Olive oil limited motor disruption and neuronal damage in parkinsonism induced by MPTP administration

Farfán‐García, Eunice D.; Abad-García, Antonio; Alatorre, Alberto; Pérez-Capistran, Teresa; Querejeta, Enrique; Soriano-Ursúa, Marvin A.

doi:10.1177/2397847320922939

Cited by 7 publications

(3 citation statements)

References 61 publications

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“…The protective effect of EVOO against neurodegeneration using the MPTP‐induced murine model of acute PD was investigated using the open field, rotarod, and grasp strength tests as well as immunohistochemistry analysis. EVOO reduced MPTP‐induced neurotoxicity evidenced by the performance in the behavioral motor tests and the number of total neurons in SN (Farfán‐García et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Iranshahy

Javadi

Sahebkar

2022

Phytotherapy Research

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In Persian Medicine (PM), PD (brain‐based tremor) is a known CNS disorder with several therapeutic and preventive options. In their medical textbooks and pharmacopeias, Persian great scientists such as Rhazes (854–925 AD), Avicenna (980–1037 AD), and Jorjani (1042–1136 AD), have discussed pharmacological and nutritional strategies for the prevention, slowing progression, and treatment of PD. In the present study, we surveyed plant‐ and animal‐based foods recommended by PM for the prevention and treatment of CNS‐related tremors. In vivo and in‐vitro pharmacological evidence supporting the beneficial effects of PM‐recommended foods in prevention and alleviating PD, major active phytochemicals along with the relevant mechanisms of action were studied. Several PM plants possess potent antioxidant, antiinflammatory, and PD preventing properties. Garlic and allicin, cabbage and isothiocyanates, chickpea seed and its O‐methylated isoflavones biochanin A and formononetin, cinnamon, and cinnamaldehyde, saffron and its crocin, crocetin, and safranal, black cumin and its thymoquinone, black pepper and piperine, pistachio and genistein and daidzein, and resveratrol are among the most effective dietary itemsagainst PD. They act through attenuating neurotoxin‐induced memory loss and behavioral impairment, oxidative stress, and dopaminergic cell death. PM‐recommended foods can help alleviate PD progression and also discovering and developing new neuroprotective anti‐PD pharmaceuticals.

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Section: Resultsmentioning

confidence: 99%

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Iranshahy

Javadi

Sahebkar

2022

Phytotherapy Research

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“…Olive oil administration has been found to reduce the number of apoptotic and necrotic cells in the hippocampus [25]. However, olive oil administration significantly increases neuronal survival in the brain in the Parkinsonism model created in C57BL/6 mice [26]. In addition to the direct protective effect of propolis, olive oil can protect by suppressing the pathways that trigger cell death in the brain tissue with the bioactive molecules it contains.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Propylene Glycol Extract of Propolis on Central Nervous System and Liver in Pregnant and Neonatal Rats

Silici

Okan

Köklü

et al. 2023

Z Geburtshilfe Neonatol

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Background Propolis has become one of the most preferred supplements due to its beneficial biological properties. Organic (water and vegetable oils) and chemical (ethyl alcohol, propylene glycol, and glycerol) solvents are used for propolis extraction. However, the effects of these chemicals on health should be taken into account. Objectives In this study, the effects of propolis extracts on health were evaluated. Methods 32 pregnant Wistar albino rats and 64 neonatal/young adults were given three different extractions of propolis (propylene glycol, water, and olive oil). Histopathological analyses were performed on the liver and brain, and blood samples were taken from the hearts of rats. Results Histopathological scoring showed that the intensity of pycnotic hepatocyte, sinusoidal dilatation, and bleeding was high in liver samples of pregnant and baby rats given propylene glycol extract of propolis (p<0.05). Propylene glycol extract caused dilatation of blood vessels and apoptosis of neurons in brain tissue. The histopathological score was significantly lower in liver and brain tissues of rats treated with water and olive oil extract compared to propylene propolis groups (p<0.05). Liver enzyme levels in the blood increased in propylene propolis rats (p<0.05). Conclusion Histopathological changes and biochemical alterations may indicate that propylene glycol extracts of propolis are more toxic than olive oil and water extracts. Therefore, olive oil and water extracts of propolis are more reliable than propylene glycol extract in pregnant and infant rats.

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“…The acute MPTP/p protocol is similar to that described previously [29][30][31]. Briefly, probenecid (250 mg/kg; Sigma-Aldrich, St. Louis, MO, USA) was injected 30 min before the first MPTP injection.…”

Section: Mptp Treatmentmentioning

confidence: 99%

Behavioral characterization in MPTP/p mouse model of Parkinson’s disease

Wada¹,

Ang²,

Weerasinghe-Mudiyanselage³

et al. 2021

J. Integr. Neurosci.

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We evaluated the practicability of using the rarely utilized C57BL/6N mouse as a Parkinson's disease model established via the acute MPTP/probenecid (MPTP/p) protocol. We confirmed dopaminergic degeneration in terms of decreased expression levels of tyrosine hydroxylase in the substantia nigra and striatum of MPTP/plesioned mice. In addition, acute MPTP/p-lesioned mice demonstrated initial motor dysfunctions followed by spontaneous recovery. Interestingly, these MPTP/p-lesioned mice exhibited anxiolytic and antidepressive behaviors upon recovery from these motor deficits. Additionally, increased expression of norepinephrine transporters in several brain regions, including the hippocampus, medial prefrontal cortex, and striatum, and an elevated rate of adult neurogenesis (in terms of increased numbers of doublecortin-positive neuroblasts) in the hippocampus were observed a ter recovery from motor dysfunctions. We suggest that the emotional alterations observed under these experimental conditions may be associated with enhanced adult neurogenesis, increased levels of norepinephrine transporters, and/or a possible interplay between these two factors. Consequently, this acute MPTP/p model adequately satisfies the criteria for the validity of a Parkinson's disease model regarding dopaminergic loss and motor impairment. However, the non-motor findings may o fer novel evidence against the practicability of utilizing the acute MPTP/p-lesioned mice for modeling the emotional aberrations found in Parkinson's disease patients.

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Olive oil limited motor disruption and neuronal damage in parkinsonism induced by MPTP administration

Cited by 7 publications

References 61 publications

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Toxicity of Propylene Glycol Extract of Propolis on Central Nervous System and Liver in Pregnant and Neonatal Rats

Behavioral characterization in MPTP/p mouse model of Parkinson’s disease

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