Oligosaccharide and short-chain fatty acid: A double-edged sword in obese mice by regulating food intake and fat synthesis

Chen, Kaiyang; Hu, Meimei; Tang, Ming; Gao, Congcong; Wang, Haikuan; Man, Shuli; Lu, Fuping

doi:10.1016/j.foodres.2022.111619

Cited by 17 publications

(8 citation statements)

References 39 publications

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“…Microbial production of SCFAs in the gut, notably butyric acid, is correlated to various health-promoting functions of dietary fiber intake, e.g. , anti-inflammatory, antiobesity and antidiabetic effect. − Therefore, together with the modulation of the microbial community, the SCFA data obtained may suggest that soluble FGAX samples have potential as prebiotics. For the sake of completion, it should be added that the microbiota did not liberate any significant amounts of branched SCFA, i.e.…”

Section: Resultsmentioning

confidence: 99%

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Lin

Holck

et al. 2023

J. Agric. Food Chem.

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Corn bran is exceptionally rich in substituted glucuronoarabinoxylan polysaccharides, which are monoferuloylated and cross-linked by diferulic acid moieties. Here, we assessed the potential prebiotic activity of three enzymatically solubilized corn bran glucuronoarabinoxylans: medium feruloylated (FGAX-M), laccase cross-linked FGAX-M (FGAX-H), and alkali-treated FGAX-M devoid of feruloyl substitutions (FGAX-B). We examined the influence of these soluble FGAX samples on the gut microbiome composition and functionality during in vitro simulated colon fermentations, determined by 16S rRNA gene amplicon sequencing and assessment of short-chain fatty acid (SCFAs) production. All FGAX samples induced changes in the relative composition of the microbiota and the SCFA levels after 24 h of in vitro fermentation. The changes induced by FGAX-M and FGAX-H tended to be more profound and more similar to the changes induced by inulin than changes conferred by FGAX-B. The microbiota changes induced by FGAX-M and FGAX-H correlated with an increase in the relative abundance of Anaerostipes and with increased butyric acid production, while the changes induced by the FGAX-B sample were less compelling. The results imply that solubilized, substituted diferuloylated corn bran glucuronoarabinoxylans may be potential prebiotic candidates and that both single feruloylations and diferuloyl cross-links influence the prebiotic potential of these arabinoxylan compounds.

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Section: Resultsmentioning

confidence: 99%

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Lin

Holck

et al. 2023

J. Agric. Food Chem.

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“…29,30 Because of their chemical structures, they cannot be digested in the small intestine; instead, they are anaerobically fermented by bacteria in the hindgut. 31 This indigestible dietary fiber/carbohydrate fermentation process produces SCFAs (e.g., acetate and butyrate), which have significant positive impacts on intestinal epithelial cell function, 32,33 including the maintenance of metabolism, proliferation, and differentiation; they also promote a low pH in the intestinal environment, which supports beneficial microorganisms and reduces the viability of pathogenic bacteria. 33 The beneficial effects of AgaroS supplementation include anti-diabetic and anti-obesity activities, 32 as well as potential prebiotic activity.…”

Section: Discussionmentioning

confidence: 99%

“…31 This indigestible dietary fiber/carbohydrate fermentation process produces SCFAs (e.g., acetate and butyrate), which have significant positive impacts on intestinal epithelial cell function, 32,33 including the maintenance of metabolism, proliferation, and differentiation; they also promote a low pH in the intestinal environment, which supports beneficial microorganisms and reduces the viability of pathogenic bacteria. 33 The beneficial effects of AgaroS supplementation include anti-diabetic and anti-obesity activities, 32 as well as potential prebiotic activity. 34 Moreover, there is increasing evidence that AgaroS have ben-eficial effects on intestinal inflammation 23 and antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Agaro-oligosaccharides mitigate deoxynivalenol-induced intestinal inflammation by regulating gut microbiota and enhancing intestinal barrier function in mice

Wang,

Wang

et al. 2024

Food Funct.

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“…SCFAs can further influence the absorption of fat and cholesterol by modulating bile acid levels [78] , maintaining the balance of the gut microbiota, and positively affecting digestion and nutrient absorption, thereby reducing feed intake and improving feed utilization efficiency [79] . Additionally, acetic acid and butyric acid have been shown to inhibit animal feed intake and reduce fat deposition [80,81] .…”

Section: Discussionmentioning

confidence: 99%

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

Gao,

Zheng,

Mao

et al. 2024

Preprint

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The RFI is independent of growth traits and selecting individuals with low RFI can improve feed efficiency without affecting the laying performance and egg quality of hens. In this study it was found that under similar egg production rates hens in the HRFI group had lower nutrient digestion capacity disrupted lipid metabolism and lower feed utilization efficiency than those in the LRFI group. Further research and validation are needed to investigate the effects of AST HDL-C and ACTH on feed efficiency in the late laying period through serum biochemical index analysis. Through multiomics analysis genes such as ADCY2 ADCY8 CCKAR ACSS2 FABP1 and FABP4 and metabolites such as LysoPI(18:2(9Z,12Z)/0:0) were identified as key genes and biomarkers related to RFI in laying hens during the late laying period. These findings are important for developing strategies to improve feed efficiency in Rhode Island Red pure-line chickens during the late laying period. Additionally in-depth investigations such as histological observations enzyme activity analysis and integration of multiomics techniques are needed to unravel the physiological and biochemical mechanisms of digestive organs that impact feed utilization efficiency in poultry.

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Oligosaccharide and short-chain fatty acid: A double-edged sword in obese mice by regulating food intake and fat synthesis

Cited by 17 publications

References 39 publications

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Soluble, Diferuloylated Corn Bran Glucuronoarabinoxylans Modulate the Human Gut Microbiota In Vitro

Agaro-oligosaccharides mitigate deoxynivalenol-induced intestinal inflammation by regulating gut microbiota and enhancing intestinal barrier function in mice

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

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