Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: <i>in vitro</i> and <i>ex vivo</i> evaluation

Gul, Uzma; Khan, Muhammad Imran; Madni, Asadullah; Sohail, Muhammad; Rehman, Mubashar; Rasul, Akhtar; Peltonen, Leena

doi:10.1080/10717544.2022.2039805

Cited by 35 publications

(18 citation statements)

References 38 publications

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“…Lower PDI values corresponds to narrower size distributions in the dispersed samples. It was generally considered that NE were fairly homogeneous at the PDI values below 0.35 (Gul et al., 2022 ). The PDI below 0.7 proves that the distribution was acceptable.…”

Section: Resultsmentioning

confidence: 99%

Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization

Zhang¹,

Yang

Luo

et al. 2022

Drug Delivery

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Isoliquiritigenin (ISL), as a natural flavonoid, has been proven to have therapeutic potential for corneal neovascularization (CNV) treatment; however, its therapeutic use is restricted due to its poor aqueous solubility and limited bioavailability. To overcome these limitations, a novel ISL-loaded nanoemulsion (ISL-NE) was designed for inhibiting CNV in this study. ISL-NE formulation was composed of propylene glycol dicaprylate (PGD), Cremophor® EL (EL35), polyethylene glycol 400 (PEG 400) and adding water with sodium hyaluronate, its particle size was 34.56 ± 0.80 nm with a low polydispersity index of less than 0.05, which suggested a narrow size distribution. The results demonstrated that ISL-NE released higher and permeated more drug than ISL suspension (ISL-Susp) in in vitro drug release and ex vivo corneal permeation study. ISL-NE showed no cytotoxicity in human corneal epithelial cells toxicity study, which was consistent with the result of ocular irritation study in rabbit eyes. ISL-NE had bioavailability 5.76-fold, 7.80-fold and 2.13-fold higher than ISL-Sups in tears, cornea and aqueous humor after a single dose of ISL-NE, respectively. Furthermore, the efficacy of ISL-NE treatment (0.2% ISL) was comparable to that of dexamethasone treatment (0.025%) in the inhibition of CNV in mice model. Enzyme-linked immunosorbent assay (ELISA) showed that the expressions of corneal vascular endothelial growth factor (VEGF-A) and matrix metalloproteinase (MMP-2) were decreased. In conclusion, the ISL-NE demonstrated excellent physicochemical properties, good tolerance, and enhanced ocular bioavailability. It could be a promising, safe, and effective treatment for CNV.

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Section: Resultsmentioning

confidence: 99%

Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization

Zhang¹,

Yang

Luo

et al. 2022

Drug Delivery

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“…Hence, the aqueous phase was added with continuous vortexing for one minute [ 34 ]. Afterwards, the uniform dispersion system obtained was ultrasonicated using an ultrasonic homogenizer (FS-300N, Gaoyou city, China) in a water bath for a varying time duration (five minutes) at a constant amplitude of 50% [ 16 , 18 ]. The impact of the composition variables on the droplet size and PDI of the developed TAM-NE system was evaluated, as shown in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, forming a NEG system is an ideal solution for this matter. The three optimised RAM-NEG formulations were then dispersed in Carbopol ® 940 (0.5% w / w ) gel to form TAM-NEG [ 16 , 17 ]. Glycerin was also used as a humectant for the dispersion system, which helps to provide a smooth and soothing effect (5% w / w ).…”

Section: Methodsmentioning

confidence: 99%

“…Unlike typical dispersion preparations, which are tenfold larger when measured in micrometers, NE carriers were reported to increase bioavailability and enhance the efficacy of several pharmaceuticals as inflammatory inhibitors [ 12 ], including propranolol [ 13 ], econazole nitrate [ 14 ], lapachol [ 15 ], terbinafine hydrochloride, [ 16 ] and Ibuprofen [ 17 ]. Furthermore, the conversion of NE formulations into a nanoemulgel (NEG) preparation is a favourable approach that can enhance the pharmaceutical properties of the final product, such as its spreadability and stability.…”

