Olive Leaves (<i>Olea europaea</i> L) Extract Loaded Lipid Nanoparticles: Optimization of Processing Parameters by Box-Behnken Statistical Design, <i>in-vitro</i> Characterization, and Evaluation of Anti-oxidant and Anti-microbial Activity

Abstract

IntroductionThe Dicotyledons Oleaceae family consists of about 30 genera of deciduous plants including olive trees and it has related around 600 species. Oleaceae members are well grown in topical and sub-temperate reasons of Asia 1) . Olive tree (Olea europaea) oil obtained from different parts like fruit, leaves, etc. has many health benefits upon regular consumption. Traditionally it was used as a folk medicine for remedying various types of fevers and other problems associated with body 2) .Olive leaves extract exhibited several therapeutics activities like anti-hypertensive, hypoglycemic, antimicrobial, hypouricemic, etc