an overview of alginates, including their properties, nanoformulations, and pharmaceutical applications, placing a particular emphasis on their applications for the enhancement of the therapeutic effects of bee products. Despite the paucity of studies on fabrication of alginate-based nanomaterials loaded with bee products or their extracts, recent advances in the area of utilizing alginate-based nanomaterials and other types of materials to enhance the therapeutic potentials of bee products are summarized in this work. As the most widespread and well-studied bee products, honey and propolis have garnered a special interest; combining them with alginate-based nanomaterials has led to promising findings, especially for wound healing and skin tissue engineering. Furthermore, future directions are proposed and discussed to encourage researchers to develop alginate-based stingless bee product nanomedicines, and to help in selecting suitable methods for devising nanoformulations based on multi-criteria decision making models. Also, the commercialization prospects of nanocomposites based on alginates and bee products are discussed. In conclusion, preserving original characteristics of the bee products is a critical challenge in developing nano-carrier systems. Alginate-based nanomaterials are well suited for this task because they can be fabricated without the use of harsh conditions, such as shear force and freeze-drying, which are often used for other nano-carriers. Further, conjunction of alginates with natural polymers such as honey does not only combine the medicinal properties of alginates and honey, but it could also enhance the mechanical properties and cell adhesion capacity of alginates.

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“…Meanwhile, the derivation of the side chain of oligopeptide-alginate NPs provided the basis for the specific binding of MEL, ultimately achieving potent killing ability on human cloned colon adenocarcinoma Caco-2 cells ( Wattanakul et al, 2019 ).…”

Section: Anticancer Effectsmentioning

confidence: 99%

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

Shi

Xie²,

Yang³

et al. 2022

Front. Pharmacol.

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Bee venom (BV), a type of defensive venom, has been confirmed to have favorable activities, such as anti-tumor, neuroprotective, anti-inflammatory, analgesic, anti-infectivity effects, etc. This study reviewed the recent progress on the pharmacological effects and mechanisms of BV and its main components against cancer, neurological disorders, inflammatory diseases, pain, microbial diseases, liver, kidney, lung and muscle injury, and other diseases in literature during the years 2018–2021. The related target proteins of BV and its main components against the diseases include Akt, mTOR, JNK, Wnt-5α, HIF-1α, NF-κB, JAK2, Nrf2, BDNF, Smad2/3, AMPK, and so on, which are referring to PI3K/Akt/mTOR, MAPK, Wnt/β-catenin, HIF-1α, NF-κB, JAK/STAT, Nrf2/HO-1, TrkB/CREB/BDNF, TGF-β/Smad2/3, and AMPK signaling pathways, etc. Further, with the reported targets, the potential effects and mechanisms on diseases were bioinformatically predicted via Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, disease ontology semantic and enrichment (DOSE) and protein-protein interaction (PPI) analyses. This review provides new insights into the therapeutic effects and mechanisms of BV and its main components on diseases.

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Oligopeptide-side chained alginate nanocarrier for melittin-targeted chemotherapy

Cited by 11 publications

References 26 publications

Current Status of Alginate in Drug Delivery

Current Status of Alginate in Drug Delivery

Applications of Alginate-Based Nanomaterials in Enhancing the Therapeutic Effects of Bee Products

Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

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