Section: Introductionmentioning

confidence: 99%

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Tamoxifen Citrate Containing Topical Nanoemulgel Prepared by Ultrasonication Technique: Formulation Design and In Vitro Evaluation

Alyami

Alshehri

et al. 2022

Gels

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The present study aims to design and develop a nanoemulgel formulation of Tamoxifen citrate (TAM), a water-insoluble, potent anticancer drug, using the spontaneous emulsification method to improve topical delivery, achieve high accumulation at the tumour site, and spare the healthy tissues. The oil-based selection was related to the TAM solubility, while the surfactant and co-surfactant were chosen based on the droplets’ thermodynamic stability and size. Afterwards, a pseudo-ternary phase diagram was built for the most promising formulation using two oils, olive and sesame, with a varied mix of Tween 40 as the surfactant and Trascutol HP as the co-surfactant (Smix), by the optimisation of experiments. The nanoemulsion (NE) formulations that were prepared were found to have an average droplet size of 41.77 ± 1.23 nm and 188.37 ± 3.53 nm, with suitable thermodynamic stability and physicochemical properties. Both olive and sesame oils are natural food additives due to their associated antioxidant effects; therefore, they showed no toxicity profile on breast cell lines (MCF-7, ATCC number HTB-22). The TAM-NE preparations revealed a prolonged and doublings superior cumulative percentage of in vitro release of TAM compared to TAM plain gel suspension over 24 h. The release data suggested that the Higuchi model was the best fitting kinetical model for the developed formulations of NE1, NE9, and NE18. The extended release of the drug as well as an acceptable amount of the drug permeated TAM via nanogel preparations suggested that nanoemulgel (NEG) is suitable for the topical delivery of TAM in breast cancer management. Thus, this work suggests that a nanogel of TAM can improve anticancer properties and reduce systemic adverse effects compared to a suspension preparation of TAM when applied in the treatment of breast cancer.

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“…Sesame oil is considered one of the most important sources of β-sitosterol which is one of the most powerful natural anti-inflammatory [ 7 , 40 ] which used to prevent and treat tissue necrosis [ 40 ]. Additionally, olive oil contains several bioactive ingredients which enhance the regeneration of necrosed tissues [ 8 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Recently, a mixture of rosemary and chamomile oils with honey, induced efficient and rapid skin regeneration of equine-skin wounds experimentally and clinically [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Anis

Sharshar

Hanbally

et al. 2022

JCM

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Skin burns are one of the most difficult medical problems. Recently, studies have been directed towards development of natural products in order to identify effective and safe remedies. In the present study, we evaluated the efficacy of a natural composite (formulated from honey and essential oils) compared with MEBO® (0.25% β-sitosterol) and DERMAZIN® creams (1% silver-sulfadiazine) in the treatment of thermally induced skin burns. For this purpose, four burn-wounds were created on the back of male New Zealand rabbits (n = 10) using a thermal stamp under the effect of general anesthesia. Each wound represents one of the following groups: non-treated, natural composite-cream, MEBO®-cream, and silver-sulfadiazine treated groups, respectively. Treatments were applied once a day topically until one of these wounds appeared to be healed grossly. The non-treated group received no treatment. Grossly, skin burns have been healed after 28 days of the treatment in all groups except of the non-treated group. The healing efficacy of the natural composite, MEBO® and silver-sulfadiazine creams was quite similar macroscopically. However, microscopically, the epidermal layer of the composite-cream treated group was more mature than those of both MEBO® and silver-sulfadiazine creams treated groups. In conclusion, the tested composite may be a promising effective and inexpensive treatment of skin burns.

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Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation

Cited by 35 publications

References 38 publications

Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization

Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization

Tamoxifen Citrate Containing Topical Nanoemulgel Prepared by Ultrasonication Technique: Formulation Design and In Vitro Evaluation

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

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